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CODIC

COmmercializing first-in-class dCTPase Inhibitors for treatment of hematological Cancers

Total Cost €

EC-Contrib. €

Partnership

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CODIC project word cloud

Explore the words cloud of the CODIC project. It provides you a very rough idea of what is the project "CODIC" about.

plan market drug trials induces selective preclinical validate pharmacokinetic dividing investments holds dctpase business combination nm toxicity networks vivo science 65 model oxcia impd cells secure anti replication screen chemistry apoptosis license discuss ab th1217 direction cancer clinical medical grant mu purified exclusive clinicians company tool hits sirna death rights cytidine commercialization dna ic50 10 enzymatic rnai effort regulatory prepare assay gt explore plays analogues therapies nucleoside cell synergistically 1 inhibit foundation therapy strategy commercial throughput protein compounds potent revealed profit ip medicinal inhibitor nontransformed agencies treatment agency vitro genetic start inhibitors screening house degradation attract bodies shows perform viability owns repair translational erc patients

Project "CODIC" data sheet

The following table provides information about the project.

Coordinator	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-PoC
Funding Scheme	ERC-POC
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2017-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	coordinator	94˙738.00
2	OXCIA AB OXCIA AB Organization address address: FOGDEVRETEN 2A city: SOLNA postcode: 171 65 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (SOLNA)	participant	55˙262.00

Map

Project objective

In our ERC grant GEnetic NEtworks as a tool for anti-CAncer Drug Development we used siRNA screening and genetic networks to identify dCTPase being involved in DNA repair and replication. Further studies revealed that dCTPase plays a role in the degradation of nucleoside analogues used in cancer treatment. We then used an RNAi approach to validate dCTPase as a target to improve nucleoside analogue therapy. The dCTPase protein was purified and we set up an enzymatic high-throughput assay to screen >65,000 compounds, which generated hits that inhibit dCTPase (IC50~1-10μM). Using in house medicinal chemistry we developed TH1217, a low nM potent and selective dCTPase inhibitor with favourable pharmacokinetic properties. TH1217 synergistically induces apoptosis and cell death in combination with cytidine analogue treatment in cancer cells in vitro and in vivo, but shows no increased toxicity in nontransformed dividing cells. Here, we want to explore the commercial potential of the dCTPase inhibitors identified in the ERC grant. In this programme, we will, with the company Oxcia AB, establish the viability of the business programme using technical analysis, develop a business strategy and direction, specifically secure IP, perform market analysis, develop a business plan, manage preclinical development and prepare for clinical trials in collaboration with clinicians and regulatory bodies, IMPD application to Medical Products Agency and identify and discuss with potential commercialization partners and funding agencies to support cost of clinical trials. We have a non-profit foundation that owns our IP rights in an effort to secure long term support for translational science aimed at bringing new therapies to patients. In our planned business model, we start a new company that holds an exclusive license to the IP from the foundation which is used to develop the overall business programme and attract investments.

Publications

List of publications.
year	authors and title	journal	last update
2016	Sabin Llona-Minguez, Andreas HÃ¶glund, Sylvain A. Jacques, Lars Johansson, JosÃ© Manuel CalderÃ³n-MontaÃ±o, Magnus Claesson, Olga Loseva, Nicholas C. K. Valerie, Thomas LundbÃ¤ck, Javier Piedrafita, Giovanni Maga, Emmanuele Crespan, Laurent Meijer, EstefanÃa Burgos MorÃ³n, Pawel Baranczewski, Ann-Louise HagbjÃ¶rk, Richard Svensson, Elisee Wiita, Ingrid AlmlÃ¶f, Torkild Visnes, Fredrik Jeppsson, Kristmundur Sigmundsson, Annika Jenmalm Jensen, Per Artursson, Ann-Sofie Jemth, PÃ¥l Stenmark, Ulrika Warpman Berglund, Martin Scobie, Thomas Helleday Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1 published pages: 1140-1148, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.5b01741	Journal of Medicinal Chemistry 59/3	2019-07-26

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The information about "CODIC" are provided by the European Opendata Portal: CORDIS opendata.