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Translating Hybrid Imaging for Interventions: Intra-operative Guidance and Evaluation using 2D and 3D Interventional X-ray Scintigraphy Imaging

Total Cost €


EC-Contrib. €






 IXSI3D project word cloud

Explore the words cloud of the IXSI3D project. It provides you a very rough idea of what is the project "IXSI3D" about.

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Project "IXSI3D" data sheet

The following table provides information about the project.


Organization address
postcode: 3584 CX

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 1˙999˙000 €
 EC max contribution 1˙999˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-12-01   to  2020-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

I propose to research, build and evaluate Interventional X-ray and Scintigraphy Imaging (IXSI). This will provide for the first time real-time, multimodality imaging during medical interventions by combining live x-ray and live nuclear imaging simultaneously from an identical viewpoint. The hybrid x-ray/nuclear imaging device will enable surgeons and interventional radiologists to exploit the power of molecular imaging in the operating theatre and intervention room through i) live guidance using 2D imaging and ii) 3D quantitative evaluation (IXSI3D). Systems, like the successful PET/CT and SPECT/CT, have revolutionized diagnostic medical imaging; however they acquire x-ray (anatomical information) and nuclear images (molecular information) in sequence. Our new technology brings live, hybrid imaging to operations and interventions. This will have a broad and powerful impact, particularly in oncological applications, including internal radiotherapy, tumor resection and biopsies. For combined X-ray/nuclear imaging, an x-ray tube, an x-ray detector and a gamma camera with collimator are required. Our concept relies on placing these three elements in one line, thus enabling imaging of the same field-of-view. However, straight-forward combination of these elements would block the line of views. Inspired by how eyes see around the nose, I invented a gamma camera geometry that sees around the x-ray tube. I have created a prototype, and using a provisional set-up based on this novel concept (patent pending), I have demonstrated IXSI’s basic principles. This proposal describes the quantum leap in medical imaging: clinical realization of IXSI for guidance, and the development of IXSI3D that enables intra-operative quantitative evaluation. I will develop algorithms and hardware, build a mobile system and prove it’s potential in a clinical research protocol. This will be the start of a new era in image-guided intervention.


