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WIDENLIFE

Widening the Scientific Excellence for Studies on Women’s and Fetal Health and Wellbeing

Total Cost €

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EC-Contrib. €

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Partnership

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 WIDENLIFE project word cloud

Explore the words cloud of the WIDENLIFE project. It provides you a very rough idea of what is the project "WIDENLIFE" about.

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Project "WIDENLIFE" data sheet

The following table provides information about the project.

Coordinator
TARTU ULIKOOL 

Organization address
address: ULIKOOLI 18
city: TARTU
postcode: 51005
website: www.ut.ee

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Estonia [EE]
 Project website https://sisu.ut.ee/widenlife
 Total cost 1˙064˙607 €
 EC max contribution 1˙064˙607 € (100%)
 Programme 1. H2020-EU.4.b. (Twinning of research institutions)
 Code Call H2020-TWINN-2015
 Funding Scheme CSA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TARTU ULIKOOL EE (TARTU) coordinator 455˙380.00
2    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 357˙252.00
3    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 251˙975.00

Map

 Project objective

Given that one in six couples face infertility, often caused by female factors, women’s reproductive health is a significant medical and socio-economical challenge. Herein, while addressing this issue, the Estonian research on female reproductive health and medicine has rapidly developed with the lead of University of Tartu (UT). Nevertheless, the UT’s capacity and expertise still falls short of the leading institutions. At the same time, also the most competitive research groups face significant barriers to perform world-class science due to substantial networking gaps that still exist between previously non-linked research teams. TWINNING funding scheme is designed to overcome these aforementioned shortcomings. Thus UT has formed a WIDENLIFE consortium with its world-renowned partners: University of Oxford and Katholieke Universiteit Leuven, and altogether we have set two ambitious objectives to address. Firstly, for the UT: to become one of the leading research and teaching centres for reproductive and fetal medicine in Eastern and Northern Europe. Secondly, for all members of consortia: to intensify trilateral synergies between the research groups in the areas of female reproductive health and medicine. Our specific goals are to highlight the associations between female metabolic health and infertility, provide deeper understating for embryonal development, and offer new tools for infertility treatment and prenatal diagnostics. In order to resolve these objectives, exchange of know-how, ideas and information between the partners will be enhanced, creating the novel clinically valuable information through pooling the expertise and synergy of resources, interests and commitments by universities from Estonia, UK and Belgium. This could also mean a significant contribution to the scientific capacity of the Estonian research community as well as the health technology industry, which is one of the main focus areas for Estonian Smart Specialisation Strategy.

