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GLYCOVAX SIGNED

A training network for the rational design of the next generation of well-defined glycoconjugate vaccines

Total Cost €

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EC-Contrib. €

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Partnership

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 GLYCOVAX project word cloud

Explore the words cloud of the GLYCOVAX project. It provides you a very rough idea of what is the project "GLYCOVAX" about.

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Project "GLYCOVAX" data sheet

The following table provides information about the project.

Coordinator
GLAXOSMITHKLINE VACCINES SRL 

Organization address
address: VIA FIORENTINA 1
city: SIENA
postcode: 53100
website: www.novartis.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.glycovax.eu
 Total cost 3˙554˙499 €
 EC max contribution 3˙554˙499 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2019-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GLAXOSMITHKLINE VACCINES SRL IT (SIENA) coordinator 516˙122.00
2    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) participant 716˙837.00
3    UNIVERSITEIT LEIDEN NL (LEIDEN) participant 510˙748.00
4    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 280˙879.00
5    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 262˙875.00
6    GLYCOUNIVERSE GMBH & CO. KOMMANDITGESELLSCHAFT AUF AKTIEN DE (POTSDAM) participant 249˙216.00
7    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 249˙216.00
8    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS ES (DERIO VIZCAYA) participant 247˙872.00
9    SVEUCILISTE U RIJECI, MEDICINSKI FAKULTET HR (RIJEKA) participant 247˙761.00
10    INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES PT (LISBOA) participant 238˙356.00
11    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 34˙613.00
12    ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU IT (SIENA) partner 0.00

Map

 Project objective

GLYCOVAX is a network for the education of promising young scientists who will learn how to rationally design a next generation of well-defined and innovative glycoconjugate vaccines to improve current preventive therapies and to tackle unmet medical needs. Glycoconjugate vaccines represent the key for success of vaccination in children. The covalent linkage to proteins renders carbohydrates able to evoke a T-cell memory response. Current vaccines are prepared from heterogeneous mixtures of sugars linked by unspecific methods to the carrier protein giving complex mixtures of products. Due to this intricate structure, it has not been possible to apply a medicinal chemistry approach in the development of glycoconjugate vaccines and to fully understand their mechanism of action. Combination of novel approaches for glycan synthesis and site-selective conjugation methods now gives access to conjugates defined in sugar component and attachment site, thus leading to robust structure-immunogenicity relationship. Advancements in structural biophysics can be applied to select the optimal glycan antigen. By combining the beneficiaries’ expertise in carbohydrate synthesis, bioconjugation, high throughput screening, structural glycobiology, vaccinology and immunology, together with the experience in project management, GLYCOVAX will create a multidisciplinary environment where 14 young researchers will contribute to develop a novel route towards improved, safer and better characterized glycoconjugate vaccines, and contemporarily acquire transferable skills which will lead them to become the new leaders of academic or industrial research. The network will involve 9 academic groups and 2 industrial partners as Beneficiaries, and one SME as Partner Organization. The profound interaction between academy and industry will aid the students to get new concepts and visions for translating their ideas from the bench to the manufacturing of the next generation of glycoconjugate vaccines.

 Deliverables

List of deliverables.
Local Training Documents, reports 2020-03-06 16:14:26
Glycoscience workshops Documents, reports 2020-02-12 17:16:50
Annual GLYCOVAX symposiums Documents, reports 2020-02-07 15:50:47
CTS Documents, reports 2020-02-07 15:50:47
Plan for using and disseminating knowledge Websites, patent fillings, videos etc. 2020-02-07 15:50:48
PhD Documents, reports 2020-02-07 15:50:44
Reports on public engagement activities Documents, reports 2020-02-07 15:50:49
Call publication Other 2019-09-06 08:53:52
Website Websites, patent fillings, videos etc. 2019-09-06 08:53:53

