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CellViewer SIGNED

CellViewer: super-resolution systems microscopy to assess pluripotency and differentiation of stem cells at single cell level

Total Cost €

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EC-Contrib. €

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Partnership

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Project "CellViewer" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO CENTRE DE REGULACIO GENOMICA 

Organization address
address: CARRER DOCTOR AIGUADER 88
city: BARCELONA
postcode: 8003
website: www.crg.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.cellviewer.eu/
 Total cost 3˙988˙752 €
 EC max contribution 3˙988˙752 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2014-2015-RIA
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO CENTRE DE REGULACIO GENOMICA ES (BARCELONA) coordinator 2˙086˙668.00
2    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) participant 792˙500.00
3    Idea Bio-Medical Ltd. IL (Rehovot) participant 687˙500.00
4    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) participant 293˙334.00
5    LABORATORY IMAGING SRO CZ (PRAHA) participant 128˙750.00
6    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 0.00

Map

 Project objective

In this ambitious and multi-disciplinary proposal, we aim to develop new technologies that will allow us to visualize in single cells, in parallel and at the systems level, DNA, mRNAs and proteins with nanoscale resolution. We will refer to these novel technologies as the ‘CellViewer’: a unique cutting-edge high-throughput super-resolution (SR) microscopy approach (including new hardware and software development) to collect at high-resolution a large amount of spatial and dynamic information in single cells. ‘CellViewer’ will allow us to study the mechanisms of mouse embryonic stem cell (mESC) self-renewal and differentiation upon application of specific stimuli, as a specific test case. We will analyse in single cells with high throughput, DNA remodelling at multiple specific gene loci and their corresponding production, distribution and kinetics of mRNA and protein products. We will collect a large amount of dynamic and nanoscale spatial information that will lead us to build predictive models of the phenotypic output from specific input stimuli. In turn, we will be able to develop a mechanistic understanding of how mESCs maintain their stemness or commit to differentiation. The partners of CellViewer are internationally recognized experts from academia and industry in the fields of stem cell and chromatin biology, super-resolution microscopy, quantitative modelling of biological systems, and hardware and software development. This team as a whole is uniquely suited to bring Systems Biology into the era of single cell analysis, which will be a paradigm shift in the way cellular systems will be studied.

 Deliverables

List of deliverables.
Quality plan Documents, reports 2020-02-07 10:11:20
Project website Websites, patent fillings, videos etc. 2020-02-07 10:11:20

Take a look to the deliverables list in detail:  detailed list of CellViewer deliverables.

 Publications

year authors and title journal last update
List of publications.
2016 Francesco Sottile, Francesco Aulicino, Ilda Theka & Maria Pia Cosma
Mesenchymal stem cells generate distinct functional hybrids in vitro via cell fusion or entosis
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep36863
Scientific Reports 2020-02-07

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The information about "CELLVIEWER" are provided by the European Opendata Portal: CORDIS opendata.

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