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NISCI SIGNED

Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NISCI project word cloud

Explore the words cloud of the NISCI project. It provides you a very rough idea of what is the project "NISCI" about.

individual    sprouting    nerve    severe    social    disorder    acute    tetraplegic    people    fiber    fluid    animal    spinal    traumatic    shown    quality    axonal    injury    breakthrough    proof    protein    blind    efficacy    incomplete    fibers    broad    serum    newly    prediction    complete    cerebro    regenerate    enrollment    suffering    almost    200    cord    permanent    inhibitory    antibody    injured    tolerated    clinical    eventual    double    leaves    brain    scrutinizing    outcomes    motor    normal    patient    damaged    reveal    models    effectiveness    body    succeeded    safe    regeneration    treatment    neuroplasticity    devastating    warrant    outcome    trial    multiple    living    neurological    unprecedented    patients    positive    incidence    paralysis    enormous    expectancy    sclerosis    intrathecal    stroke    nogo    markers    interrupted    life    enroll    population    preclinical    translation    algorithms    surrogate    degrees    therapy    drug    injuries    advancements    neuroimaging    placebo    repair   

Project "NISCI" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT ZURICH 

Organization address
address: RAMISTRASSE 71
city: ZURICH
postcode: 8006
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website http://www.nisi-2020.eu
 Total cost 6˙702˙978 €
 EC max contribution 4˙774˙444 € (71%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2015-single-stage_RTD
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT ZURICH CH (ZURICH) coordinator 75˙000.00
2    UNIVERSITATSKLINIKUM HEIDELBERG DE (HEIDELBERG) participant 2˙037˙290.00
3    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 768˙647.00
4    RUHR-UNIVERSITAET BOCHUM DE (BOCHUM) participant 295˙000.00
5    BG KLINIKUM MURNAU GGMBH DE (MURNAU A.STAFFELSEE) participant 281˙848.00
6    KLINIKUM BAYREUTH GMBH DE (BAYREUTH) participant 281˙848.00
7    TP21 GMBH DE (BERLIN) participant 278˙125.00
8    ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK FR (PARIS) participant 272˙836.00
9    FONDAZIONE SANTA LUCIA IT (Roma) participant 166˙413.00
10    FAKULTNI NEMOCNICE V MOTOLE CZ (PRAHA 5) participant 158˙717.00
11    FUNDACIO INSTITUT GUTTMANN ES (BADALONA) participant 158˙717.00

Map

 Project objective

Spinal cord injury is a severe and devastating neurological disorder that leaves patients with permanent paralysis of the body. No treatment is available today to regenerate interrupted nerve fibers and repair the damaged spinal cord. The incidence of spinal cord injury is about newly injured 10’000 people per year in the EU, and due to an almost normal life expectancy more than 200’000 patients are living with a spinal cord injury in the EU. The impact on the individual quality of life is high, and social costs are enormous. Recent preclinical research in animal models succeeded to greatly enhance axonal sprouting, fiber regeneration and neuroplasticity following injuries of brain and spinal cord. These results warrant translation now to patients suffering from acute spinal cord injury. A previous phase I clinical study using intrathecal application of a nerve fiber growth promoting antibody against the growth inhibitory protein Nogo-A has shown in patients with complete spinal cord injury that this treatment is safe and well tolerated. The present study will enroll patients with various degrees of complete to incomplete acute spinal cord injury for a double-blind, placebo-controlled trial to test the efficacy of this antibody therapy to improve motor outcome and quality of life of tetraplegic patients. The enrollment of patients with different degrees of spinal cord injury is considered essential to reveal drug activity and eventual proof of concept in a broad patient population. Advancements in clinical trial design, improved prediction algorithms of clinical outcomes and development of surrogate markers (in cerebro-spinal fluid/serum and by neuroimaging) will allow for scrutinizing the effectiveness of this novel treatment in an unprecedented way. A positive outcome of this trial will represent a breakthrough for the future therapy of spinal cord injuries and beyond (traumatic brain injury, stroke, multiple sclerosis).

