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Principles of Polarity – Integrating genetic, biophysical and computational approaches to understand cell and tissue polarity

Total Cost €


EC-Contrib. €






 PolarNet project word cloud

Explore the words cloud of the PolarNet project. It provides you a very rough idea of what is the project "PolarNet" about.

integrative    genetics    disease    polarity    insights    intersectoral    fact    complementary    description    organismal    stem    organisms    career    private    underlying    brings    successful    fungi    employ    interactions    base    multicellular    polarnet    industry    quantitative    mechanical    starting    combination    countries    establishment    academic    medically    biological    molecular    underlies    generation    forefront    imaging    train    external    biomedical    basic    tissues    strengthen    experimental    broad    resolution    maintenance    translation    organism    cultured    players    progress    opportunity    motility    training    technological    functions    biophysics    provides    protein    principles    scientists    underscored    perturbed    multidisciplinary    image    mammalian    biochemistry    performed    ranging    tight    cells    stage    cancer    setting    expanding    combine    polarize    animal    excellent    live    biochemical    cell    model    point    biology    theoretical   

Project "PolarNet" data sheet

The following table provides information about the project.


Organization address
postcode: 3584 CS

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 3˙935˙968 €
 EC max contribution 3˙935˙968 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2019-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT NL (UTRECHT) coordinator 1˙276˙871.00
2    CARDIFF UNIVERSITY UK (CARDIFF) participant 546˙575.00
3    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 525˙751.00
5    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 273˙287.00
6    UNIVERSITAT BASEL CH (BASEL) participant 265˙226.00
8    INSTITUT CURIE FR (PARIS) participant 262˙875.00
10    ELEVATE BV NL (UTRECHT) partner 0.00
11    NDS Ltd. UK (Cardiff) partner 0.00
12    Scientific Volume Imaging BV NL (Hilversum) partner 0.00
13    Union Biometrica BVBA BE (Geel) partner 0.00


 Project objective

The ability of cells to polarize underlies the most basic biological functions such as motility and response to external challenges, but also the formation and maintenance of tissues in a multicellular organism. The importance of cell polarity is underscored by the fact that cell polarity is essential for animal development and is perturbed in disease states such as cancer. Understanding cell polarity requires knowledge of the molecular players involved and a quantitative description of their biochemical interactions, as well as the mechanical processes underlying polarity establishment. PolarNet brings together academic and private partners from 7 European countries to establish a multidisciplinary, intersectoral training and research programme that will study the basic principles of cell polarity. The research will combine complementary model systems ranging from fungi and cultured mammalian cells to whole organisms, and employ a broad set of approaches such as advanced genetics, protein biochemistry, high-resolution live imaging and image analysis, biophysics and theoretical modelling. This setting provides an opportunity to train early stage researchers in a unique combination of experimental and theoretical approaches. This will provide an excellent starting point for a successful career in the rapidly expanding field of multidisciplinary or ‘integrative’ biology. Training Europe’s next generation of scientists at the forefront of cell and organismal polarity research is crucial for progress in several medically important fields, including cancer research and stem cell biology. The tight collaboration with non-academic partners will strengthen the technological base of different projects and provide early stage researchers with insights into the translation potential of the performed studies and the career development opportunities in biomedical industry.


List of deliverables.
Analysis of Axin1, Axin2, and APC roles in liver and intestinal cell division Documents, reports 2020-03-11 13:02:59
Mechanisms of mechanotransduction during division in epithelial tissue Documents, reports 2020-03-11 13:03:37
Mechanistic role of microtubules in polarization of 3D-cultured epithelial cells Documents, reports 2020-03-11 13:02:58
Mechanochemical model of PAR polarity patterning Documents, reports 2020-03-11 13:02:59
Analysis of the mechanisms that maintain tissue integrity in seam epithelium Documents, reports 2020-03-11 13:03:01
Biochemical characterization of the Scrib polarity complex Documents, reports 2020-03-11 13:03:28
GTPase-regulator circuits essential for yeast and C. elegans polarity Documents, reports 2020-03-11 13:03:31
Computational model of epithelial regeneration after wounding Documents, reports 2020-03-11 13:01:44
Analysis of cell contact dependent transmission of Wnt-signal in seam cell PCP Documents, reports 2020-03-11 13:01:49
Review article by the ESRs incorporating data obtained by PolarNet Documents, reports 2020-03-11 13:02:59
Summaries of ESRs results placed on website by the ESRs Websites, patent fillings, videos etc. 2020-03-11 13:03:00
Comprehensive, quantitative mathematical description of PAR polarity Documents, reports 2020-03-11 13:03:36
Characterization of PAR, Crumbs and Scribble in C. elegans larval epithelia Documents, reports 2020-03-11 13:03:32
Semi-automated culturing of organoids in a bioreactor Documents, reports 2020-03-11 13:02:58
Video highlighting importance of polarity for website & youtube Websites, patent fillings, videos etc. 2020-03-11 13:03:02
Super-resolution localization of polarity regulators at the plasma membrane Documents, reports 2020-03-11 13:03:32
Symposium 2 Other 2020-03-11 13:03:01
Quantitative analyses of local polarity perturbations on polarized growth Documents, reports 2020-03-11 13:03:30
Role of phosphoinositides in control of cell polarity during collective migration Documents, reports 2020-03-11 13:03:29
Bi-weekly ‘Polarizing Cells’ blog entry on website Websites, patent fillings, videos etc. 2020-03-11 13:03:02
Symposium 3 Other 2020-03-11 13:03:02
ESRs evaluated for Doctorate degree application Other 2020-03-11 13:03:31
Draft Periodic Report Documents, reports 2019-06-19 17:44:45
Symposium 1 Other 2019-06-19 17:44:45
Midterm review Meeting Other 2019-06-19 17:44:45
Summer School Other 2019-06-19 17:44:45
Progress Report Documents, reports 2019-06-19 17:44:45
Web presence Websites, patent fillings, videos etc. 2019-06-19 17:44:45

