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MicMactin SIGNED

Dissecting active matter: Microscopic origins of macroscopic actomyosin activity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MicMactin project word cloud

Explore the words cloud of the MicMactin project. It provides you a very rough idea of what is the project "MicMactin" about.

original    motors    biochemical    behaviors    ing    exertion    controls    molecular    networks    forces    unified    medium    macroscopic    understand    mechanical    regimes    complete    action    self    body    cell    theory    equilibrium    simulations    cytoskeleton    interacting    driving    spanning    structures    function    material    tackle    fundamental    relationship    separately    break    motion    paradigms    recombine    proteins    statistical    achitecture    experimental    tens    cellular    surrounding    originate    actin    physics    disassembly    cytoskeletal    models    context    active    nonequilibrium    ground    branched    unexplored    emergence    collective    scales    filament    motility    collaborations    interact    nanometer    collectively    biology    elasticity    gap    force    fundamentally    foundations    micrometers    disordered    perfectly    assembly    close    regulation    framework    geometry    multiscale    tuned    individual    validated    consistent    generating    biological    interactions    mechanically    experimentally    mechanics    bridge   

Project "MicMactin" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙491˙868 €
 EC max contribution 1˙491˙868 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙491˙868.00

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 Project objective

'Biological motion and forces originate from mechanically active proteins operating at the nanometer scale. These individual active elements interact through the surrounding cellular medium, collectively generating structures spanning tens of micrometers whose mechanical properties are perfectly tuned to their fundamentally out-of-equilibrium biological function. While both individual proteins and the resulting cellular behaviors are well characterized, understanding the relationship between these two scales remains a major challenge in both physics and cell biology.

We will bridge this gap through multiscale models of the emergence of active material properties in the experimentally well-characterized actin cytoskeleton. We will thus investigate unexplored, strongly interacting nonequilibrium regimes. We will develop a complete framework for cytoskeletal activity by separately studying all three fundamental processes driving it out of equilibrium: actin filament assembly and disassembly, force exertion by branched actin networks, and the action of molecular motors. We will then recombine these approaches into a unified understanding of complex cell motility processes.

To tackle the cytoskeleton's disordered geometry and many-body interactions, we will design new nonequilibrium self consistent methods in statistical mechanics and elasticity theory. Our findings will be validated through simulations and close experimental collaborations.

Our work will break new ground in both biology and physics. In the context of biology, it will establish a new framework to understand how the cell controls its achitecture and mechanics through biochemical regulation. On the physics side, it will set up new paradigms for the emergence of original out-of-equilibrium collective behaviors in an experimentally well-characterized system, addressing the foundations of existing macroscopic 'active matter' approaches.'

 Publications

year authors and title journal last update
List of publications.
2017 Florian Rückerl, Martin Lenz, Timo Betz, John Manzi, Jean-Louis Martiel, Mahassine Safouane, Rajaa Paterski-Boujemaa, Laurent Blanchoin, Cécile Sykes
Adaptive Response of Actin Bundles under Mechanical Stress
published pages: 1072-1079, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2017.07.017
Biophysical Journal 113/5 2019-07-08
2016 Giulia Foffano, Nicolas Levernier, Martin Lenz
The dynamics of filament assembly define cytoskeletal network morphology
published pages: 13827, ISSN: 2041-1723, DOI: 10.1038/ncomms13827
Nature Communications 7 2019-07-08
2016 Pierre Ronceray, Chase P. Broedersz, Martin Lenz
Fiber networks amplify active stress
published pages: 2827-2832, ISSN: 0027-8424, DOI: 10.1073/pnas.1514208113
Proceedings of the National Academy of Sciences 113/11 2019-07-08
2018 Cao, Luyan; Kerleau, Mikael; Suzuki, Emiko L.; Wioland, Hugo; Jouet, Sandy; Guichard, Berengere; Lenz, Martin; Romet-Lemonne, Guillaume; Jegou, Antoine
Modulation of formin processivity by profilin and mechanical tension
published pages: e34176, ISSN: 2050-084X, DOI: 10.1101/235333
eLife 7 2019-02-28
2019 Pierre Ronceray, Chase P. Broedersz, Martin Lenz
Fiber plucking by molecular motors yields large emergent contractility in stiff biopolymer networks
published pages: , ISSN: 1744-683X, DOI: 10.1039/c8sm00979a
Soft Matter 2019-02-28
2018 Yu Long Han, Pierre Ronceray, Guoqiang Xu, Andrea Malandrino, Roger D. Kamm, Martin Lenz, Chase P. Broedersz, Ming Guo
Cell contraction induces long-ranged stress stiffening in the extracellular matrix
published pages: 4075-4080, ISSN: 0027-8424, DOI: 10.1073/pnas.1722619115
Proceedings of the National Academy of Sciences 115/16 2019-02-28
2018 Ananyo Maitra, Pragya Srivastava, M. Cristina Marchetti, Juho S. Lintuvuori, Sriram Ramaswamy, Martin Lenz
A nonequilibrium force can stabilize 2D active nematics
published pages: 6934-6939, ISSN: 0027-8424, DOI: 10.1073/pnas.1720607115
Proceedings of the National Academy of Sciences 115/27 2019-02-28
2019 Pierre Ronceray, Chase P. Broedersz, Martin Lenz
Stress-dependent amplification of active forces in nonlinear elastic media
published pages: 331-338, ISSN: 1744-683X, DOI: 10.1039/c8sm00949j
Soft Matter 15/2 2019-02-12

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