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Targeting reconsolidation to strengthen memories in individuals with Mild Cognitive Impairment

Total Cost €


EC-Contrib. €






 MemoMCI project word cloud

Explore the words cloud of the MemoMCI project. It provides you a very rough idea of what is the project "MemoMCI" about.

memories    precursor    older    structure    age    therapeutic    collaborations    cognitive    healthy    successful    trials    clinical    triggers    reconsolidation    possibility    strengthens    benefit    individuals    critical    data    experiences    fellowship    noninvasive    transcranial    validate    longitudinal    preliminary    training    consolidated    impairment    episodic    adults    mild    functioning    neurorehabilitation    significantly    experimental    health    demonstrated    interventions    polymorphisms    strengthen    daily    form    ad    subjects    urgent    blind    prevent    biomarkers    genetic    disease    life    alzheimer    interdisciplinary    tremendous    decline    tdcs    reactivation    me    shown    opportunity    secondments    double    prefrontal    displays    care    genetics    limited    scientist    multicentre    burdens    accelerated    cortex    delay    neuroplasticity    pfc    placebo    verbal    young    chronic    personal    skills    world    hypothesis    efficacy    brain    degree    time    period    facilitatory    intervention    human    direct    international    memory    variations    amnestic    stimulation    produces    amci    neuroimaging    independent    families   

Project "MemoMCI" data sheet

The following table provides information about the project.


Organization address
address: VIA DEZZA 48
city: MILANO
postcode: 20144
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Memory for unique personal experiences (episodic memory) is critical to daily life functioning. This form of long-term memory also displays the largest degree of age-related decline. This condition is accelerated in amnestic mild cognitive impairment (aMCI), which is often the precursor for emerging Alzheimer’s disease (AD). Since AD produces tremendous chronic burdens on individuals, families and health care systems around the world, the development of effective therapeutic interventions to prevent or delay AD is an urgent international priority. Noninvasive brain stimulation with transcranial direct current (tDCS) has demonstrated efficacy in enhancing long-term memory in healthy human subjects. In addition, reactivation of consolidated memories triggers reconsolidation, a time-limited period during which existing memories can be strengthened. Recent reconsolidation studies in healthy young and older adults have shown that noninvasive stimulation of the prefrontal cortex (PFC) significantly strengthens existing verbal episodic memories. In this double-blind, placebo-controlled study, I test the hypothesis that facilitatory tDCS over the PFC will strengthen existing verbal memories through reconsolidation in individuals with aMCI. In addition, I will determine specific biomarkers to help identify individuals who benefit the most from this tDCS intervention based on variations in brain structure or presence of genetic polymorphisms. These data will provide preliminary information that is crucial for the design of multicentre, longitudinal, placebo-controlled clinical trials, which are needed to validate this novel experimental intervention. This fellowship will provide me with the training in neurorehabilitation, the possibility to learn new skills (neuroimaging and genetics) through secondments, and the opportunity to build the interdisciplinary collaborations I need to become an independent and successful scientist in the field of neuroplasticity.


year authors and title journal last update
List of publications.
2018 Marco Sandrini, Antonio Caronni, Massimo Corbo
Modulating Reconsolidation With Non-invasive Brain Stimulation—Where We Stand and Future Directions
published pages: , ISSN: 1664-1078, DOI: 10.3389/fpsyg.2018.01430
Frontiers in Psychology 9 2019-06-14

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The information about "MEMOMCI" are provided by the European Opendata Portal: CORDIS opendata.

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