Take a look to the deliverables list in detail:  detailed list of GLYCOVAX deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Roberto Adamo, Davide Oldrini, Linda del Bino, Ana Arda, Filippo Carboni, Pedro Henriques, Francesca Angiolini, Jon I. Quintana, Ilaria Calloni, Maria R. Romano, Francesco Berti, Jesus Jimenez Barbero, Immaculada Margarit
Structure‐guided design of a Group B Streptococcus type III synthetic glycan‐conjugate vaccine
published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.202000284
Chemistry – A European Journal 2020-03-10
2018 Cinzia Colombo, Olimpia Pitirollo, Luigi Lay
Recent Advances in the Synthesis of Glycoconjugates for Vaccine Development
published pages: 1712, ISSN: 1420-3049, DOI: 10.3390/molecules23071712
Molecules 23/7 2020-01-30
2019 F Romero-Saavedra, D Laverde, E Kalfopoulou, C Martini, R Torelli, D Martinez-Matamoros, M Sanguinetti, J Huebner
Conjugation of Different Immunogenic Enterococcal Vaccine Target Antigens Leads to Extended Strain Coverage
published pages: 1589-1598, ISSN: 0022-1899, DOI: 10.1093/infdis/jiz357
The Journal of Infectious Diseases 220/10 2019-11-07
2019 Ermioni Kalfopoulou, Diana Laverde, Karmela Miklic, Felipe Romero-Saavedra, Suzana Malic, Filippo Carboni, Roberto Adamo, Tihana Lenac Rovis, Stipan Jonjic, Johannes Huebner
Development of Opsonic Mouse Monoclonal Antibodies against Multidrug-Resistant Enterococci
published pages: , ISSN: 0019-9567, DOI: 10.1128/iai.00276-19
Infection and Immunity 87/9 2019-11-07
2018 Tetiana Dumych, Nao Yamakawa, Adeline Sivignon, Estelle Garenaux, Stefania Robakiewicz, Bernadette Coddeville, Antonino Bongiovanni, Fabrice Bray, Nicolas Barnich, Sabine Szunerits, Christian Slomianny, Martin Herrmann, Sébastien G. Gouin, Alexander D. Lutsyk, Luis E. Munoz, Frank Lafont, Christian Rolando, Rostyslav Bilyy, Julie M. J. Bouckaert
Oligomannose-Rich Membranes of Dying Intestinal Epithelial Cells Promote Host Colonization by Adherent-Invasive E. coli
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2018.00742
Frontiers in Microbiology 9 2019-11-07
2019 Francesca Micoli, Linda Del Bino, Renzo Alfini, Filippo Carboni, Maria Rosaria Romano, Roberto Adamo
Glycoconjugate vaccines: current approaches towards faster vaccine design
published pages: 881-895, ISSN: 1476-0584, DOI: 10.1080/14760584.2019.1657012
Expert Review of Vaccines 18/9 2019-11-07
2018 Claudia Kohout, Cristina Santi, Laura Polito
Anisotropic Gold Nanoparticles in Biomedical Applications
published pages: 3385, ISSN: 1422-0067, DOI: 10.3390/ijms19113385
International Journal of Molecular Sciences 19/11 2019-11-07
2018 Daan van der Es, Francesca Berni, Wouter F. J. Hogendorf, Nico Meeuwenoord, Diana Laverde, Angela van Diepen, Herman S. Overkleeft, Dmitri V. Filippov, Cornelis H. Hokke, Johannes Huebner, Gijsbert A. van der Marel, Jeroen D. C. Codée
Streamlined Synthesis and Evaluation of Teichoic Acid Fragments
published pages: 4014-4018, ISSN: 0947-6539, DOI: 10.1002/chem.201800153
Chemistry - A European Journal 24/16 2019-09-06
2018 Ilaria Calloni, Luca Unione, Gonzalo Jiménez-Osés, Francisco Corzana, Linda Del Bino, Alessio Corrado, Olimpia Pitirollo, Cinzia Colombo, Luigi Lay, Roberto Adamo, Jesús Jiménez-Barbero
The Conformation of the Mannopyranosyl Phosphate Repeating Unit of the Capsular Polysaccharide of Neisseria meningitidis Serogroup A and Its Carba-Mimetic
published pages: 4548-4555, ISSN: 1434-193X, DOI: 10.1002/ejoc.201801003
European Journal of Organic Chemistry 2018/33 2019-09-06
2018 Francesco Berti, Roberto Adamo
Antimicrobial glycoconjugate vaccines: an overview of classic and modern approaches for protein modification
published pages: , ISSN: 0306-0012, DOI: 10.1039/c8cs00495a
Chemical Society Reviews 2019-09-06

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