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ObesityDevelop SIGNED

Effects of maternal gestational adiposity on fetal development and perinatal, postnatal and next generation health.

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ObesityDevelop" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙863˙321 €
 EC max contribution 1˙863˙321 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 1˙863˙321.00

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 Project objective

Pregnant women who are overweight/obese have increased risks of adverse perinatal outcomes, and of having offspring who are subsequently overweight/obese. A potentially important consequence of this is that it will drive the obesity epidemic across generations. Evidence from animal models supports this, but it has not been explored in humans. Furthermore, we need to know the mechanisms linking maternal adiposity to adverse offspring and next generation outcomes in order to develop preventive interventions. I will use data from up to 100,000 participants from nine cohorts and two consortia to determine the effects of maternal pregnancy levels of adiposity and associated circulating nutrients on levels of adiposity and cardiometabolic health at three periods of the lifecourse: (i) fetal development, (ii) infancy to adulthood and (iii) in the next generation. My team is world leading in this area, and we will use state-of-the-art methods to advance the field by: (i) assessing a larger number of maternal nutrients than previously; (ii) accurately assessing maternal gestational fat deposition; (iii) determining the effects of maternal exposures on fetal fat and lean mass, and metabolic response; and (iv) measuring outcomes into the next generation. Effects will be replicated in several independent cohorts and triangulated across different state-of-the-art statistical methods: (i) cross-cohort comparisons between European and low and middle income country cohorts, in which confounding structures differ; (ii) comparisons of associations of maternal exposures to equivalent associations of paternal exposures, under the assumption that intrauterine effects are maternal specific; and (iii) Mendelian randomization using genetic variants as unconfounded proxies for maternal exposures. My proposed research is important because of how many women start pregnancy overweight/obese. It will provide a step-change in knowledge of how to prevent adverse outcomes across generations.

