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SVDs-at-target SIGNED

Small vessel diseases in a mechanistic perspective: Targets for Intervention Affected pathways and mechanistic exploitation for prevention of stroke and dementia

Total Cost €


EC-Contrib. €






 SVDs-at-target project word cloud

Explore the words cloud of the SVDs-at-target project. It provides you a very rough idea of what is the project "SVDs-at-target" about.

drive    underlying    progress    strokes    blood    compromise    attractive    efficacy    co    extracellular    dementia    vivo    patient    rank    30    technologies    phenotyped    expertise    svds    molecular    proof    exploratory    academic    network    isolated    mechanistic    cellular    basic    shared    individual    ltbp1    made    vessel    encounter    least    ultra    damage    central    diseases    experimental    clinicians    emerged    40    patients    morbidities    applicants    cohorts    fact    timp3    models    health    scientists    separated    roles    human    variability    intervention    defects    point    profound    genetic    interventions    animal    risk    revealed    presentations    brings    treatments    cerebral    validate    szlig    illuminated    relevance    matrix    trials    microvessels    despite    therapeutic    physiological    independent    proteomics    small    tgf    pressing    brain    multiple    link    mri    intersect    clinical    proven    mechanisms    feasibility    expertly    function    barrier    stroke    pressure   

Project "SVDs-at-target" data sheet

The following table provides information about the project.


Organization address
postcode: 80539

contact info
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surname: n.a.
function: n.a.
email: n.a.
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fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 5˙998˙300 €
 EC max contribution 5˙998˙300 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
2    University of Vermont US (BURLINGTON) participant 580˙375.00
3    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) participant 576˙031.00
6    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 555˙375.00
11    ARTTIC FR (PARIS) participant 290˙000.00
12    STROKE ALLIANCE FOR EUROPE BE (BRUSSELS) participant 45˙025.00


 Project objective

Stroke and dementia rank among the most pressing health issues in Europe. Cerebral small vessel diseases (SVDs) have emerged as a central link between these two major co-morbidities. SVDs account for more than 30% of strokes and at least 40% of dementia cases. They encounter multiple distinct diseases that can be separated based on their underlying genetic defects, risk factors, and clinical presentations. Despite this profound impact on human health, there are no treatments with proven efficacy against SVDs. The applicants have made major progress in identifying key mechanisms involved in SVDs and their co-morbidities. We recently identified blood pressure variability as a major independent risk factor for multiple SVDs, stroke, and dementia and illuminated the roles of the blood brain barrier and the extracellular matrix in small vessel function. We further identified novel molecular pathways (TIMP3, LTBP1, TGFß) that are shared between different SVDs and thus point towards common mechanisms. This EU network, which brings together basic scientists and academic clinicians, will make use of novel animal models and expertly phenotyped patient cohorts to identify key mechanisms common to multiple SVDs and determine how these mechanisms contribute to individual SVDs. We will: i) identify common molecular, cellular, and physiological mechanisms that compromise the function of microvessels in different SVDs; ii) determine how these common mechanistic defects intersect to drive brain damage; and iii) validate the relevance of mechanisms through interventions in experimental systems (isolated microvessels and in vivo) and in patients (exploratory proof of concept trials). Our resources including novel animal models and state-of-the art technologies (e.g. proteomics & ultra-high field MRI) as well as expertise in clinical trials support the feasibility of the approach. In fact, studies by the applicants already revealed novel attractive targets for therapeutic intervention.


List of deliverables.
Launch of website, Twitter and LinkedIn account Websites, patent fillings, videos etc. 2020-01-28 10:06:08
Initial Dissemination plan Websites, patent fillings, videos etc. 2020-01-28 10:06:08
Individualized press release for every partner Websites, patent fillings, videos etc. 2020-01-28 10:06:08

Take a look to the deliverables list in detail:  detailed list of SVDs-at-target deliverables.


