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StemNicheOnWaveCrest SIGNED

New therapies for myeloproliferative diseases based on multi-stage and -system analyses of the haematopoietic stem-cell niche

Total Cost €

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EC-Contrib. €

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Partnership

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 StemNicheOnWaveCrest project word cloud

Explore the words cloud of the StemNicheOnWaveCrest project. It provides you a very rough idea of what is the project "StemNicheOnWaveCrest" about.

tight    shown    cells    ideal    damage    anticipate    sex    inhibitors    cancer    developmental    mutated    uncovered    microenvironment    clinically    regulated    hormones    circulation    incidence    regulation    cellular    pacemaker    supporting    haematopoietic    previously    immune    stem    adult    blocking    division    suggest    share    therapies    clinical    rescue    potentially    oestrogens    vertebrates    eradicate    nevertheless    hsc    leukaemic    nerves    network    data    neuroendocrine    protection    gender    skeleton    transplantation    hscs    myeloproliferative    nestin    bone    diseases    relationships    incurable    jak    regulatory    fructify    differences    found    saving    manifestation    peripheral    components    form    thought    expansion    glial    approved    contains    niche    instead    maintenance    mscs    neoplasms    treatment    cell    brain    selective    origin    types    life    drugs    mutation    frequent    traffic    generate    survival    progenitor    blood    mesenchymal    marrow    central    normal    contrarily    leukaemia    solely   

Project "StemNicheOnWaveCrest" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙594˙500 €
 EC max contribution 1˙594˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙594˙500.00

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 Project objective

Blood cells are produced in the bone marrow, which contains two distinct adult stem cell types: haematopoietic stem cells (HSCs), that generate all blood and immune cells, and mesenchymal stem cells (MSCs), thought to form the skeleton. HSCs traffic between bone marrow and circulation, what allows for life-saving clinical transplantation. Our previous work has shown that HSC numbers in blood are regulated by the central pacemaker in the brain, which reaches bone marrow nestin MSCs through the nerves. Contrarily to what it was believed, our recent data suggest that HSC-niche MSCs are different from those that form the skeleton and share instead a common origin with peripheral nerves and supporting glial cells. Thus, tight regulation of the bone marrow stem-cell niche in vertebrates might build upon developmental relationships of its cellular components. Moreover, we have shown that damage to this regulatory network is essential for the manifestation of myeloproliferative neoplasms, diseases that were previously thought to be driven solely by mutated HSCs. Also, JAK inhibitors (blocking the most frequent HSC mutation found in myeloproliferative neoplasms) cannot eradicate leukaemia stem cells. Our recent data has uncovered a selective regulation of normal and leukaemic haematopoietic progenitor maintenance, survival and division by sex hormones (oestrogens). These results might explain gender differences in blood cancer incidence and they also offer a new way of targeting leukaemia stem cells with clinically approved drugs. Nevertheless, we anticipate that the ideal future treatment of myeloproliferative diseases should target both leukaemia stem cells and their microenvironment. We have shown that protection or rescue of the niche is able to control the expansion of mutated cells. We aim to study this novel neuroendocrine regulation of bone marrow stem cells that will potentially fructify in new therapies for incurable myeloproliferative diseases.