 Deliverables

List of deliverables.
Test for non-invasive identification of endometriosis, which has been validated in partner organisations Demonstrators, pilots, prototypes 2019-10-28 17:20:38
Report 3 on dissemination performed as part of local events for the scientific and local communities Documents, reports 2019-10-28 17:20:39
Report on utilizing the UTARTU’s endometrial biopsies for practical training (1) Documents, reports 2019-10-28 17:20:39
Report on cross-applying opportunities for EGCUT and WTCCC datasets Documents, reports 2019-10-28 17:20:39
Report on on-site and off-site trainings performed between UTARTU and UOXF to transfer knowledge on female metabolic health as a predictor of fertility Documents, reports 2019-10-28 17:20:38
Report on off-site virtual trainings and consultations performed to apply the NIPT methods within clinical use at UTARTU (3) Documents, reports 2019-10-28 17:20:38
Senior staff exchanges completed between UTARTU and KU LEUVEN to transfer knowledge for isolating and amplifying DNA and RNA from single blastomere cells and to deploy time-lapse and NIPT methods Documents, reports 2019-10-28 17:20:39
Biobank samples shared for learning purposes (5) Documents, reports 2019-10-28 17:20:39
Report 2 on dissemination performed as part of local events for the scientific and local communities Documents, reports 2019-10-28 17:20:39
Report 2 on dissemination performed as part of international conferences Documents, reports 2019-10-28 17:20:39
NIPT technology adopted in an initial format by UTARTU’s scientists Demonstrators, pilots, prototypes 2019-10-28 17:20:39
Co-authored article on human preimplantation embryos as a result of PhD students’ short-term stay in KU LEUVEN (2) Documents, reports 2019-10-28 17:20:38
Report on utilizing the UTARTU’s endometrial biopsies for practical training (2) Documents, reports 2019-10-28 17:20:39
Biobank samples shared for learning purposes (4) Documents, reports 2019-10-28 17:20:38
Second workshop held on “female reproduction: ovulatory disorders” Documents, reports 2019-10-28 17:20:39
Report on on-site and off-site trainings performed between UTARTU and UOXF to transfer knowledge for analysing female reproductive ageing Documents, reports 2019-10-28 17:20:38
Co-authored article on female metabolic health as a predictor of fertility as a result of a post-doc’s short-term stay in UOXF (2) Documents, reports 2019-10-28 17:20:38
Joint article written on human preimplantation embryos Documents, reports 2019-10-28 17:20:39
Co-authored article on female reproductive ageing as a result of a PhD students’ short-term stay in UOXF (2) Documents, reports 2019-10-28 17:20:39
Co-authored article on female reproductive ageing as a result of a post-doc’s short-term stay in UOXF Documents, reports 2019-10-28 17:20:38
Joint article written on fetal non-invasive genetic testing Documents, reports 2019-10-28 17:20:38
Clinical use of NIPT technology Demonstrators, pilots, prototypes 2019-10-28 17:20:38
Co-authored article on analysing and implementing fetal non-invasive genetic testing as a result of a PhD student’s short-term stay in KU LEUVEN Documents, reports 2019-10-28 17:20:38
Summer school held in Tartu, Estonia Documents, reports 2019-10-28 17:20:39
Report 3 on dissemination performed as part of international conferences Documents, reports 2019-10-28 17:20:38
Co-authored article on endometrial receptivity, implantation and endometriosis as a result of a PhD student’s short-term stay in UOXF Documents, reports 2019-10-28 17:20:38
Joint article written on female reproductive ageing Documents, reports 2019-10-28 17:20:38
Co-authored article on female reproductive ageing as a result of a PhD students’ short-term stay in UOXF (1) Documents, reports 2019-10-28 17:20:39
Report on off-site virtual trainings and consultations performed to apply the NIPT methods within clinical use at UTARTU (2) Documents, reports 2019-10-28 17:20:38
Joint article written on endometrial receptivity, implantation and endometriosis Documents, reports 2019-10-28 17:20:38
Clinical use of PGS in Tartu University Hospital Demonstrators, pilots, prototypes 2019-10-28 17:20:38
Joint article written on female metabolic health as a predictor of fertility Documents, reports 2019-10-28 17:20:38
Co-authored article on human preimplantation embryos as a result of PhD students’ short-term stay in KU LEUVEN (1) Documents, reports 2019-10-28 17:20:38
Report 1 on dissemination performed as part of international conferences Documents, reports 2019-10-28 17:20:38
Biobank samples shared for learning purposes (3) Documents, reports 2019-10-28 17:20:38
First workshop held on “female reproduction: ovulatory disorders” Documents, reports 2019-10-28 17:20:38
Report on off-site virtual trainings and consultations performed to apply the NIPT methods within clinical use at UTARTU (1) Documents, reports 2019-10-28 17:20:38
Co-authored article on analysing and implementing fetal non-invasive genetic testing as a result of a post-doc’s short-term stay in KU LEUVEN Documents, reports 2019-10-28 17:20:38
Report 1 on dissemination performed as part of local events for the scientific and local communities Documents, reports 2019-10-28 17:20:38
Workshop held on single cell genomics Documents, reports 2019-10-28 17:20:38
Biobank samples shared for learning purposes (2) Documents, reports 2019-10-28 17:20:38
Biobank samples shared for learning purposes (1) Documents, reports 2019-10-28 17:20:38
Co-authored article on female metabolic health as a predictor of fertility as a result of a PhD student’s short-term stay in UOXF (1) Documents, reports 2019-10-28 17:20:38

