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DUB-DECODE SIGNED

Systematic Decoding of Deubiquitylase-Regulated Signaling Networks

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

DUB-DECODE project word cloud

Explore the words cloud of the DUB-DECODE project. It provides you a very rough idea of what is the project "DUB-DECODE" about.

systematic avenues stability molecular diverse ubiquitylation regulate integrate unbiased virtually generation innovative biology mass largely cellular human technologies proteomic conserved proteins versatile dysregulated posttranslational functions sophisticated central governed regulatory physiology small vital eukaryote almost despite cells covalently conjugated comprehensively modification expression models mutation dubs systematically protein substrate frequently biological deubiquitylases acts regulates cell signaling gap remove networks ptm regulated decode exclusive modern dependent reversible function thereby proteases allowed spectrometry ubiquitin modifiers proteomics little diseases mammalian site dub mechanisms forms interdisciplinary sites hampering quantification evolutionarily

Project "DUB-DECODE" data sheet

The following table provides information about the project.

Coordinator	KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Total cost	1˙972˙570 €
EC max contribution	1˙972˙570 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2015
Duration (year-month-day)	from 2015-10-01 to 2020-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	coordinator	1˙972˙570.00

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Project objective

Cellular processes are largely governed by sophisticated protein posttranslational modification (PTM)-dependent signaling networks, and a systematic understanding of regulatory PTM-based networks is a key goal in modern biology. Ubiquitin is a small, evolutionarily conserved signaling protein that acts as a PTM after being covalently conjugated to other proteins. Reversible ubiquitylation forms the most versatile and largest eukaryote-exclusive signaling system, and regulates the stability and function of almost all proteins in cells. Deubiquitylases (DUBs) are ubiquitin-specific proteases that remove substrate-conjugated ubiquitin, and thereby regulate virtually all ubiquitylation-dependent signaling. Because of their central role in ubiquitin signaling, DUBs have essential functions in mammalian physiology and development, and the dysregulated expression and mutation of DUBs is frequently associated with human diseases. Despite their vital functions, very little is known about the proteins and ubiquitylation sites that are regulated by DUBs and this knowledge gap is hampering our understanding of the molecular mechanisms by which DUBs control diverse biological processes. Recently, we developed a mass spectrometry-based proteomics approach that allowed unbiased and site-specific quantification of ubiquitylation on a systems-wide scale. Here we propose to comprehensively investigate DUB-regulated ubiquitin signaling in human cells. We will integrate interdisciplinary approaches to develop next-generation cell models and innovative proteomic technologies to systematically decode DUB function in human cells. This will enable a novel and detailed understanding of DUB-regulated signaling networks, and open up new avenues for further research into the mechanisms and biological functions of ubiquitylation and of ubiquitin-like modifiers.

Publications

List of publications.
year	authors and title	journal	last update
2016	Sebastian A Wagner, Shankha Satpathy, Petra Beli, Chunaram Choudhary SPATA2 links CYLD to the TNFâ€Î± receptor signaling complex and modulates the receptor signaling outcomes published pages: 1868-1884, ISSN: 0261-4189, DOI: 10.15252/embj.201694300	The EMBO Journal 35/17	2019-06-06
2018	Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity published pages: 972-988.e23, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.03.050	Cell 173/4	2019-06-06
2018	Thomas Wild, Magda Budzowska, Susanne Hellmuth, Susana Eibes, Gopal Karemore, Marin Barisic, Olaf Stemmann, Chunaram Choudhary Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint published pages: 2317-2328.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.10.104	Cell Reports 25/9	2019-02-25

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