year authors and title journal last update
List of publications.
2018 Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten-Jacobs, Anne-Katrin Giese, Sander W. van der Laan, Solveig Gretarsdottir, Christopher D. Anderson, Michael Chong, Hieab H. H. Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M. Bartz, Oscar R. Benavente, Steve Bevan, Giorgio B. Boncoraglio, Robert D. Brown, Ad
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
published pages: 524-537, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0058-3
Nature Genetics 50/4 2020-01-28
2017 Joanna M. Wardlaw, Francesca M. Chappell, Maria del Carmen Valdés Hernández, Stephen D.J. Makin, Julie Staals, Kirsten Shuler, Michael J. Thrippleton, Paul A. Armitage, Susana Muñoz-Maniega, Anna K. Heye, Eleni Sakka, Martin S. Dennis
White matter hyperintensity reduction and outcomes after minor stroke
published pages: 10.1212/WNL.0000, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000004328
Neurology 2020-01-28
2017 Anne Joutel, Hugues Chabriat
Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms
published pages: 635-651, ISSN: 0143-5221, DOI: 10.1042/CS20160380
Clinical Science 131/8 2020-01-28
2016 Eric Jouvent, Edouard Duchesnay, Foued Hadj-Selem, François De Guio, Jean-François Mangin, Dominique Hervé, Marco Duering, Stefan Ropele, Reinhold Schmidt, Martin Dichgans, Hugues Chabriat
Prediction of 3-year clinical course in CADASIL
published pages: 1787-1795, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000003252
Neurology 87/17 2020-01-28
2017 C. Eleana Zhang, Sau May Wong, Renske Uiterwijk, Julie Staals, Walter H. Backes, Erik I. Hoff, Tobien Schreuder, Cécile R.L.P.N. Jeukens, Jacobus F.A. Jansen, Robert J. van Oostenbrugge
Intravoxel Incoherent Motion Imaging in Small Vessel Disease
published pages: 658-663, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.116.015084
Stroke 48/3 2020-01-28
2017 Thomas A Longden, Fabrice Dabertrand, Masayo Koide, Albert L Gonzales, Nathan R Tykocki, Joseph E Brayden, David Hill-Eubanks, Mark T Nelson
Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow
published pages: 717-726, ISSN: 1097-6256, DOI: 10.1038/nn.4533
Nature Neuroscience 20/5 2020-01-28
2016 Renske Uiterwijk, Robert J. van Oostenbrugge, Marjolein Huijts, Peter W. De Leeuw, Abraham A. Kroon, Julie Staals
Total Cerebral Small Vessel Disease MRI Score Is Associated with Cognitive Decline in Executive Function in Patients with Hypertension
published pages: , ISSN: 1663-4365, DOI: 10.3389/fnagi.2016.00301
Frontiers in Aging Neuroscience 8 2020-01-28
2016 Gro Klitgaard Povlsen, Thomas A Longden, Adrian D Bonev, David C Hill-Eubanks, Mark T Nelson
Uncoupling of neurovascular communication after transient global cerebral ischemia is caused by impaired parenchymal smooth muscle K ir channel function
published pages: 1195-1201, ISSN: 0271-678X, DOI: 10.1177/0271678X16638350
Journal of Cerebral Blood Flow & Metabolism 36/7 2020-01-28
2017 Rashid Ghaznawi, Jeroen de Bresser, Yolanda van der Graaf, Maarten HT Zwartbol, Theo D Witkamp, Mirjam I Geerlings, Jeroen Hendrikse
Detection and characterization of small infarcts in the caudate nucleus on 7 Tesla MRI: The SMART-MR study
published pages: 0271678X1770597, ISSN: 0271-678X, DOI: 10.1177/0271678X17705974
Journal of Cerebral Blood Flow & Metabolism 2020-01-28
2016 K. Khavandi, R. L. Baylie, S. A. Sugden, M. Ahmed, V. Csato, P. Eaton, D. C. Hill-Eubanks, A. D. Bonev, M. T. Nelson, A. S. Greenstein
Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels
published pages: ra100-ra100, ISSN: 1937-9145, DOI: 10.1126/scisignal.aaf6625
Science Signaling 9/449 2020-01-28
2017 The Lancet Neurology
Vascular disease and neurodegeneration: advancing together
published pages: 333, ISSN: 1474-4422, DOI: 10.1016/S1474-4422(17)30086-8
The Lancet Neurology 16/5 2020-01-28
2017 Virginia E Hawkins, Ana C Takakura, Ashley Trinh, Milene R Malheiros-Lima, Colin M Cleary, Ian C Wenker, Todd Dubreuil, Elliot M Rodriguez, Mark T Nelson, Thiago S Moreira, Daniel K Mulkey
Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.25232
eLife 6 2020-01-28
2016 Martin Dichgans, Joanna Wardlaw, Eric Smith, Vera Zietemann, Sudha Seshadri, Perminder Sachdev, Geert Jan Biessels, Franz Fazekas, Oscar Benavente, Leonardo Pantoni, Frank-Erik De Leeuw, Bo Norrving, Paul Matthews, Christopher Chen, Vincent Mok, Marco Düring, Will Whiteley, Kirsten Shuler, Alvaro Alonso, Sandra E. Black, Carol Brayne, Hugues Chabriat, Charlotte Cordonnier, Fergus Doubal, Emrah Du
METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research
published pages: 1235-1249, ISSN: 1552-5260, DOI: 10.1016/j.jalz.2016.06.004
Alzheimer\'s & Dementia 12/12 2020-01-28
2017 Martin Dichgans, Didier Leys
Vascular Cognitive Impairment
published pages: 573-591, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.116.308426
Circulation Research 120/3 2020-01-28
2017 Matthew Traylor, Rainer Malik, Mike A. Nalls, Ioana Cotlarciuc, Farid Radmanesh, Gudmar Thorleifsson, Ken B. Hanscombe, Carl Langefeld, Danish Saleheen, Natalia S. Rost, Idil Yet, Tim D. Spector, Jordana T. Bell, Eilis Hannon, Jonathan Mill, Ganesh Chauhan, Stephanie Debette, Joshua C. Bis, W.T. Longstreth, M. Arfan Ikram, Lenore J. Launer, Sudha Seshadri, Monica Anne Hamilton-Bruce, Jordi Jimenez
Genetic variation at 16q24.2 is associated with small vessel stroke
published pages: 383-394, ISSN: 0364-5134, DOI: 10.1002/ana.24840
Annals of Neurology 81/3 2020-01-28
2016 Thomas Dalsgaard, Swapnil K. Sonkusare, Cory Teuscher, Matthew E. Poynter, Mark T. Nelson
Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep33841
Scientific Reports 6/1 2020-01-28
2017 Steven A. Lubitz, Owen E. Parsons, Christopher D. Anderson, Emelia J. Benjamin, Rainer Malik, Lu-Chen Weng, Martin Dichgans, Cathie L. Sudlow, Peter M. Rothwell, Jonathan Rosand, Patrick T. Ellinor, Hugh S. Markus, Matthew Traylor
Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms
published pages: 1451-1456, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.116.016198
Stroke 48/6 2020-01-28
2017 Francesca M. Chappell, Maria del Carmen Valdés Hernández, Stephen D. Makin, Kirsten Shuler, Eleni Sakka, Martin S. Dennis, Paul A. Armitage, Susana Muñoz Maniega, Joanna M. Wardlaw
Sample size considerations for trials using cerebral white matter hyperintensity progression as an intermediate outcome at 1 year after mild stroke: results of a prospective cohort study
published pages: , ISSN: 1745-6215, DOI: 10.1186/s13063-017-1825-7
Trials 18/1 2020-01-28
2017 Ellen V. Backhouse, Caroline A. McHutchison, Vera Cvoro, Susan D. Shenkin, Joanna M. Wardlaw
Early life risk factors for cerebrovascular disease
published pages: 976-984, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000003687
Neurology 88/10 2020-01-28
2016 Carmen Capone, Fabrice Dabertrand, Celine Baron-Menguy, Athena Chalaris, Lamia Ghezali, Valérie Domenga-Denier, Stefanie Schmidt, Clément Huneau, Stefan Rose-John, Mark T Nelson, Anne Joutel
Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.17536
eLife 5 2020-01-28
2016 Chenchen Pan, Ruiyao Cai, Francesca Paola Quacquarelli, Alireza Ghasemigharagoz, Athanasios Lourbopoulos, Paweł Matryba, Nikolaus Plesnila, Martin Dichgans, Farida Hellal, Ali Ertürk
Shrinkage-mediated imaging of entire organs and organisms using uDISCO
published pages: 859-867, ISSN: 1548-7091, DOI: 10.1038/nmeth.3964
Nature Methods 13/10 2020-01-28
2017 Caroline A. McHutchison, Ellen V. Backhouse, Vera Cvoro, Susan D. Shenkin, Joanna M. Wardlaw
Education, Socioeconomic Status, and Intelligence in Childhood and Stroke Risk in Later Life
published pages: 608-618, ISSN: 1044-3983, DOI: 10.1097/EDE.0000000000000675
Epidemiology 28/4 2020-01-28
2017 Renske Uiterwijk, Julie Staals, Marjolein Huijts, Peter W. de Leeuw, Abraham A. Kroon, Robert J. van Oostenbrugge
MRI progression of cerebral small vessel disease and cognitive decline in patients with hypertension
published pages: 1263-1270, ISSN: 0263-6352, DOI: 10.1097/HJH.0000000000001294
Journal of Hypertension 35/6 2020-01-28
2017 Susanne J van Veluw, Andy Y Shih, Eric E Smith, Christopher Chen, Julie A Schneider, Joanna M Wardlaw, Steven M Greenberg, Geert Jan Biessels
Detection, risk factors, and functional consequences of cerebral microinfarcts
published pages: , ISSN: 1474-4422, DOI: 10.1016/S1474-4422(17)30196-5
The Lancet Neurology 2020-01-28
2017 Minghuan Wang, Fengfei Ding, SaiYue Deng, Xuequn Guo, Wei Wang, Jeffrey J. Iliff, Maiken Nedergaard
Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts
published pages: 2870-2877, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.2112-16.2017
The Journal of Neuroscience 37/11 2020-01-28
2017 Gordon W. Blair, Maria Valdez Hernandez, Michael J. Thrippleton, Fergus N. Doubal, Joanna M. Wardlaw
Advanced Neuroimaging of Cerebral Small Vessel Disease
published pages: , ISSN: 1092-8464, DOI: 10.1007/s11936-017-0555-1
Current Treatment Options in Cardiovascular Medicine 19/7 2020-01-28
2017 Maria del C. Valdés Hernández, Victor González-Castro, Francesca M. Chappell, Eleni Sakka, Stephen Makin, Paul A. Armitage, William H. Nailon, Joanna M. Wardlaw
Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity
published pages: , ISSN: 1664-2295, DOI: 10.3389/fneur.2017.00327
Frontiers in Neurology 8 2020-01-28
2016 Swapnil K. Sonkusare, Thomas Dalsgaard, Adrian D. Bonev, Mark T. Nelson
Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators
published pages: 3271-3285, ISSN: 0022-3751, DOI: 10.1113/JP271652
The Journal of Physiology 594/12 2020-01-28
2017 Víctor González-Castro, María del C. Valdés Hernández, Francesca M. Chappell, Paul A. Armitage, Stephen Makin, Joanna M. Wardlaw
Reliability of an automatic classifier for brain enlarged perivascular spaces burden and comparison with human performance
published pages: 1465-1481, ISSN: 0143-5221, DOI: 10.1042/CS20170051
Clinical Science 131/13 2020-01-28
2018 Julien Ratelade, Nicolas Mezouar, Valérie Domenga-Denier, Ambre Rochey, Emmanuelle Plaisier, Anne Joutel
Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke
published pages: 408-420, ISSN: 0022-3417, DOI: 10.1002/path.5023
The Journal of Pathology 244/4 2020-01-28
2018 Juhana Frösen, Anne Joutel
Smooth muscle cells of intracranial vessels: from development to disease
published pages: 501-512, ISSN: 0008-6363, DOI: 10.1093/cvr/cvy002
Cardiovascular Research 114/4 2020-01-28
2018 Kui Kai Lau, Caroline E. Lovelock, Linxin Li, Michela Simoni, Sergei Gutnikov, Wilhelm Küker, Henry Ka Fung Mak, Peter M. Rothwell