Take a look to the deliverables list in detail:  detailed list of WIDENLIFE deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Dmitry Shungin, Wei Q. Deng, Tibor V. Varga, Jian\'an Luan, Evelin Mihailov, Andres Metspalu, Andrew P. Morris, Nita G. Forouhi, Cecilia Lindgren, Patrik K. E. Magnusson, Nancy L. Pedersen, Göran Hallmans, Audrey Y. Chu, Anne E. Justice, Mariaelisa Graff, Thomas W. Winkler, Lynda M. Rose, Claudia Langenberg, L. Adrienne Cupples, Paul M. Ridker, Nicholas J. Wareham, Ken K. Ong, Ruth J. F. Loos, Daniel I. Chasman, Erik Ingelsson, Tuomas O. Kilpeläinen, Robert A. Scott, Reedik Mägi, Guillaume Paré, Paul W. Franks
Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions
published pages: e1006812, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1006812
PLOS Genetics 13/6 2019-10-28
2016 O. Tšuiko, M. Nõukas, O. Žilina, K. Hensen, J.S. Tapanainen, R. Mägi, M. Kals, P.A. Kivistik, K. Haller-Kikkatalo, A. Salumets, A. Kurg
Copy number variation analysis detects novel candidate genes involved in follicular growth and oocyte maturation in a cohort of premature ovarian failure cases
published pages: 1913-1925, ISSN: 0268-1161, DOI: 10.1093/humrep/dew142
Human Reproduction 31/8 2019-10-28
2016 Gerly Sillaste, Lauris Kaplinski, Riho Meier, Ãœlle Jaakma, Elo Eriste, Andres Salumets
A novel hypothesis for histone-to-protamine transition in Bos taurus spermatozoa
published pages: 241-251, ISSN: 1470-1626, DOI: 10.1530/REP-16-0441
Reproduction 153/3 2019-10-28
2017 Olga Mazina, Anni Allikalt, Juha S. Tapanainen, Andres Salumets, Ago Rinken
Determination of biological activity of gonadotropins hCG and FSH by Förster resonance energy transfer based biosensors
published pages: 42219, ISSN: 2045-2322, DOI: 10.1038/srep42219
Scientific Reports 7 2019-10-28
2017 Kadri Haller-Kikkatalo, Kristi Alnek, Andres Metspalu, Evelin Mihailov, Kaja Metsküla, Kalle Kisand, Heti Pisarev, Andres Salumets, Raivo Uibo
Demographic associations for autoantibodies in disease-free individuals of a European population
published pages: 44846, ISSN: 2045-2322, DOI: 10.1038/srep44846
Scientific Reports 7 2019-10-28
2016 Nageswara Rao Boggavarapu, Sujata Lalitkumar, Vijay Joshua, Sergo Kasvandik, Andres Salumets, Parameswaran Grace Lalitkumar, Kristina Gemzell-Danielsson
Compartmentalized gene expression profiling of receptive endometrium reveals progesterone regulated ENPP3 is differentially expressed and secreted in glycosylated form
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep33811
Scientific Reports 6/1 2019-10-28
2016 Airi Tiirats, Triin Viltrop, Margit Nõukas, Ene Reimann, Andres Salumets, Sulev Kõks
C14orf132 gene is possibly related to extremely low birth weight
published pages: , ISSN: 1471-2156, DOI: 10.1186/s12863-016-0439-5
BMC Genetics 17/1 2019-10-28
2016 Triin Laisk-Podar, Cecilia M. Lindgren, Maire Peters, Juha S. Tapanainen, Cornelis B. Lambalk, Andres Salumets, Reedik Mägi
Ovarian Physiology and GWAS: Biobanks, Biology, and Beyond
published pages: 516-528, ISSN: 1043-2760, DOI: 10.1016/j.tem.2016.04.011
Trends in Endocrinology & Metabolism 27/7 2019-10-28
2016 Lusine Aghajanova, Signe Altmäe, Sergo Kasvandik, Andres Salumets, Anneli Stavreus-Evers, Linda C. Giudice