Take a look to the deliverables list in detail:  detailed list of PolarNet deliverables.


year authors and title journal last update
List of publications.
2019 Bertille Bance, Shailaja Seetharaman, Cécile Leduc, Batiste Boëda, Sandrine Etienne-Manneville
Microtubule acetylation but not detyrosination promotes focal adhesion dynamics and astrocyte migration
published pages: jcs225805, ISSN: 0021-9533, DOI: 10.1242/jcs.225805
Journal of Cell Science 132/7 2019-11-28
2019 Eric C. Arakel, Martina Huranova, Alejandro F. Estrada, E-Ming Rau, Anne Spang, Blanche Schwappach
Dissection of GTPase-activating proteins reveals functional asymmetry in the COPI coat of budding yeast
published pages: jcs232124, ISSN: 0021-9533, DOI: 10.1242/jcs.232124
Journal of Cell Science 132/16 2019-11-28
2020 Eric Victor van Leen, Florencia di Pietro, Yohanns Bellaïche
Oriented cell divisions in epithelia: from force generation to force anisotropy by tension, shape and vertices
published pages: 9-16, ISSN: 0955-0674, DOI: 10.1016/
Current Opinion in Cell Biology 62 2019-11-28
2018 Shailaja Seetharaman, Sandrine Etienne-Manneville
Integrin diversity brings specificity in mechanotransduction
published pages: 49-64, ISSN: 0248-4900, DOI: 10.1111/boc.201700060
Biology of the Cell 110/3 2019-11-28
2018 Sonja Hinz, Gemma Navarro, Dasiel Borroto-Escuela, Benjamin F. Seibt, York-Christoph Ammon, Elisabetta de Filippo, Azeem Danish, Svenja K. Lacher, Barbora Červinková, Muhammad Rafehi, Kjell Fuxe, Anke C. Schiedel, Rafael Franco, Christa E. Müller
Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.24423
Oncotarget 9/17 2019-11-28
2019 Nathan Jespersen, Aidan Estelle, Nathan Waugh, Norman E Davey, Cecilia Blikstad, York-Christoph Ammon, Anna Akhmanova, Ylva Ivarsson, David A Hendrix, Elisar Barbar
Systematic identification of recognition motifs for the hub protein LC8
published pages: e201900366, ISSN: 2575-1077, DOI: 10.26508/lsa.201900366
Life Science Alliance 2/4 2019-11-28
2018 Chiara De Pascalis, Carlos Pérez-González, Shailaja Seetharaman, Batiste Boëda, Benoit Vianay, Mithila Burute, Cécile Leduc, Nicolas Borghi, Xavier Trepat, Sandrine Etienne-Manneville
Intermediate filaments control collective migration by restricting traction forces and sustaining cell–cell contacts
published pages: 3031-3044, ISSN: 0021-9525, DOI: 10.1083/jcb.201801162
The Journal of Cell Biology 217/9 2019-11-28
2019 Patrícia M. Silva, Charles Puerner, Agnese Seminara, Martine Bassilana, Robert A. Arkowitz
Secretory Vesicle Clustering in Fungal Filamentous Cells Does Not Require Directional Growth
published pages: 2231-2245.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.07.062
Cell Reports 28/8 2019-11-28
2020 Amalia Riga, Victoria G Castiglioni, Mike Boxem
New insights into apical-basal polarization in epithelia
published pages: 1-8, ISSN: 0955-0674, DOI: 10.1016/
Current Opinion in Cell Biology 62 2019-11-28
2020 Eider Valle-Encinas, Trevor C. Dale
Wnt ligand and receptor patterning in the liver
published pages: 17-25, ISSN: 0955-0674, DOI: 10.1016/
Current Opinion in Cell Biology 62 2019-11-28
2019 Jacob D. Reich, Lars Hubatsch, Rukshala Illukkumbura, Florent Peglion, Tom Bland, Nisha Hirani, Nathan W. Goehring
Regulated Activation of the PAR Polarity Network Ensures a Timely and Specific Response to Spatial Cues
published pages: 1911-1923.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2019.04.058
Current Biology 29/12 2019-11-28
2019 Shailaja Seetharaman, Sandrine Etienne-Manneville
Microtubules at focal adhesions – a double-edged sword
published pages: jcs232843, ISSN: 0021-9533, DOI: 10.1242/jcs.232843
Journal of Cell Science 132/19 2019-11-28
2019 Miao Yu, Shimin Le, York-Christoph Ammon, Benjamin T. Goult, Anna Akhmanova, Jie Yan
Force-Dependent Regulation of Talin–KANK1 Complex at Focal Adhesions
published pages: 5982-5990, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.9b01732
Nano Letters 19/9 2019-11-28

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