Antiplatelet Treatment After Transient Ischemic Attack and Ischemic Stroke in Patients With Cerebral Microbleeds in 2 Large Cohorts and an Updated Systematic Review
published pages: 1434-1442, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.117.020104
Stroke 49/6 2020-01-28
2018 Catherine A Humphreys, Maurits A Jansen, Susana Muñoz Maniega, Víctor González-Castro, Cyril Pernet, Ian J Deary, Rustam Al-Shahi Salman, Joanna M Wardlaw, Colin Smith
A protocol for precise comparisons of small vessel disease lesions between ex vivo magnetic resonance imaging and histopathology
published pages: 174749301879996, ISSN: 1747-4930, DOI: 10.1177/1747493018799962
International Journal of Stroke 2020-01-28
2018 Enrico Pellegrini, Lucia Ballerini, Maria del C. Valdes Hernandez, Francesca M. Chappell, Victor González-Castro, Devasuda Anblagan, Samuel Danso, Susana Muñoz-Maniega, Dominic Job, Cyril Pernet, Grant Mair, Tom J. MacGillivray, Emanuele Trucco, Joanna M. Wardlaw
Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: A systematic review
published pages: 519-535, ISSN: 2352-8729, DOI: 10.1016/j.dadm.2018.07.004
Alzheimer\'s & Dementia: Diagnosis, Assessment & Disease Monitoring 10 2020-01-28
2017 Stephen DJ Makin, Fergus N Doubal, Terence J Quinn, Philip MW Bath, Martin S Dennis, Joanna M Wardlaw
The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke
published pages: 66-73, ISSN: 2396-9873, DOI: 10.1177/2396987317728854
European Stroke Journal 3/1 2020-01-28
2018 Humberto Mestre, Jeffrey Tithof, Ting Du, Wei Song, Weiguo Peng, Amanda M. Sweeney, Genaro Olveda, John H. Thomas, Maiken Nedergaard, Douglas H. Kelley
Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07318-3
Nature Communications 9/1 2020-01-28
2019 Michael Jonathan Thrippleton
MRI measurement of blood-brain barrier leakage: minding the gaps
published pages: 667-668, ISSN: 0022-3751, DOI: 10.1113/jp277425
The Journal of Physiology 597/3 2020-01-28
2018 Caroline M.J. Loos, Stephen D.J. Makin, Julie Staals, Martin S. Dennis, Robert J. van Oostenbrugge, Joanna M. Wardlaw
Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging
published pages: 1183-1188, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.117.020495
Stroke 49/5 2020-01-28
2019 Ganesh Chauhan, Hieab H.H. Adams, Claudia L. Satizabal, Joshua C. Bis, Alexander Teumer, Muralidharan Sargurupremraj, Edith Hofer, Stella Trompet, Saima Hilal, Albert Vernon Smith, Xueqiu Jian, Rainer Malik, Matthew Traylor, Sara L. Pulit, Philippe Amouyel, Bernard Mazoyer, Yi-Cheng Zhu, Sara Kaffashian, Sabrina Schilling, Gary W. Beecham, Thomas J. Montine, Gerard D. Schellenberg, Olafur Kjartans
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting
published pages: e486-e503, ISSN: 0028-3878, DOI: 10.1212/wnl.0000000000006851
Neurology 92/5 2020-01-28
2019 Michael Thrippleton, Gordon Blair, Maria Valdes-Hernandez, Andreas Glatz, Scott Semple, Fergus Doubal, Alex Vesey, Ian Marshall, David Newby, Joanna Wardlaw
MRI Relaxometry for Quantitative Analysis of USPIO Uptake in Cerebral Small Vessel Disease
published pages: 776, ISSN: 1422-0067, DOI: 10.3390/ijms20030776
International Journal of Molecular Sciences 20/3 2020-01-28
2018 Linxin Li, Sarah J.V. Welch, Sergei A. Gutnikov, Ziyah Mehta, Peter M. Rothwell
Time course of blood pressure control prior to lacunar TIA and stroke
published pages: e1732-e1741, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000005526