 Publications

year authors and title journal last update
List of publications.
2020 Simón Méndez-Ferrer, Dominique Bonnet, David P. Steensma, Robert P. Hasserjian, Irene M. Ghobrial, John G. Gribben, Michael Andreeff , Daniela S. Krause
Bone marrow niches in haematological malignancies
published pages: , ISSN: 1474-175X, DOI: 10.1038/s41568-020-0245-2
Nature Reviews Cancer 2020-03-11
2020 Ya-Hsuan Ho, Simón Méndez-Ferrer
Microenvironmental contributions to hematopoietic stem cell aging
published pages: 38-46, ISSN: 0390-6078, DOI: 10.3324/haematol.2018.211334
Haematologica 105/1 2020-03-11
2019 David Ramos, Joana Catita, Mariana López-Luppo, Andreia Valença, Aina Bonet, Ana Carretero, Marc Navarro, Victor Nacher, Simon Mendez-Ferrer, Anna Meseguer, Alba Casellas, Luísa Mendes-Jorge, Jesús Ruberte
Vascular Interstitial Cells in Retinal Arteriolar Annuli Are Altered During Hypertension
published pages: 473, ISSN: 1552-5783, DOI: 10.1167/iovs.18-25000
Investigative Opthalmology & Visual Science 60/2 2020-03-11
2019 Mehmet Saçma, Johannes Pospiech, Ruzhica Bogeska, Walter de Back, Jan-Philipp Mallm, Vadim Sakk, Karin Soller, Gina Marka, Angelika Vollmer, Rebekah Karns, Nina Cabezas-Wallscheid, Andreas Trumpp, Simón Méndez-Ferrer, Michael D. Milsom, Medhanie A. Mulaw, Hartmut Geiger, Maria Carolina Florian
Haematopoietic stem cells in perisinusoidal niches are protected from ageing
published pages: 1309-1320, ISSN: 1465-7392, DOI: 10.1038/s41556-019-0418-y
Nature Cell Biology 21/11 2020-03-11
2018 Karin Golan, Anju Kumari, Orit Kollet, Eman Khatib-Massalha, Mohana Devi Subramaniam, Zulma S. Ferreira, Francesca Avemaria, Sylwia Rzeszotek, Andrés García-García, Stephanie Xie, Eugenia Flores-Figueroa, Shiri Gur-Cohen, Tomer Itkin, Aya Ludin-Tal, Hassan Massalha, Biana Bernshtein, Andrzej K. Ciechanowicz, Alexander Brandis, Tevie Mehlman, Suditi Bhattacharya, Mayla Bertagna, Hui Cheng, Ekate
Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance
published pages: 572-585.e7, ISSN: 1934-5909, DOI: 10.1016/j.stem.2018.08.002
Cell Stem Cell 23/4 2020-03-11
2019 Simón Méndez-Ferrer
Molecular interactome between HSCs and their niches
published pages: 1197-1198, ISSN: 0006-4971, DOI: 10.1182/blood.2019002615
Blood 134/15 2020-03-11
2019 Ya-Hsuan Ho, Raquel del Toro, José Rivera-Torres, Justyna Rak, Claudia Korn, Andrés García-García, David Macías, Cristina González-Gómez, Alberto del Monte, Monika Wittner, Amie K. Waller, Holly R. Foster, Carlos López-Otín, Randall S. Johnson, Claus Nerlov, Cedric Ghevaert, William Vainchenker, Fawzia Louache, Vicente Andrés, Simón Méndez-Ferrer
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging
published pages: 407-418.e6, ISSN: 1934-5909, DOI: 10.1016/j.stem.2019.06.007
Cell Stem Cell 25/3 2020-03-11
2019 Dorian Forte, Daniela S. Krause, Michael Andreeff, Dominique Bonnet, Simón Méndez-Ferrer
Updates on the hematologic tumor microenvironment and its therapeutic targeting
published pages: 1928-1934, ISSN: 0390-6078, DOI: 10.3324/haematol.2018.195396
Haematologica 104/10 2020-03-11
2019 Beatrice Drexler, Jakob R. Passweg, Alexandar Tzankov, Martin Bigler, Alexandre PA Theocharides, Nathan Cantoni, Peter Keller, Georg Stussi, Axel Ruefer, Rudolf Benz, Geneviève Favre, Pontus Lundberg, Ronny Nienhold, Andrea Fuhrer, Christine Biaggi, Markus G. Manz, Mario Bargetzi, Simon Mendez-Ferrer, Radek C. Skoda
