Explore the words cloud of the InVivo_DDR_ADPR project. It provides you a very rough idea of what is the project "InVivo_DDR_ADPR" about.
The following table provides information about the project.
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
|Coordinator Country||Germany [DE]|
|Total cost||159˙460 €|
|EC max contribution||159˙460 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-04-01 to 2018-03-31|
Take a look of project's partnership.
|1||MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV||DE (Munich)||coordinator||159˙460.00|
Preservation of genome integrity and stability is critical for survival and propagation of individuals and species. Organisms have thus evolved rapid and efficient mechanisms -collectively termed the DNA damage response (DDR)- to combat threats posed by DNA damage. Among these, the post-translational modification (PTM) ADP-ribosylation (ADPR) plays a decisive role in effective DDR. Although much is known about the relevance of ADPR upon DNA injury, the underlying molecular mechanisms are still poorly understood and no systematic, unbiased proteome-wide study to determine ADPR targets in vivo has been conducted to date. The most challenging and innovative goal of this proposal is to profile in vivo ADP-ribosylated peptides during DDR in the well-established model system Caenorhabditis elegans by the combined application of advanced proteomic approaches. I will develop novel enrichment strategies that will allow me to confidently map for the first time all the sites of ADPR throughout the C. elegans proteome. I will take advantage of SILAN technology, which allows stable isotope labelling in C. elegans, to determine the quantitative profiles of thousands of ADPR sites during DDR. By bioinformatic analysis, I will select candidate proteins for further investigation of the biological role of DNA damage-induced ADPR. I will then test the biological impact of ADPR of these candidates through site-specific mutation of their identified modification sites. Finally, I will perform biochemical, molecular and functional experiments to study how ADPR alters the activity of these proteins and thereby characterize the mode of ADPR action. Understanding the regulatory networks that underlie such a complex biological process at the organism level will provide new insights for improved treatment of DNA damage-related diseases including cancer. This is an ambitious, innovative, cross-disciplinary project at the forefront of two exciting fields, biology and proteomics.
|year||authors and title||journal||last update|
Alisa Zhiteneva, Juan Jose Bonfiglio, Alexandr Makarov, Thomas Colby, Paola Vagnarelli, Eric C. Schirmer, Ivan Matic, William C. Earnshaw
Mitotic post-translational modifications of histones promote chromatin compaction in vitro
published pages: 170076, ISSN: 2046-2441, DOI: 10.1098/rsob.170076
|Open Biology 7/9||2019-06-13|
Orsolya Leidecker, Juan JosÃ© Bonfiglio, Thomas Colby, Qi Zhang, Ilian Atanassov, Roko Zaja, Luca Palazzo, Anna Stockum, Ivan Ahel, Ivan Matic
Serine is a new target residue for endogenous ADP-ribosylation on histones
published pages: 998-1000, ISSN: 1552-4450, DOI: 10.1038/nchembio.2180
|Nature Chemical Biology 12/12||2019-06-13|
Pietro Fontana, Juan JosÃ© Bonfiglio, Luca Palazzo, Edward Bartlett, Ivan Matic, Ivan Ahel
Serine ADP-ribosylation reversal by the hydrolase ARH3
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.28533
Juan JosÃ© Bonfiglio, Pietro Fontana, Qi Zhang, Thomas Colby, Ian Gibbs-Seymour, Ilian Atanassov, Edward Bartlett, Roko Zaja, Ivan Ahel, Ivan Matic
Serine ADP-Ribosylation Depends on HPF1
published pages: 932-940.e6, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.01.003
|Molecular Cell 65/5||2019-06-13|
Juan J. Bonfiglio, Thomas Colby, Ivan Matic
Mass spectrometry for serine ADP-ribosylation? Think o-glycosylation!
published pages: 6259-6264, ISSN: 0305-1048, DOI: 10.1093/nar/gkx446
|Nucleic Acids Research 45/11||2019-06-13|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "INVIVO_DDR_ADPR" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "INVIVO_DDR_ADPR" are provided by the European Opendata Portal: CORDIS opendata.
Natural Product-Inspired Therapies for Leishmaniasis and Chagas DiseaseRead More
Immigration, Attitudes of Natives and Immigrants AssimilationRead More
A multilinear approach to the restriction problem with applications to geometric measure theory, the Schrödinger equation and inverse problemsRead More