Explore the words cloud of the ProNANO project. It provides you a very rough idea of what is the project "ProNANO" about.
The following table provides information about the project.
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
|Coordinator Country||Spain [ES]|
|Total cost||1˙718˙849 €|
|EC max contribution||1˙718˙849 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-01-01 to 2021-12-31|
Take a look of project's partnership.
|1||ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE||ES (SAN SEBASTIAN)||coordinator||1˙718˙849.00|
The precise synthesis of nano-devices with tailored complex structures and properties is a requisite for their use in nanotechnology and medicine. Nowadays, the technology for the generation of these devices lacks the precision to determine their properties, and is accomplished mostly by “trial and error” experimental approaches. Bottom-up self-assembly that relies on highly specific biomolecular interactions of small and simple components, is an attractive approach for nanostructure templating. Here, we propose to overcome aforementioned challenges by using self-assembling protein building blocks as templates for nanofabrication. In nature, protein assemblies govern sophisticated structures and functions, which are inspiration to engineer novel assemblies by exploiting the same set of tools and interactions to create nanostructures with numerous potential applications in synthetic biology and nanotechnology. We hypothesize that we can rationally assemble a variety functional nanostructures by the logical combination of simple protein building blocks with specified properties. We propose to use a designed repeat protein scaffold for which we acquired a deep understanding of its molecular structure, stability, function, and inherent assembly properties. Only few conserved residues define the structure of the building block, which allow us to mutate its sequence to modulate assembly properties and to introduce reactive functionalities without compromising the structure of the scaffolding molecule. First, we will design a collection of protein-based nanostructures. Then, we will introduce reactive functionalities to create hybrid nanostructures with nanoparticles, metals and electro-active molecules. Finally, these conjugates will be used to build nano-devices such as nanocircuits, catalysts and electroactive materials. The outcome of this project will be a modular versatile platform for the fabrication of multiple protein-based hybrid functional nanostructures.
|year||authors and title||journal||last update|
Silvia Alonso-deâ€…Castro, Aitziber L. Cortajarena, Fernando LÃ³pez-Gallego, Luca Salassa
Bioorthogonal Catalytic Activation of Platinum and Ruthenium Anticancer Complexes by FAD and Flavoproteins
published pages: 3143-3147, ISSN: 1433-7851, DOI: 10.1002/anie.201800288
|Angewandte Chemie International Edition 57/12||2019-09-17|
Daniel Sanchez-deAlcazar, Sara H. Mejias, Kevin Erazo, BegoÃ±a Sot, Aitziber L. Cortajarena
Self-assembly of repeat proteins: Concepts and design of new interfaces
published pages: 118-129, ISSN: 1047-8477, DOI: 10.1016/j.jsb.2017.09.002
|Journal of Structural Biology 201/2||2019-09-17|
Jatish Kumar, Hasier EraÃ±a, Elena LÃ³pez-MartÃnez, Nathalie Claes, VÃctor F. MartÃn, Diego M. SolÃs, Sara Bals, Aitziber L. Cortajarena, JoaquÃn Castilla, Luis M. Liz-MarzÃ¡n
Detection of amyloid fibrils in Parkinsonâ€™s disease using plasmonic chirality
published pages: 3225-3230, ISSN: 0027-8424, DOI: 10.1073/PNAS.1721690115
|Proceedings of the National Academy of Sciences 115/13||2019-09-17|
Sara H. Mejias, Antonio Aires, Pierre Couleaud, Aitziber L. Cortajarena
Designed Repeat Proteins as Building Blocks for Nanofabrication
published pages: 61-81, ISSN: , DOI: 10.1007/978-3-319-39196-0_4
|Advances in Experimental Medicine and Biology||2019-09-17|
Javier LÃ³pez-Andarias, Sara H. MejÃas, Tsuneaki Sakurai, Wakana Matsuda, Shu Seki, Ferran Feixas, SÃlvia Osuna, Carmen Atienza, Nazario MartÃn, Aitziber L. Cortajarena
Toward Bioelectronic Nanomaterials: Photoconductivity in Protein-Porphyrin Hybrids Wrapped around SWCNT
published pages: 1704031, ISSN: 1616-301X, DOI: 10.1002/adfm.201704031
|Advanced Functional Materials 28/24||2019-09-17|
Sara H. Mejias, Pierre Couleaud, Santiago Casado, Daniel Granados, Miguel Angel Garcia, Jose M. Abad, Aitziber L. Cortajarena
Assembly of designed protein scaffolds into monolayers for nanoparticle patterning
published pages: 93-101, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2016.01.039
|Colloids and Surfaces B: Biointerfaces 141||2019-09-17|
Sara H. MejÃas, Javier LÃ³pez-Andarias, Tsuneaki Sakurai, Satoru Yoneda, Kevin P. Erazo, Shu Seki, Carmen Atienza, Nazario MartÃn, Aitziber L. Cortajarena
Repeat protein scaffolds: ordering photo- and electroactive molecules in solution and solid state
published pages: 4842-4847, ISSN: 2041-6520, DOI: 10.1039/c6sc01306f
|Chemical Science 7/8||2019-09-17|
Antonio Aires, Elena Lopez-Martinez, Aitziber Cortajarena
Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins
published pages: 110, ISSN: 2079-6374, DOI: 10.3390/bios8040110
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