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NOVEL SIGNED

Emergence of novel phenotypes in co-evolving biological systems: allelic diversification and dominance at the Self-incompatibility locus in Arabidopsis.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NOVEL project word cloud

Explore the words cloud of the NOVEL project. It provides you a very rough idea of what is the project "NOVEL" about.

jointly    dominance    unveil    sequences    biology    recessivity    question    course    whereby    intricate    evolutionary    emergence    genes    empirical    delicto    arise    interact    threefold    poorly    species    components    individual    decrypt    reproductive    arabidopsis    female    diversification    organization    closely    coding    alphabet    basic    sites    model    transgenic    male    fundamental    population    protein    place    underlying    sporophytic    organisms    ancestral    pollen    coordinated    biological    powerful    parts    interactions    rejection    combining    combination    interaction    phenotypic    constraints    nucleotide    populations    proteins    fitness    self    fraction    nature    alleles    theoretical    co    mechanistic    plants    fine    functional    natural    lacking    outcrossing    phenotype    evolve    molecular    tractable    predict    raises    ecological    genetics    levels    context    flagrante    genomics    manner    small    landscapes    catch    entails    revealing    multidisciplinary    incompatibility    regulatory    resurrection    evolution    rnas    novelty    variation    recognition   

Project "NOVEL" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://vincentcastric.weebly.com
 Total cost 1˙760˙880 €
 EC max contribution 1˙760˙880 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙760˙880.00

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 Project objective

The emerging field of systems biology is revealing the intricate nature of biological organisms, whereby a large fraction of their individual components (genes, proteins, regulatory elements) interact with several others. The co-evolutionary processes that this entails raises the question of how phenotypic novelty may arise in the course of evolution, since all parts of the system have to evolve in a coordinated manner if the phenotype is to remain functional. For most biological systems, however, we are lacking even basic insight into the fine-scale mechanistic constraints and the underlying ecological context. In this project, we will focus on the sporophytic self-incompatibility system in outcrossing Arabidopsis species, a model biological system in which two distinct co-evolutionary processes are becoming well-understood: 1) between the male and female reproductive proteins allowing self-pollen recognition and rejection and 2) between small non-coding RNAs and their target sites that jointly control the dominance/recessivity interactions between self-incompatibility alleles. By studying these two model systems, we will aim to catch the emergence of functional and regulatory novelty in flagrante delicto. We will take a multidisciplinary approach combining theoretical and empirical population genetics, evolutionary genomics and ancestral protein resurrection using transgenic plants. Our goal is threefold: 1) decrypt the molecular alphabet of the interaction between co-evolving nucleotide sequences, 2) predict and evaluate the fitness landscapes upon which the two co-evolutionary processes are taking place and 3) exploit natural variation in closely related species to unveil the kind of co-evolutionary process in natural populations. Our combination of various powerful approaches in a tractable model system should provide insight on diversification, a poorly understood but fundamental evolutionary process that is taking place at all levels of organization.

 Publications

year authors and title journal last update
List of publications.
2017 Pierre Saumitou-Laprade, Philippe Vernet, Xavier Vekemans, Vincent Castric, Gianni Barcaccia, Bouchaïb Khadari, Luciana Baldoni
Controlling for genetic identity of varieties, pollen contamination and stigma receptivity is essential to characterize the self-incompatibility system of Olea europaea L.
published pages: 860-866, ISSN: 1752-4571, DOI: 10.1111/eva.12498
Evolutionary Applications 10/9 2020-04-23
2017 Sier-Ching Chantha, Adam C. Herman, Vincent Castric, Xavier Vekemans, William Marande, Daniel J. Schoen
The unusual S locus of Leavenworthia is composed of two sets of paralogous loci
published pages: 1247-1255, ISSN: 0028-646X, DOI: 10.1111/nph.14764
New Phytologist 216/4 2020-04-23
2017 Takashi Tsuchimatsu, Pauline M. Goubet, Sophie Gallina, Anne-Catherine Holl, Isabelle Fobis-Loisy, Hélène Bergès, William Marande, Elisa Prat, Dazhe Meng, Quan Long, Alexander Platzer, Magnus Nordborg, Xavier Vekemans, Vincent Castric
Patterns of Polymorphism at the Self-Incompatibility Locus in 1,083 Arabidopsis thaliana Genomes
published pages: , ISSN: 0737-4038, DOI: 10.1093/molbev/msx122
Molecular Biology and Evolution 2020-04-23
2017 Polina Yu. Novikova, Takashi Tsuchimatsu, Samson Simon, Viktoria Nizhynska, Viktor Voronin, Robin Burns, Olga M. Fedorenko, Svante Holm, Torbjörn Säll, Elisa Prat, William Marande, Vincent Castric, Magnus Nordborg
Genome sequencing reveals the origin of the allotetraploid Arabidopsis suecica
published pages: msw299, ISSN: 0737-4038, DOI: 10.1093/molbev/msw299
Molecular Biology and Evolution 2020-04-23

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