 Publications

year authors and title journal last update
List of publications.
2017 K. Barkovits, A. Linden, S. Galozzi, J. Uszkoreit, B. Mollenhauer, K. Marcus
Characterization of cerebrospinal fluid via data-independent acquisition mass spectrometry
published pages: 1 (Poster), ISSN: , DOI:
Proteomic Forum 2017 Annual meeting of the German Society for Proteome Research 2–5 April 2017 2020-03-20
2017 Georgia Minakaki, Stefanie Menges, Agnes Kittel, Evangelia Emmanouilidou, Iris Schaeffner, Katalin Barkovits, Anna Bergmann, Edward Rockenstein, Anthony Adame, Franz Marxreiter, Brit Mollenhauer, Douglas Galasko, Edit Irén Buzás, Ursula Schlötzer-Schrehardt, Katrin Marcus, Wei Xiang, Dieter Chichung Lie, Kostas Vekrellis, Eliezer Masliah, Jürgen Winkler, Jochen Klucken
Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype
published pages: 98-119, ISSN: 1554-8627, DOI: 10.1080/15548627.2017.1395992
Autophagy 14/1 2020-03-20
2018 Eveline Huber, Gergely David, Alan J. Thompson, Nikolaus Weiskopf, Siawoosh Mohammadi, Patrick Freund
Dorsal and ventral horn atrophy is associated with clinical outcome after spinal cord injury
published pages: e1510-e1522, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000005361
Neurology 90/17 2020-03-20
2018 Gabriel Ziegler, Patrick Grabher, Alan Thompson, Daniel Altmann, Markus Hupp, John Ashburner, Karl Friston, Nikolaus Weiskopf, Armin Curt, Patrick Freund
Progressive neurodegeneration following spinal cord injury
published pages: e1257-e1266, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000005258
Neurology 90/14 2020-03-20
2018 Luke J. Edwards, Evgeniya Kirilina, Siawoosh Mohammadi, Nikolaus Weiskopf
Microstructural imaging of human neocortex in vivo
published pages: 184-206, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2018.02.055
NeuroImage 182 2020-03-20
2018 Lukas M. Schilde, Steffen Kösters, Simone Steinbach, Karin Schork, Martin Eisenacher, Sara Galozzi, Michael Turewicz, Katalin Barkovits, Brit Mollenhauer, Katrin Marcus, Caroline May
Protein variability in cerebrospinal fluid and its possible implications for neurological protein biomarker research
published pages: e0206478, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0206478
PLOS ONE 13/11 2020-03-20
2018 Maryam Seif, Armin Curt, Alan J. Thompson, Patrick Grabher, Nikolaus Weiskopf, Patrick Freund
Quantitative MRI of rostral spinal cord and brain regions is predictive of functional recovery in acute spinal cord injury
published pages: 556-563, ISSN: 2213-1582, DOI: 10.1016/j.nicl.2018.08.026
NeuroImage: Clinical 20 2020-03-20
2019 Sara Lorio, Tim M. Tierney, Amy McDowell, Owen J. Arthurs, Antoine Lutti, Nikolaus Weiskopf, David W. Carmichael
Flexible proton density (PD) mapping using multi-contrast variable flip angle (VFA) data
published pages: 464-475, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2018.11.023
NeuroImage 186 2020-03-20
2017 S. Mohammadi, N. Weiskopf
Computationale Neuroanatomie und Mikrostrukturbildgebung mit der Magnetresonanztomographie
published pages: 839-849, ISSN: 0028-2804, DOI: 10.1007/s00115-017-0373-4
Der Nervenarzt 88/8 2020-03-20
