Explore the words cloud of the IXSI3D project. It provides you a very rough idea of what is the project "IXSI3D" about.
The following table provides information about the project.
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
|Coordinator Country||Netherlands [NL]|
|Total cost||1˙999˙000 €|
|EC max contribution||1˙999˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-12-01 to 2020-11-30|
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|1||UNIVERSITAIR MEDISCH CENTRUM UTRECHT||NL (UTRECHT)||coordinator||1˙999˙000.00|
I propose to research, build and evaluate Interventional X-ray and Scintigraphy Imaging (IXSI). This will provide for the first time real-time, multimodality imaging during medical interventions by combining live x-ray and live nuclear imaging simultaneously from an identical viewpoint. The hybrid x-ray/nuclear imaging device will enable surgeons and interventional radiologists to exploit the power of molecular imaging in the operating theatre and intervention room through i) live guidance using 2D imaging and ii) 3D quantitative evaluation (IXSI3D). Systems, like the successful PET/CT and SPECT/CT, have revolutionized diagnostic medical imaging; however they acquire x-ray (anatomical information) and nuclear images (molecular information) in sequence. Our new technology brings live, hybrid imaging to operations and interventions. This will have a broad and powerful impact, particularly in oncological applications, including internal radiotherapy, tumor resection and biopsies. For combined X-ray/nuclear imaging, an x-ray tube, an x-ray detector and a gamma camera with collimator are required. Our concept relies on placing these three elements in one line, thus enabling imaging of the same field-of-view. However, straight-forward combination of these elements would block the line of views. Inspired by how eyes see around the nose, I invented a gamma camera geometry that sees around the x-ray tube. I have created a prototype, and using a provisional set-up based on this novel concept (patent pending), I have demonstrated IXSI’s basic principles. This proposal describes the quantum leap in medical imaging: clinical realization of IXSI for guidance, and the development of IXSI3D that enables intra-operative quantitative evaluation. I will develop algorithms and hardware, build a mobile system and prove it’s potential in a clinical research protocol. This will be the start of a new era in image-guided intervention.
|year||authors and title||journal||last update|
W J C Koppert, S van der Velden, J H L Steenbergen, H W A M de Jong
Impact of intense x-ray pulses on a NaI(Tl)-based gamma camera
published pages: 65006, ISSN: 1361-6560, DOI: 10.1088/1361-6560/aaaf02
|Physics in Medicine & Biology 63/6||2019-05-30|
Casper Beijst, Britt Kunnen, Marnix G.E.H. Lam, Hugo W.A.M. de Jong
Technical Advances in Image Guidance of Radionuclide Therapy
published pages: 272-279, ISSN: 0091-4916, DOI: 10.2967/jnmt.117.190991
|Journal of Nuclear Medicine Technology 45/4||2019-05-30|
Maarten L. J. Smits, Remco Bastiaannet, Jip F. Prince, Hugo W. A. M. de Jong, Maurice A. A. J. van den Bosch, Marnix G. E. H. Lam
Lung Shunting: An Indicator of Survival, But Not Necessarily a Tool for Selecting Patients for Radioembolization
published pages: 612-613, ISSN: 0033-8419, DOI: 10.1148/radiol.2017162087
Remco Bastiaannet, Max A. Viergever, Hugo W. A. M. de Jong