The sympathomimetic agonist mirabegron did not lower JAK2 -V617F allele burden, but restored nestin-positive cells and reduced reticulin fibrosis in patients with myeloproliferative neoplasms: results of phase II study SAKK 33/14
published pages: 710-716, ISSN: 0390-6078, DOI: 10.3324/haematol.2018.200014
Haematologica 104/4 2020-03-11
2019 Andrés García-García, Claudia Korn, María García-Fernández, Olivia Domingues, Javier Villadiego, Daniel Martín-Pérez, Joan Isern, José A. Bejarano-García, Jacques Zimmer, José A. Pérez-Simón, Juan J. Toledo-Aral, Tatiana Michel, Matti S. Airaksinen, Simón Méndez-Ferrer
Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes
published pages: 224-236, ISSN: 0006-4971, DOI: 10.1182/blood-2018-08-867648
Blood 133/3 2020-01-15
2017 Anna Merlo, Cristóbal Bernardo-Castiñeira, Inés Sáenz-de-Santa-María, Ana S Pitiot, Milagros Balbín, Aurora Astudillo, Nuria Valdés, Bartolomé Scola, Raquel Del Toro, Simón Méndez-Ferrer, José I Piruat, Carlos Suarez, María-Dolores Chiara
Role of VHL, HIF1A and SDH on the expression of miR-210: Implications for tumoral pseudo-hypoxic fate
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.14265
Oncotarget 8/4 2020-01-15
2017 Abel Sánchez-Aguilera, Simón Méndez-Ferrer
The hematopoietic stem-cell niche in health and leukemia
published pages: 579-590, ISSN: 1420-682X, DOI: 10.1007/s00018-016-2306-y
Cellular and Molecular Life Sciences 74/4 2020-01-15
2016 A. Engert, C. Balduini, A. Brand, B. Coiffier, C. Cordonnier, H. Dohner, T. D. de Wit, S. Eichinger, W. Fibbe, T. Green, F. de Haas, A. Iolascon, T. Jaffredo, F. Rodeghiero, G. Salles, J. J. Schuringa, J. J. Schuringa, T. Jaffredo, B. Coiffier, G. Salles, H. Dohner, A. Iolascon, C. Balduini, S. Eichinger, A. Brand, C. Cordonnier, W. Fibbe
The European Hematology Association Roadmap for European Hematology Research: a consensus document
published pages: 115-208, ISSN: 0390-6078, DOI: 10.3324/haematol.2015.136739
Haematologica 101/2 2020-01-15
2016 Justyna Rak, Simón Méndez-Ferrer
T-ALL: several homes rather than homeless?
published pages: 1-2, ISSN: 0818-9641, DOI: 10.1038/icb.2016.103
Immunology and Cell Biology 95/1 2020-01-15
2018 Maurizio Mangolini, Frederik Götte, Andrew Moore, Tim Ammon, Madlen Oelsner, Gloria Lutzny-Geier, Ludger Klein-Hitpass, James C. Williamson, Paul J. Lehner, Jan Dürig, Michael Möllmann, Lívia Rásó-Barnett, Katherine Hughes, Antonella Santoro, Simón Méndez-Ferrer, Robert A. J. Oostendorp, Ursula Zimber-Strobl, Christian Peschel, Daniel J. Hodson, Marc Schmidt-Supprian, Ingo Ringshausen
Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06069-5
Nature Communications 9/1 2020-01-15
2017 Simón Méndez-Ferrer
Human and mouse leukocytes: different clockwork
published pages: 1960-1961, ISSN: 0006-4971, DOI: 10.1182/blood-2017-09-805374
Blood 130/18 2020-01-15
2017 Claudia Korn, Simón Méndez-Ferrer
Myeloid malignancies and the microenvironment
published pages: 811-822, ISSN: 0006-4971, DOI: 10.1182/blood-2016-09-670224
Blood 129/7 2020-01-15
2016 María García-Fernández, Simón Méndez-Ferrer
Under Pressure: When a Transformed Environment Pushes Cells to Malignancy
published pages: 559-560, ISSN: 1934-5909, DOI: 10.1016/j.stem.2016.10.012
Cell Stem Cell 19/5 2020-01-15
2016 Raquel del Toro, Raphael Chèvre, Cristina Rodríguez, Antonio Ordóñez, José Martínez-González, Vicente Andrés, Simón Méndez-Ferrer
Nestin+ cells direct inflammatory cell migration in atherosclerosis
published pages: 12706, ISSN: 2041-1723, DOI: 10.1038/ncomms12706
Nature Communications 7 2020-01-15

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