Stanniocalcin-1 expression in normal human endometrium and dysregulation in endometriosis
published pages: 681-691.e1, ISSN: 0015-0282, DOI: 10.1016/j.fertnstert.2016.05.023
Fertility and Sterility 106/3 2019-10-28
2016 Natalia Pervjakova, Silva Kasela, Andrew P Morris, Mart Kals, Andres Metspalu, Cecilia M Lindgren, Andres Salumets, Reedik Mägi
Imprinted genes and imprinting control regions show predominant intermediate methylation in adult somatic tissues
published pages: 789-799, ISSN: 1750-1911, DOI: 10.2217/epi.16.8
Epigenomics 8/6 2019-10-28
2016 Merli Saare, Vijayachitra Modhukur, Marina Suhorutshenko, Balaji Rajashekar, Kadri Rekker, Deniss Sõritsa, Helle Karro, Pille Soplepmann, Andrei Sõritsa, Cecilia M. Lindgren, Nilufer Rahmioglu, Alexander Drong, Christian M. Becker, Krina T. Zondervan, Andres Salumets, Maire Peters
The influence of menstrual cycle and endometriosis on endometrial methylome
published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-015-0168-z
Clinical Epigenetics 8/1 2019-10-28
2016 Kaarel Krjutškov, Mariann Koel, Anne Mari Roost, Shintaro Katayama, Elisabet Einarsdottir, Eeva-Mari Jouhilahti, Cilla Söderhäll, Ülle Jaakma, Mario Plaas, Liselotte Vesterlund, Hannes Lohi, Andres Salumets, Juha Kere
Globin mRNA reduction for whole-blood transcriptome sequencing
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep31584
Scientific Reports 6/1 2019-10-28
2018 Hindrek Teder, Mariann Koel, Priit Paluoja, Tatjana Jatsenko, Kadri Rekker, Triin Laisk-Podar, Viktorija Kukuškina, Agne Velthut-Meikas, Olga Fjodorova, Maire Peters, Juha Kere, Andres Salumets, Priit Palta, Kaarel Krjutškov
TAC-seq: targeted DNA and RNA sequencing for precise biomarker molecule counting
published pages: , ISSN: 2056-7944, DOI: 10.1038/s41525-018-0072-5
npj Genomic Medicine 3/1 2019-10-28
2018 Heidi Marjonen, Pauliina Auvinen, Hanna Kahila, Olga Tšuiko, Sulev Kõks, Airi Tiirats, Triin Viltrop, Timo Tuuri, Viveca Söderström-Anttila, Anne-Maria Suikkari, Andres Salumets, Aila Tiitinen, Nina Kaminen-Ahola
rs10732516 polymorphism at the IGF2/H19 locus associates with genotype-specific effects on placental DNA methylation and birth weight of newborns conceived by assisted reproductive technology
published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-018-0511-2
Clinical Epigenetics 10/1 2019-10-28
2018 Sakthivignesh Ponandai-Srinivasan, Karin L Andersson, Monica Nister, Merli Saare, Halima A Hassan, Suby J Varghese, Maire Peters, Andres Salumets, Kristina Gemzell-Danielsson, Parameswaran Grace Luther Lalitkumar
Aberrant expression of genes associated with stemness and cancer in endometria and endometrioma in a subset of women with endometriosis
published pages: 1924-1938, ISSN: 0268-1161, DOI: 10.1093/humrep/dey241
Human Reproduction 33/10 2019-10-28
2017 Tiina Drell, Jelena Štšepetova, Jaak Simm, Kristiina Rull, Aira Aleksejeva, Anne Antson, Vallo Tillmann, Madis Metsis, Epp Sepp, Andres Salumets, Reet Mändar
The Influence of Different Maternal Microbial Communities on the Development of Infant Gut and Oral Microbiota
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-09278-y
