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RuMicroPlas SIGNED

The Plasmidome: a Driving Force of Rumen Microbial Evolution from Birth to Adulthood

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Project "RuMicroPlas" data sheet

The following table provides information about the project.

Coordinator
BEN-GURION UNIVERSITY OF THE NEGEV 

Organization address
address: .
city: BEER SHEVA
postcode: 84105
website: www.bgu.ac.il

contact info
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name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Israel [IL]
 Total cost 1˙499˙000 €
 EC max contribution 1˙499˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BEN-GURION UNIVERSITY OF THE NEGEV IL (BEER SHEVA) coordinator 1˙499˙000.00

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 Project objective

Plasmids are known to be major contributors to lateral gene transfer in bacterial genomes; however, their comprehensive evolutionary role within bacterial communities is poorly understood. Recently we have developed cutting edge abilities to access a plasmid population (plasmidome) of a given microbial community, and applied them to rumen microbial communities. These abilities are an element long-needed for the study of microbial lateral gene transfer and evolution. Ruminants house a highly complex microbial community in the rumen compartment of their digestive tract, with which they have evolved into an obligatory co-dependence. Its confined nature provides a perfect system for the study of evolutionary dynamics within microbial communities. Here we propose to study the evolutionary and ecological dynamics of the rumen plasmidome and its interaction with the rumen microbiome using our established approaches, together with a dense host-sampling resolution. We aim to understand the origins and assembly of these two entities, as well as their interactions with each other. We will explore the effect of early assemblages on the adult plasmidome and microbiome phenotypes. To complement the overview of global trends, we will study local interactions among individual rumen plasmids with their microbial host's genome and physiology at the single-plasmid level. These two distinct perspectives will allow us to understand the role played by plasmids within this complex microbial community, the co-evolutionary relationships between these two entities and their importance to the overall rumen ecosystem. Based on a plasmid-centric approach, this study bears the unique ability to examine lateral gene transfer in “real time” by following genes on their transfer “vehicles”, and providing new insights into the fine details of microbial evolution. Its goals, many challenges and new approach place this proposal at the cutting edge of current research in microbial ecology and evolution.

 Publications

year authors and title journal last update
List of publications.
2017 Goor Sasson, Sheerli Kruger Ben-Shabat, Eyal Seroussi, Adi Doron-Faigenboim, Naama Shterzer, Shamay Yaacoby, Margret E. Berg Miller, Bryan A. White, Eran Halperin, Itzhak Mizrahi
Heritable Bovine Rumen Bacteria Are Phylogenetically Related and Correlated with the Cow’s Capacity To Harvest Energy from Its Feed
published pages: , ISSN: 2150-7511, DOI: 10.1128/mBio.00703-17
mBio 8/4 2019-04-18
2016 Roye Rozov, Aya Brown Kav, David Bogumil, Naama Shterzer, Eran Halperin, Itzhak Mizrahi, Ron Shamir
Recycler: an algorithm for detecting plasmids from de novo assembly graphs
published pages: btw651, ISSN: 1367-4803, DOI: 10.1093/bioinformatics/btw651
Bioinformatics 2019-04-18
2018 Yoav Shaani, Tamar Zehavi, Stav Eyal, Joshuah Miron, Itzhak Mizrahi
Microbiome niche modification drives diurnal rumen community assembly, overpowering individual variability and diet effects
published pages: 2446-2457, ISSN: 1751-7362, DOI: 10.1038/s41396-018-0203-0
The ISME Journal 12/10 2019-04-18
2016 Sheerli Kruger Ben Shabat, Goor Sasson, Adi Doron-Faigenboim, Thomer Durman, Shamay Yaacoby, Margret E Berg Miller, Bryan A White, Naama Shterzer, Itzhak Mizrahi
Specific microbiome-dependent mechanisms underlie the energy harvest efficiency of ruminants
published pages: 2958-2972, ISSN: 1751-7362, DOI: 10.1038/ismej.2016.62
The ISME Journal 10/12 2019-04-18
2018 Fotini Kokou, Goor Sasson, Tali Nitzan, Adi Doron-Faigenboim, Sheenan Harpaz, Avner Cnaani, Itzhak Mizrahi
Host genetic selection for cold tolerance shapes microbiome composition and modulates its response to temperature
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.36398
eLife 7 2019-04-18
2019 Sarah Moraïs, Itzhak Mizrahi
The Road Not Taken: The Rumen Microbiome, Functional Groups, and Community States
published pages: , ISSN: 0966-842X, DOI: 10.1016/j.tim.2018.12.011
Trends in Microbiology 2019-02-26

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