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Emergence of novel phenotypes in co-evolving biological systems: allelic diversification and dominance at the Self-incompatibility locus in Arabidopsis.

Total Cost €


EC-Contrib. €






 NOVEL project word cloud

Explore the words cloud of the NOVEL project. It provides you a very rough idea of what is the project "NOVEL" about.

novelty    evolution    raises    protein    recognition    intricate    evolutionary    outcrossing    coordinated    variation    constraints    regulatory    interaction    components    arabidopsis    parts    self    fraction    landscapes    genes    underlying    model    arise    male    entails    incompatibility    course    rejection    rnas    jointly    sequences    coding    dominance    sporophytic    co    phenotype    nature    decrypt    poorly    revealing    populations    fine    context    whereby    transgenic    threefold    individual    functional    combining    question    diversification    proteins    delicto    fundamental    plants    molecular    emergence    manner    empirical    organization    reproductive    nucleotide    closely    unveil    tractable    flagrante    theoretical    combination    basic    genomics    lacking    recessivity    alphabet    small    place    organisms    powerful    ancestral    interact    population    natural    evolve    biology    female    pollen    mechanistic    multidisciplinary    fitness    alleles    catch    interactions    species    ecological    levels    resurrection    genetics    predict    phenotypic    biological    sites   

Project "NOVEL" data sheet

The following table provides information about the project.


Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website
 Total cost 1˙760˙880 €
 EC max contribution 1˙760˙880 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2020-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The emerging field of systems biology is revealing the intricate nature of biological organisms, whereby a large fraction of their individual components (genes, proteins, regulatory elements) interact with several others. The co-evolutionary processes that this entails raises the question of how phenotypic novelty may arise in the course of evolution, since all parts of the system have to evolve in a coordinated manner if the phenotype is to remain functional. For most biological systems, however, we are lacking even basic insight into the fine-scale mechanistic constraints and the underlying ecological context. In this project, we will focus on the sporophytic self-incompatibility system in outcrossing Arabidopsis species, a model biological system in which two distinct co-evolutionary processes are becoming well-understood: 1) between the male and female reproductive proteins allowing self-pollen recognition and rejection and 2) between small non-coding RNAs and their target sites that jointly control the dominance/recessivity interactions between self-incompatibility alleles. By studying these two model systems, we will aim to catch the emergence of functional and regulatory novelty in flagrante delicto. We will take a multidisciplinary approach combining theoretical and empirical population genetics, evolutionary genomics and ancestral protein resurrection using transgenic plants. Our goal is threefold: 1) decrypt the molecular alphabet of the interaction between co-evolving nucleotide sequences, 2) predict and evaluate the fitness landscapes upon which the two co-evolutionary processes are taking place and 3) exploit natural variation in closely related species to unveil the kind of co-evolutionary process in natural populations. Our combination of various powerful approaches in a tractable model system should provide insight on diversification, a poorly understood but fundamental evolutionary process that is taking place at all levels of organization.


year authors and title journal last update
List of publications.
2017 Pierre Saumitou-Laprade, Philippe Vernet, Xavier Vekemans, Vincent Castric, Gianni Barcaccia, Bouchaïb Khadari, Luciana Baldoni
Controlling for genetic identity of varieties, pollen contamination and stigma receptivity is essential to characterize the self-incompatibility system of Olea europaea L.
published pages: 860-866, ISSN: 1752-4571, DOI: 10.1111/eva.12498
Evolutionary Applications 10/9 2020-04-23
2017 Sier-Ching Chantha, Adam C. Herman, Vincent Castric, Xavier Vekemans, William Marande, Daniel J. Schoen
The unusual S locus of Leavenworthia is composed of two sets of paralogous loci
published pages: 1247-1255, ISSN: 0028-646X, DOI: 10.1111/nph.14764
New Phytologist 216/4 2020-04-23
2017 Takashi Tsuchimatsu, Pauline M. Goubet, Sophie Gallina, Anne-Catherine Holl, Isabelle Fobis-Loisy, Hélène Bergès, William Marande, Elisa Prat, Dazhe Meng, Quan Long, Alexander Platzer, Magnus Nordborg, Xavier Vekemans, Vincent Castric
Patterns of Polymorphism at the Self-Incompatibility Locus in 1,083 Arabidopsis thaliana Genomes
published pages: , ISSN: 0737-4038, DOI: 10.1093/molbev/msx122
Molecular Biology and Evolution 2020-04-23
2017 Polina Yu. Novikova, Takashi Tsuchimatsu, Samson Simon, Viktoria Nizhynska, Viktor Voronin, Robin Burns, Olga M. Fedorenko, Svante Holm, Torbjörn Säll, Elisa Prat, William Marande, Vincent Castric, Magnus Nordborg
Genome sequencing reveals the origin of the allotetraploid Arabidopsis suecica
published pages: msw299, ISSN: 0737-4038, DOI: 10.1093/molbev/msw299
Molecular Biology and Evolution 2020-04-23

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