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ProNANO SIGNED

Protein-based functional nanostructures

Total Cost €

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EC-Contrib. €

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Partnership

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 ProNANO project word cloud

Explore the words cloud of the ProNANO project. It provides you a very rough idea of what is the project "ProNANO" about.

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Project "ProNANO" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE 

Organization address
address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
city: SAN SEBASTIAN
postcode: 20009
website: www.cicbiomagune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://personal.cicbiomagune.es/alcortajarena/
 Total cost 1˙718˙849 €
 EC max contribution 1˙718˙849 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) coordinator 1˙718˙849.00

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 Project objective

The precise synthesis of nano-devices with tailored complex structures and properties is a requisite for their use in nanotechnology and medicine. Nowadays, the technology for the generation of these devices lacks the precision to determine their properties, and is accomplished mostly by “trial and error” experimental approaches. Bottom-up self-assembly that relies on highly specific biomolecular interactions of small and simple components, is an attractive approach for nanostructure templating. Here, we propose to overcome aforementioned challenges by using self-assembling protein building blocks as templates for nanofabrication. In nature, protein assemblies govern sophisticated structures and functions, which are inspiration to engineer novel assemblies by exploiting the same set of tools and interactions to create nanostructures with numerous potential applications in synthetic biology and nanotechnology. We hypothesize that we can rationally assemble a variety functional nanostructures by the logical combination of simple protein building blocks with specified properties. We propose to use a designed repeat protein scaffold for which we acquired a deep understanding of its molecular structure, stability, function, and inherent assembly properties. Only few conserved residues define the structure of the building block, which allow us to mutate its sequence to modulate assembly properties and to introduce reactive functionalities without compromising the structure of the scaffolding molecule. First, we will design a collection of protein-based nanostructures. Then, we will introduce reactive functionalities to create hybrid nanostructures with nanoparticles, metals and electro-active molecules. Finally, these conjugates will be used to build nano-devices such as nanocircuits, catalysts and electroactive materials. The outcome of this project will be a modular versatile platform for the fabrication of multiple protein-based hybrid functional nanostructures.

 Publications

year authors and title journal last update
List of publications.
2018 Silvia Alonso-de Castro, Aitziber L. Cortajarena, Fernando López-Gallego, Luca Salassa
Bioorthogonal Catalytic Activation of Platinum and Ruthenium Anticancer Complexes by FAD and Flavoproteins
published pages: 3143-3147, ISSN: 1433-7851, DOI: 10.1002/anie.201800288
Angewandte Chemie International Edition 57/12 2019-09-17
2018 Daniel Sanchez-deAlcazar, Sara H. Mejias, Kevin Erazo, Begoña Sot, Aitziber L. Cortajarena
Self-assembly of repeat proteins: Concepts and design of new interfaces
published pages: 118-129, ISSN: 1047-8477, DOI: 10.1016/j.jsb.2017.09.002
Journal of Structural Biology 201/2 2019-09-17
2018 Jatish Kumar, Hasier Eraña, Elena López-Martínez, Nathalie Claes, Víctor F. Martín, Diego M. Solís, Sara Bals, Aitziber L. Cortajarena, Joaquín Castilla, Luis M. Liz-Marzán
Detection of amyloid fibrils in Parkinson’s disease using plasmonic chirality
published pages: 3225-3230, ISSN: 0027-8424, DOI: 10.1073/PNAS.1721690115
Proceedings of the National Academy of Sciences 115/13 2019-09-17
2016 Sara H. Mejias, Antonio Aires, Pierre Couleaud, Aitziber L. Cortajarena
Designed Repeat Proteins as Building Blocks for Nanofabrication
published pages: 61-81, ISSN: , DOI: 10.1007/978-3-319-39196-0_4
Advances in Experimental Medicine and Biology 2019-09-17
2018 Javier López-Andarias, Sara H. Mejías, Tsuneaki Sakurai, Wakana Matsuda, Shu Seki, Ferran Feixas, Sílvia Osuna, Carmen Atienza, Nazario Martín, Aitziber L. Cortajarena
Toward Bioelectronic Nanomaterials: Photoconductivity in Protein-Porphyrin Hybrids Wrapped around SWCNT
published pages: 1704031, ISSN: 1616-301X, DOI: 10.1002/adfm.201704031
Advanced Functional Materials 28/24 2019-09-17
2016 Sara H. Mejias, Pierre Couleaud, Santiago Casado, Daniel Granados, Miguel Angel Garcia, Jose M. Abad, Aitziber L. Cortajarena
Assembly of designed protein scaffolds into monolayers for nanoparticle patterning
published pages: 93-101, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2016.01.039
Colloids and Surfaces B: Biointerfaces 141 2019-09-17
2016 Sara H. Mejías, Javier López-Andarias, Tsuneaki Sakurai, Satoru Yoneda, Kevin P. Erazo, Shu Seki, Carmen Atienza, Nazario Martín, Aitziber L. Cortajarena
Repeat protein scaffolds: ordering photo- and electroactive molecules in solution and solid state
published pages: 4842-4847, ISSN: 2041-6520, DOI: 10.1039/c6sc01306f
Chemical Science 7/8 2019-09-17
2018 Antonio Aires, Elena Lopez-Martinez, Aitziber Cortajarena
Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins
published pages: 110, ISSN: 2079-6374, DOI: 10.3390/bios8040110
Biosensors 8/4 2019-09-17

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