Scientific Reports 7/1 2019-10-28
2017 L.C. Gemmell, K.E. Webster, S. Kirtley, K. Vincent, K.T. Zondervan, C.M. Becker
The management of menopause in women with a history of endometriosis: a systematic review
published pages: 481-500, ISSN: 1355-4786, DOI: 10.1093/humupd/dmx011
Human Reproduction Update 23/4 2019-10-28
2017 Nilufer Rahmioglu, Alexander W Drong, Helen Lockstone, Thomas Tapmeier, Karin Hellner, Merli Saare, Triin Laisk-Podar, Christine Dew, Emily Tough, George Nicholson, Maire Peters, Andrew P Morris, Cecilia M Lindgren, Christian M Becker, Krina T Zondervan
Variability of genome-wide DNA methylation and mRNA expression profiles in reproductive and endocrine disease related tissues
published pages: 897-908, ISSN: 1559-2294, DOI: 10.1080/15592294.2017.1367475
Epigenetics 12/10 2019-10-28
2017 Viktorija Kukushkina, Vijayachitra Modhukur, Marina Suhorutšenko, Maire Peters, Reedik Mägi, Nilufer Rahmioglu, Agne Velthut-Meikas, Signe Altmäe, Francisco J. Esteban, Jaak Vilo, Krina Zondervan, Andres Salumets, Triin Laisk-Podar
DNA methylation changes in endometrium and correlation with gene expression during the transition from pre-receptive to receptive phase
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-03682-0
Scientific Reports 7/1 2019-10-28
2018 Marina Suhorutshenko, Viktorija Kukushkina, Agne Velthut-Meikas, Signe Altmäe, Maire Peters, Reedik Mägi, Kaarel Krjutškov, Mariann Koel, Francisco M Codoñer, Juan Fco Martinez-Blanch, Felipe Vilella, Carlos Simón, Andres Salumets, Triin Laisk
Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity
published pages: 2074-2086, ISSN: 0268-1161, DOI: 10.1093/humrep/dey301
Human Reproduction 33/11 2019-10-28
2017 Kadri Rekker, Merli Saare, Elo Eriste, Tõnis Tasa, Viktorija Kukuškina, Anne Mari Roost, Kristi Anderson, Külli Samuel, Helle Karro, Andres Salumets, Maire Peters
High-throughput mRNA sequencing of stromal cells from endometriomas and endometrium
published pages: 93-100, ISSN: 1470-1626, DOI: 10.1530/rep-17-0092
Reproduction 154/1 2019-10-28
2018 Kadri Rekker, Signe Altmäe, Marina Suhorutshenko, Maire Peters, Juan F. Martinez-Blanch, Francisco M. Codoñer, Felipe Vilella, Carlos Simón, Andres Salumets, Agne Velthut-Meikas
A Two-Cohort RNA-seq Study Reveals Changes in Endometrial and Blood miRNome in Fertile and Infertile Women
published pages: 574, ISSN: 2073-4425, DOI: 10.3390/genes9120574
Genes 9/12 2019-10-28
2018 Olga Tšuiko, Tatjana Jatsenko, Lalit Kumar Parameswaran Grace, Ants Kurg, Joris Robert Vermeesch, Fredrik Lanner, Signe Altmäe, Andres Salumets
A speculative outlook on embryonic aneuploidy: Can molecular pathways be involved?
published pages: , ISSN: 0012-1606, DOI: 10.1016/j.ydbio.2018.01.014
Developmental Biology 2019-10-28
2018 Martin Sauk, Olga Žilina, Ants Kurg, Eva-Liina Ustav, Maire Peters, Priit Paluoja, Anne Mari Roost, Hindrek Teder, Priit Palta, Nathalie Brison, Joris R. Vermeesch, Kaarel Krjutškov, Andres Salumets, Lauris Kaplinski
NIPTmer: rapid k-mer-based software package for detection of fetal aneuploidies
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-23589-8
Scientific Reports 8/1 2019-10-28

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