year authors and title journal last update
List of publications.
2018 W J C Koppert, S van der Velden, J H L Steenbergen, H W A M de Jong
Impact of intense x-ray pulses on a NaI(Tl)-based gamma camera
published pages: 65006, ISSN: 1361-6560, DOI: 10.1088/1361-6560/aaaf02
Physics in Medicine & Biology 63/6 2019-05-30
2017 Casper Beijst, Britt Kunnen, Marnix G.E.H. Lam, Hugo W.A.M. de Jong
Technical Advances in Image Guidance of Radionuclide Therapy
published pages: 272-279, ISSN: 0091-4916, DOI: 10.2967/jnmt.117.190991
Journal of Nuclear Medicine Technology 45/4 2019-05-30
2017 Maarten L. J. Smits, Remco Bastiaannet, Jip F. Prince, Hugo W. A. M. de Jong, Maurice A. A. J. van den Bosch, Marnix G. E. H. Lam
Lung Shunting: An Indicator of Survival, But Not Necessarily a Tool for Selecting Patients for Radioembolization
published pages: 612-613, ISSN: 0033-8419, DOI: 10.1148/radiol.2017162087
Radiology 282/2 2019-05-30
2017 Remco Bastiaannet, Max A. Viergever, Hugo W. A. M. de Jong
Impact of respiratory motion and acquisition settings on SPECT liver dosimetry for radioembolization
published pages: 5270-5279, ISSN: 0094-2405, DOI: 10.1002/mp.12483
Medical Physics 44/10 2019-05-30
2018 B.J. van Nierop, J.F. Prince, R. van Rooij, M.A.A.J. van den Bosch, M.G.E.H. Lam, H.W.A.M. de Jong
Accuracy of SPECT/CT based lung dose calculation for Holmium-166 hepatic radioembolization before OSEM convergence
published pages: , ISSN: 0094-2405, DOI: 10.1002/mp.13024
Medical Physics 2019-05-30
2017 Sandra van der Velden, Remco Bastiaannet, Arthur J A T Braat, Marnix G E H Lam, Max A Viergever, Hugo W A M de Jong
Estimation of lung shunt fraction from simultaneous fluoroscopic and nuclear images
published pages: 8210-8225, ISSN: 1361-6560, DOI: 10.1088/1361-6560/aa8840
Physics in Medicine & Biology 62/21 2019-05-30
2017 Sandra van der Velden, Casper Beijst, Max A. Viergever, Hugo W. A. M. de Jong
Simultaneous fluoroscopic and nuclear imaging: impact of collimator choice on nuclear image quality
published pages: 249-261, ISSN: 0094-2405, DOI: 10.1002/mp.12010
Medical Physics 44/1 2019-05-30
2016 Casper Beijst, Mattijs Elschot, Sandra van der Velden, Hugo W. A. M. de Jong
Multimodality calibration for simultaneous fluoroscopic and nuclear imaging
published pages: , ISSN: 2197-7364, DOI: 10.1186/s40658-016-0156-1
EJNMMI Physics 3/1 2019-05-30
2019 Sandra van der Velden, Martijn M. A. Dietze, Max A. Viergever, Hugo W. A. M. de Jong
Fast technetium-99m liver SPECT for evaluation of the pretreatment procedure for radioembolization dosimetry
published pages: 345-355, ISSN: 0094-2405, DOI: 10.1002/mp.13253
Medical Physics 46/1 2019-04-19
2018 Martijn M. A. Dietze, Sandra van der Velden, Marnix G. E. H. Lam, Max A. Viergever, Hugo W. A. M. de Jong
Fast quantitative reconstruction with focusing collimators for liver SPECT
published pages: , ISSN: 2197-7364, DOI: 10.1186/s40658-018-0228-5
EJNMMI Physics 5/1 2019-04-19
2018 Remco Bastiaannet, Caren van Roekel, Britt Kunnen, Marnix G. E. H. Lam, Hugo W. A. M. de Jong
Is Diffusion-weighted MRI Really Superior to PET/CT in Predicting Survival after Radioembolization?
published pages: 274-275, ISSN: 0033-8419, DOI: 10.1148/radiol.2018181348
Radiology 289/1 2019-04-19
2017 Manon N. G. J. A. Braat, Hugo W. de Jong, Beatrijs A. Seinstra, Mike V. Scholten, Maurice A. A. J. van den Bosch, Marnix G. E. H. Lam
Hepatobiliary scintigraphy may improve radioembolization treatment planning in HCC patients
published pages: , ISSN: 2191-219X, DOI: 10.1186/s13550-016-0248-x
EJNMMI Research 7/1 2019-04-19
2018 Remco Bastiaannet, S. Cheenu Kappadath, Britt Kunnen, Arthur J. A. T. Braat, Marnix G. E. H. Lam, Hugo W. A. M. de Jong
The physics of radioembolization
published pages: , ISSN: 2197-7364, DOI: 10.1186/s40658-018-0221-z
EJNMMI Physics 5/1 2019-04-19
2018 Britt Kunnen, Sandra van der Velden, Remco Bastiaannet, Marnix G. E. H. Lam, Max A. Viergever, Hugo W. A. M. de Jong
Radioembolization lung shunt estimation based on a 90 Y pretreatment procedure: A phantom study
published pages: 4744-4753, ISSN: 0094-2405, DOI: 10.1002/mp.13168
Medical Physics 45/10 2019-04-19
2019 Sandra van der Velden, Britt Kunnen, Wilco J. C. Koppert, Johannes H. L. Steenbergen, Martijn M. A. Dietze, Casper Beijst, Max A. Viergever, Marnix G. E. H. Lam, Hugo W. A. M. de Jong
A Dual-layer Detector for Simultaneous Fluoroscopic and Nuclear Imaging
published pages: 833-838, ISSN: 0033-8419, DOI: 10.1148/radiol.2018180796
Radiology 290/3 2019-04-19

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