2017 Robert Trampel, Pierre-Louis Bazin, Kerrin Pine, Nikolaus Weiskopf
In-vivo magnetic resonance imaging (MRI) of laminae in the human cortex
published pages: , ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.09.037
NeuroImage 2020-03-20
2018 Balteau, E.; Tabelow, K.; Ashburner, J.; Callaghan, M.; Draganski, B.; Helms, G.; Kherif, F.; Leutritz, T.; Lutti, A.; Philips, C.; Reimer, E.; Ruthotto, L.; Seif, M.; Weiskopf, N.; Ziegler, G.; Mohammadi, S.
hMRI: A toolbox for using quantitative MRI in neuroscience and clinical research
published pages: , ISSN: 2198-5855, DOI: 10.20347/WIAS.PREPRINT.2527
WIAS Preprint 1 2020-03-20
2016 Patrick Freund, Karl Friston, Alan J. Thompson, Klaas E. Stephan, John Ashburner, Dominik R. Bach, Zoltan Nagy, Gunther Helms, Bogdan Draganski, Siawoosh Mohammadi, Martin E. Schwab, Armin Curt, Nikolaus Weiskopf
Embodied neurology: an integrative framework for neurological disorders
published pages: 1855-1861, ISSN: 0006-8950, DOI: 10.1093/brain/aww076
Brain 139/6 2020-03-20
2017 Prados, Ferran; Ashburner, John; Blaiotta, Claudia; Brosch, Tom; Carballido-Gamio, Julio; Cardoso, Manuel Jorge; Conrad, Benjamin N.; Datta, Esha; Dávid, Gergely; Leener, Benjamin de; Dupont, Sara M.; Freund, Patrick; Wheeler-Kingshott, Claudia A.M.Gandini; Grussu, Francesco; Henry, Roland; Landman, Bennett A.; Ljungberg, Emil; Lyttle, Bailey; Ourselin, Sebastien; Papinutto, Nico; Saporito, Salvatore; Schlaeger, Regina; Smith, Seth A.; Summers, Paul; Tam, Roger; Yiannakas, Marios C.; Zhu, Alyssa; Cohen-Adad, Julien
Spinal cord grey matter segmentation challenge
published pages: , ISSN: 0346-251X, DOI: 10.5167/uzh-136397
Neuroimage, 152, 312 - 329 1 2020-03-20
2017 Eveline Huber, Patrice Lachappelle, Reto Sutter, Armin Curt, Patrick Freund
Are midsagittal tissue bridges predictive of outcome after cervical spinal cord injury?
published pages: 740-748, ISSN: 0364-5134, DOI: 10.1002/ana.24932
Annals of Neurology 81/5 2020-03-20
2018 Philips, C., Balteau, E., Leutritz, T., Lutti, A., Callaghan, M. F., Draganski, B., Reimer, E., Ruthotto, L., Seif, M., Weiskopf, N., Ziegler, G., Mohammadi, S., Tabelow, K.
The “hMRI Toolbox” for quantitative imaging & in vivo histology using MRI (poster)
published pages: , ISSN: , DOI:
2020-03-20
2018 Balteau, E., Leutritz, T., Weiskopf, N., Reimer, E., Lutti, A., Callaghan, M. F., Mohammadi, S., Tabelow, K.
Evaluating T2* bias impact and correction strategies in quantitative proton density mapping (poster)
published pages: , ISSN: , DOI:
2020-03-20
2018 Seif, M., Leutritz, T., Samson, R. S., Curt, A., Wheeler-Kingshott, C. A. G., Freund, P., Weiskopf, N.
A multi-center study on fast full-brain quantitative multi-parameter mapping of R1, MT, and R2*: Scan-rescan repeatability and inter-site reproducibility (talk)
published pages: , ISSN: , DOI:
2020-03-20
2018 Balteau, E., Leutritz, T., Lutti, A., Callaghan, M. F., Draganski, B., Philips, C., Reimer, E., Ruthotto, L., Seif, M., Weiskopf, N., Ziegler, G., Mohammadi, S., Tabelow, K.
The hMRI analysis toolbox for quantitative MRI and in vivo histology using MRI (hMRI) (poster)
published pages: , ISSN: , DOI:
2020-03-20

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