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KidsAP SIGNED

The artificial pancreas in children aged 1 to 7 years with type 1 diabetes

Total Cost €

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EC-Contrib. €

0

Partnership

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Project "KidsAP" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://kidsap.mrl.ims.cam.ac.uk/
 Total cost 4˙952˙796 €
 EC max contribution 4˙637˙477 € (94%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2016-RTD
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙567˙828.00
2    MEDIZINISCHE UNIVERSITAT GRAZ AT (GRAZ) participant 441˙191.00
3    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) participant 430˙275.00
4    CENTRE HOSPITALIER DE LUXEMBOURG LU (LUXEMBOURG) participant 399˙025.00
5    MEDIZINISCHE UNIVERSITAT INNSBRUCK AT (INNSBRUCK) participant 399˙025.00
6    THE LEEDS TEACHING HOSPITALS NATIONAL HEALTH SERVICE TRUST UK (LEEDS) participant 399˙025.00
7    UNIVERSITAET LEIPZIG DE (LEIPZIG) participant 399˙025.00
8    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) participant 325˙458.00
9    DIASEND AB SE (ASKIM) participant 182˙843.00
10    HEVA HEOR FR (LYON) participant 93˙780.00
11    JAEB CENTER FOR HEALTH RESEARCH FOUNDATION INC US (TAMPA) participant 0.00

Map

 Project objective

TYPE 1 DIABETES is one of the most COMMON CHRONIC diseases in children with a RAPID increase in number of cases particularly in young children. Type 1 diabetes is associated with LIFE-LONG dependency on insulin administration. POOR glucose control leads to diabetes COMPLICATIONS, e.g. eye, heart, kidney disease, including BRAIN changes in young children. Episodes of VERY LOW glucose levels may be life threatening and are a major complication.

The ARTIFICIAL PANCREAS addresses the problem of LOW and HIGH glucose levels by delivering insulin BELOW and ABOVE pre-set amounts according to real-time sensor GLUCOSE levels, combining glucose SENSOR, insulin PUMP, and CONTROL ALGORITHM. The Artificial pancreas promises to TRANSFORM management of type 1 diabetes but EVIDENCE supporting its use during FREE LIVING in YOUNG CHILDREN is MISSING.

The project evaluates the biomedical, psychosocial, and cost effectiveness of NOVEL INDIVIDUALISED artificial pancreas in young children aged 1 to 7 years with type 1 diabetes. Following a PILOT (n=24), in the MAIN study (n=94) half of the participants (n=47) will be treated over 12 MONTHS by the ARTIFICIAL PANCREAS and the other half (n=47) by STATE-OF-THE-ART PREDICTIVE LOW GLUCOSE MANAGEMENT insulin pump therapy. Each treatment will last ONE YEAR. QUALITY OF LIFE will be assessed and semi-structured INTERVIEWS conducted to understand the impact on daily life. HEALTH TECHNOLOGY ASSESSMENT will support reimbursement.

The project will OPTIMISE artificial pancreas and SPEARHEAD SYSTEM-WIDE improvements in health care quality and health outcomes in YOUNG CHILDERN with TYPE 1 DIABETES who live with the disease LONGEST. By IMPROVING THERAPEUTIC OUTCOMES, the project will CHANGE clinical practice and INFLUENCE national and international treatment guidelines making the artificial pancreas WIDELY ACCEPTABLE as the state-of-art treatment modality in young children.

 Deliverables

List of deliverables.
Public project website online Websites, patent fillings, videos etc. 2020-04-08 14:17:31

Take a look to the deliverables list in detail:  detailed list of KidsAP deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Martin Tauschmann, Janet M. Allen, Katrin Nagl, Maria Fritsch, James Yong, Emily Metcalfe, Dominique Schaeffer, Muriel Fichelle, Ulrike Schierloh, Alena G. Thiele, Daniela Abt, Harald Kojzar, Julia K. Mader, Sonja Slegtenhorst, Nicole Barber, Malgorzata E. Wilinska, Charlotte Boughton, Gianluca Musolino, Judy Sibayan, Nathan Cohen, Craig Kollman, Sabine E. Hofer, Elke Fröhlich-Reiterer, Thomas M.
Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Very Young Children: A Multicenter, 3-Week, Randomized Trial
published pages: 594-600, ISSN: 0149-5992, DOI: 10.2337/dc18-1881
Diabetes Care 42/4 2020-04-08
2019 Klemen Dovc, Charlotte Boughton, Martin Tauschmann, Hood Thabit, Lia Bally, Janet M. Allen, Carlo L. Acerini, Sabine Arnolds, Carine de Beaufort, Richard M. Bergenstal, Fiona Campbell, Amy Criego, David B. Dunger, Daniella Elleri, Mark L. Evans, Elke Fröhlich-Reiterer, Sabine Hofer, Thomas Kapellen, Lalantha Leelarathna, Thomas R. Pieber, Birgit Rami-Merhar, Viral N. Shah, Judy Sibayan, Malgorzat
Young Children Have Higher Variability of Insulin Requirements: Observations During Hybrid Closed-Loop Insulin Delivery
published pages: 1344-1347, ISSN: 0149-5992, DOI: 10.2337/dc18-2625
Diabetes Care 42/7 2020-04-08
2019 Gianluca Musolino, Klemen Dovc, Charlotte K. Boughton, Martin Tauschmann, Janet M. Allen, Katrin Nagl, Maria Fritsch, James Yong, Emily Metcalfe, Dominique Schaeffer, Muriel Fichelle, Ulrike Schierloh, Alena G. Thiele, Daniela Abt, Harald Kojzar, Julia K. Mader, Sonja Slegtenhorst, Nicole Ashcroft, Malgorzata E. Wilinska, Judy Sibayan, Nathan Cohen, Craig Kollman, Sabine E. Hofer, Elke Fröhlich
Reduced burden of diabetes and improved quality of life: Experiences from unrestricted day‐and‐night hybrid closed‐loop use in very young children with type 1 diabetes
published pages: , ISSN: 1399-543X, DOI: 10.1111/pedi.12872
Pediatric Diabetes 2020-04-08

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The information about "KIDSAP" are provided by the European Opendata Portal: CORDIS opendata.

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