 Publications

year authors and title journal last update
List of publications.
2016 Neil Pearce, Debbie A Lawlor
Causal inference—so much more than statistics
published pages: 1895-1903, ISSN: 0300-5771, DOI: 10.1093/ije/dyw328
International Journal of Epidemiology 45/6 2019-10-08
2018 Judith S. Brand, Jane West, Derek Tuffnell, Philippa K. Bird, John Wright, Kate Tilling, Debbie A. Lawlor
Gestational diabetes and ultrasound-assessed fetal growth in South Asian and White European women: findings from a prospective pregnancy cohort
published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-018-1191-7
BMC Medicine 16/1 2019-10-08
2019 Philippa K Bird, Rosemary R. C. McEachan, Mark Mon-Williams, Neil Small, Jane West, Peter Whincup, John Wright, Elizabeth Andrews, Sally E Barber, Liam J B Hill, Laura Lennon, Dan Mason, Katy A Shire, Dagmar Waiblinger, Amanda H. Waterman, Deborah A. Lawlor, Kate E. Pickett
Growing up in Bradford: protocol for the age 7–11 follow up of the Born in Bradford birth cohort
published pages: , ISSN: 1471-2458, DOI: 10.1186/s12889-019-7222-2
BMC Public Health 19/1 2019-09-20
2019 Christel M. Middeldorp, Janine F. Felix, Anubha Mahajan, Mark I. McCarthy
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
published pages: 279-300, ISSN: 0393-2990, DOI: 10.1007/s10654-019-00502-9
European Journal of Epidemiology 34/3 2019-09-20
2017 Ralph McGinnis, Valgerdur Steinthorsdottir, Nicholas O Williams, Gudmar Thorleifsson, Scott Shooter, Sigrun Hjartardottir, Suzannah Bumpstead, Lilja Stefansdottir, Lucy Hildyard, Jon K Sigurdsson, John P Kemp, Gabriela B Silva, Liv Cecilie V Thomsen, Tiina Jääskeläinen, Eero Kajantie, Sally Chappell, Noor Kalsheker, Ashley Moffett, Susan Hiby, Wai Kwong Lee, Sandosh Padmanabhan, Nigel A B Simps
Variants in the fetal genome near FLT1 are associated with risk of preeclampsia
published pages: 1255-1260, ISSN: 1061-4036, DOI: 10.1038/ng.3895
Nature Genetics 49/8 2019-07-04
2017 N Patel, K M Godfrey, D Pasupathy, J Levin, A C Flynn, L Hayes, A L Briley, R Bell, D A Lawlor, E Oteng-Ntim, S M Nelson, S C Robson, N Sattar, C Singh, J Wardle, S L White, P T Seed, L Poston
Infant adiposity following a randomised controlled trial of a behavioural intervention in obese pregnancy
published pages: , ISSN: 0307-0565, DOI: 10.1038/ijo.2017.44
International Journal of Obesity 2019-07-04
2018 Robin N Beaumont, Nicole M Warrington, Alana Cavadino, Jessica Tyrrell, Michael Nodzenski, Momoko Horikoshi, Frank Geller, Ronny Myhre, Rebecca C Richmond, Lavinia Paternoster, Jonathan P Bradfield, Eskil Kreiner-Møller, Ville Huikari, Sarah Metrustry, Kathryn L Lunetta, Jodie N Painter, Jouke-Jan Hottenga, Catherine Allard, Sheila J Barton, Ana Espinosa, Julie A Marsh, Catherine Potter, Ge Zhang
Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics
published pages: 742-756, ISSN: 0964-6906, DOI: 10.1093/hmg/ddx429
Human Molecular Genetics 27/4 2019-07-04
2017 N M Warrington, R Richmond, B Fenstra, R Myhre, R Gaillard, L Paternoster, C A Wang, R N Beaumont, S Das, M Murcia, S J Barton, A Espinosa, E Thiering, M Atalay, N Pitkänen, I Ntalla, A E Jonsson, R Freathy, V Karhunen, C M T Tiesler, C Allard, A Crawford, S M Ring, M Melbye, P Magnus, F Rivadeneira, L Skotte, T Hansen, J Marsh, M Guxens, J W Holloway, H Grallert, V W V Jaddoe, W L Lowe Jr, T Rou
Maternal and fetal genetic contribution to gestational weight gain
published pages: 775-784, ISSN: 0307-0565, DOI: 10.1038/ijo.2017.248
International Journal of Obesity 42/4 2019-07-04
2017 Debbie A. Lawlor, Kate Tilling, George Davey Smith
Triangulation in aetiological epidemiology
published pages: dyw314, ISSN: 0300-5771, DOI: 10.1093/ije/dyw314
International Journal of Epidemiology 2019-07-04
2016 Jessica Tyrrell, Rebecca C. Richmond, Tom M. Palmer, Bjarke Feenstra, Janani Rangarajan, Sarah Metrustry, Alana Cavadino, Lavinia Paternoster, Loren L. Armstrong, N. Maneka G. De Silva, Andrew R. Wood, Momoko Horikoshi, Frank Geller, Ronny Myhre, Jonathan P. Bradfield, Eskil Kreiner-Møller, Ville Huikari, Jodie N. Painter, Jouke-Jan Hottenga, Catherine Allard, Diane J. Berry, Luigi Bouchard, Shik
Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight
published pages: 1129, ISSN: 0098-7484, DOI: 10.1001/jama.2016.1975
JAMA 315/11 2019-07-04
2016 Qin Wang, Peter Würtz, Kirsi Auro, Laure Morin-Papunen, Antti J Kangas, Pasi Soininen, Mika Tiainen, Tuulia Tynkkynen, Anni Joensuu, Aki S Havulinna, Kristiina Aalto, Marko Salmi, Stefan Blankenberg, Tanja Zeller, Jorma Viikari, Mika Kähönen, Terho Lehtimäki, Veikko Salomaa, Sirpa Jalkanen, Marjo-Riitta Järvelin, Markus Perola, Olli T Raitakari, Debbie A Lawlor, Johannes Kettunen, Mika Ala-Ko
Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence
published pages: 1445-1457, ISSN: 0300-5771, DOI: 10.1093/ije/dyw147
International Journal of Epidemiology 45/5 2019-07-04
2013 Deborah Lawlor, Rebecca Richmond, Nicole Warrington, George McMahon, George Davey Smith, Jack Bowden, David M Evans
Using Mendelian randomization to determine causal effects of maternal pregnancy (intrauterine) exposures on offspring outcomes: Sources of bias and methods for assessing them
published pages: 11, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.10567.1
Wellcome Open Research 2 2019-07-04
2016 Wang Q, Würtz P, Auro K, Kangas AJ, Soininen P, Tiainen M, Tynkkynen T, Jokelainen J, Santalahti K, Salmi M, Blankenberg S, Zeller T, Viikari J, Kähönen M, Lehtimäki T, Salomaa V, Perola M, Jalkanen S, Järvelin M-R, Raitakari OT, Kettunen J, Lawlor DA*, Ala-Korpela M* (*equal senior authors)
Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence
published pages: 205, ISSN: 1741-7015, DOI: 10.1186/s12916-016-0733-0
BMC Medicine 2016 2019-07-04
2016 Peter Würtz, Qin Wang, Marjo Niironen, Tuulia Tynkkynen, Mika Tiainen, Fotios Drenos, Antti J Kangas, Pasi Soininen, Michael R Skilton, Kauko Heikkilä, Anneli Pouta, Mika Kähönen, Terho Lehtimäki, Richard J Rose, Eero Kajantie, Markus Perola, Jaakko Kaprio, Johan G Eriksson, Olli T Raitakari, Debbie A Lawlor, George Davey Smith, Marjo-Riitta Järvelin, Mika Ala-Korpela, Kirsi Auro
Metabolic signatures of birthweight in 18 288 adolescents and adults
published pages: 1539-1550, ISSN: 0300-5771, DOI: 10.1093/ije/dyw255
International Journal of Epidemiology 45/5 2019-07-04
2017 Diana L. Santos Ferreira, Dylan M. Williams, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, George Davey Smith, Marjo-Riitta Jarvelin, Debbie A. Lawlor
Association of pre-pregnancy body mass index with offspring metabolic profile: Analyses of 3 European prospective birth cohorts
published pages: e1002376, ISSN: 1549-1676, DOI: 10.1371/journal.pmed.1002376
PLOS Medicine 14/8 2019-07-04
2017 Matias C. Vieira, Sara L. White, Nashita Patel, Paul T. Seed, Annette L. Briley, Jane Sandall, Paul Welsh, Naveed Sattar, Scott M. Nelson, Debbie A. Lawlor, Lucilla Poston, Dharmintra Pasupathy
Prediction of uncomplicated pregnancies in obese women: a prospective multicentre study
published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-017-0956-8
BMC Medicine 15/1 2019-07-04
2017 Richmond RC, Timpson NJ, Felix JF, Palmer T, Gaillard R, McMahon G, Davey Smith G, Jaddoe VW, Lawlor DA
Using genetic variation to explore the causal effect of maternal pregnancy adiposity on future offspring adiposity
published pages: e1002221, ISSN: 1549-1277, DOI: 10.1371/journal.pmed.1002221
PloS Medicine 2017 2019-07-04
2018 Jane West, Gillian Santorelli, Peter H. Whincup, Lesley Smith, Naveed A. Sattar, Noel Cameron, Diane Farrar, Paul Collings, John Wright, Debbie A. Lawlor
Association of maternal exposures with adiposity at age 4/5 years in white British and Pakistani children: findings from the Born in Bradford study
published pages: 242-252, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4457-2
Diabetologia 61/1 2019-07-04
2016 Diane Farrar, Mark Simmonds, Maria Bryant, Trevor A Sheldon, Derek Tuffnell, Su Golder, Fidelma Dunne, Debbie A Lawlor
Hyperglycaemia and risk of adverse perinatal outcomes: systematic review and meta-analysis
published pages: i4694, ISSN: 1756-1833, DOI: 10.1136/bmj.i4694
BMJ 2019-07-04

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