Impact of respiratory motion and acquisition settings on SPECT liver dosimetry for radioembolization
published pages: 5270-5279, ISSN: 0094-2405, DOI: 10.1002/mp.12483
|Medical Physics 44/10||2019-05-30|
B.J. van Nierop, J.F. Prince, R. van Rooij, M.A.A.J. van den Bosch, M.G.E.H. Lam, H.W.A.M. de Jong
Accuracy of SPECT/CT based lung dose calculation for Holmium-166 hepatic radioembolization before OSEM convergence
published pages: , ISSN: 0094-2405, DOI: 10.1002/mp.13024
Sandra van der Velden, Remco Bastiaannet, Arthur J A T Braat, Marnix G E H Lam, Max A Viergever, Hugo W A M de Jong
Estimation of lung shunt fraction from simultaneous fluoroscopic and nuclear images
published pages: 8210-8225, ISSN: 1361-6560, DOI: 10.1088/1361-6560/aa8840
|Physics in Medicine & Biology 62/21||2019-05-30|
Sandra van der Velden, Casper Beijst, Max A. Viergever, Hugo W. A. M. de Jong
Simultaneous fluoroscopic and nuclear imaging: impact of collimator choice on nuclear image quality
published pages: 249-261, ISSN: 0094-2405, DOI: 10.1002/mp.12010
|Medical Physics 44/1||2019-05-30|
Casper Beijst, Mattijs Elschot, Sandra van der Velden, Hugo W. A. M. de Jong
Multimodality calibration for simultaneous fluoroscopic and nuclear imaging
published pages: , ISSN: 2197-7364, DOI: 10.1186/s40658-016-0156-1
|EJNMMI Physics 3/1||2019-05-30|
Sandra van der Velden, Martijn M. A. Dietze, Max A. Viergever, Hugo W. A. M. de Jong
Fast technetium-99m liver SPECT for evaluation of the pretreatment procedure for radioembolization dosimetry
published pages: 345-355, ISSN: 0094-2405, DOI: 10.1002/mp.13253
|Medical Physics 46/1||2019-04-19|
Martijn M. A. Dietze, Sandra van der Velden, Marnix G. E. H. Lam, Max A. Viergever, Hugo W. A. M. de Jong
Fast quantitative reconstruction with focusing collimators for liver SPECT
published pages: , ISSN: 2197-7364, DOI: 10.1186/s40658-018-0228-5
|EJNMMI Physics 5/1||2019-04-19|
Remco Bastiaannet, Caren van Roekel, Britt Kunnen, Marnix G. E. H. Lam, Hugo W. A. M. de Jong
Is Diffusion-weighted MRI Really Superior to PET/CT in Predicting Survival after Radioembolization?
published pages: 274-275, ISSN: 0033-8419, DOI: 10.1148/radiol.2018181348
Manon N. G. J. A. Braat, Hugo W. de Jong, Beatrijs A. Seinstra, Mike V. Scholten, Maurice A. A. J. van den Bosch, Marnix G. E. H. Lam
Hepatobiliary scintigraphy may improve radioembolization treatment planning in HCC patients
published pages: , ISSN: 2191-219X, DOI: 10.1186/s13550-016-0248-x
|EJNMMI Research 7/1||2019-04-19|
Remco Bastiaannet, S. Cheenu Kappadath, Britt Kunnen, Arthur J. A. T. Braat, Marnix G. E. H. Lam, Hugo W. A. M. de Jong
The physics of radioembolization
published pages: , ISSN: 2197-7364, DOI: 10.1186/s40658-018-0221-z
|EJNMMI Physics 5/1||2019-04-19|
Britt Kunnen, Sandra van der Velden, Remco Bastiaannet, Marnix G. E. H. Lam, Max A. Viergever, Hugo W. A. M. de Jong
Radioembolization lung shunt estimation based on a 90 Y pretreatment procedure: A phantom study
published pages: 4744-4753, ISSN: 0094-2405, DOI: 10.1002/mp.13168
|Medical Physics 45/10||2019-04-19|
Sandra van der Velden, Britt Kunnen, Wilco J. C. Koppert, Johannes H. L. Steenbergen, Martijn M. A. Dietze, Casper Beijst, Max A. Viergever, Marnix G. E. H. Lam, Hugo W. A. M. de Jong
A Dual-layer Detector for Simultaneous Fluoroscopic and Nuclear Imaging
published pages: 833-838, ISSN: 0033-8419, DOI: 10.1148/radiol.2018180796
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