Neurology 90/20 2020-01-28
2018 Ellen V. Backhouse, Caroline A. McHutchison, Vera Cvoro, Susan D. Shenkin, Joanna M. Wardlaw
Cognitive ability, education and socioeconomic status in childhood and risk of post-stroke depression in later life: A systematic review and meta-analysis
published pages: e0200525, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0200525
PLOS ONE 13/7 2020-01-28
2019 Marios K. Georgakis, Dipender Gill, Kristiina Rannikmäe, Matthew Traylor, Christopher D. Anderson, Jin-Moo Lee, Yoichiro Kamatani, Jemma C. Hopewell, Bradford B. Worrall, Jürgen Bernhagen, Cathie L. M. Sudlow, Rainer Malik, Martin Dichgans
Genetically Determined Levels of Circulating Cytokines and Risk of Stroke
published pages: 256-268, ISSN: 0009-7322, DOI: 10.1161/circulationaha.118.035905
Circulation 139/2 2020-01-28
2017 Gordon W Blair, Jason P Appleton, Zhe Kang Law, Fergus Doubal, Katie Flaherty, Richard Dooley, Kirsten Shuler, Carla Richardson, Iona Hamilton, Yulu Shi, Michael Stringer, Julia Boyd, Michael J Thrippleton, Nikola Sprigg, Philip M Bath, Joanna M Wardlaw
Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination
published pages: 530-538, ISSN: 1747-4930, DOI: 10.1177/1747493017731947
International Journal of Stroke 13/5 2020-01-28
2018 Yulu Shi, Michael J Thrippleton, Gordon W Blair, David A Dickie, Ian Marshall, Iona Hamilton, Fergus N Doubal, Francesca Chappell, Joanna M Wardlaw
Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow
published pages: 0271678X1880395, ISSN: 0271-678X, DOI: 10.1177/0271678x18803956
Journal of Cerebral Blood Flow & Metabolism 2020-01-28
2018 Lennart J. Geurts, Alex A. Bhogal, Jeroen C.W. Siero, Peter R. Luijten, Geert Jan Biessels, Jaco J.M. Zwanenburg
Vascular reactivity in small cerebral perforating arteries with 7 T phase contrast MRI – A proof of concept study
published pages: 470-477, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2018.01.055
NeuroImage 172 2020-01-28
2018 Yulu Shi, Michael J. Thrippleton, Ian Marshall, Joanna M. Wardlaw
Intracranial pulsatility in patients with cerebral small vessel disease: a systematic review
published pages: 157-171, ISSN: 0143-5221, DOI: 10.1042/cs20171280
Clinical Science 132/1 2020-01-28
2018 Benjamin A. Plog, Maiken Nedergaard
The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future
published pages: 379-394, ISSN: 1553-4006, DOI: 10.1146/annurev-pathol-051217-111018
Annual Review of Pathology: Mechanisms of Disease 13/1 2020-01-28
2018 Bian Liu, Kui Kai Lau, Linxin Li, Caroline Lovelock, Ming Liu, Wilhelm Kuker, Peter M. Rothwell
Age-Specific Associations of Renal Impairment With Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Transient Ischemic Attack and Stroke
published pages: 899-904, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.117.019650
Stroke 49/4 2020-01-28
2018 Alastair J.S. Webb, Sara Mazzucco, Linxin Li, Peter M. Rothwell
Prognostic Significance of Blood Pressure Variability on Beat-to-Beat Monitoring After Transient Ischemic Attack and Stroke
published pages: 62-67, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.117.019107
Stroke 49/1 2020-01-28
2018 Caroline A McHutchison, Vera Cvoro, Stephen Makin, Francesca M Chappell, Kirsten Shuler, Joanna M Wardlaw
Functional, cognitive and physical outcomes 3 years after minor lacunar or cortical ischaemic stroke
published pages: jnnp-2018-319134, ISSN: 0022-3050, DOI: 10.1136/jnnp-2018-319134
Journal of Neurology, Neurosurgery & Psychiatry 2020-01-28
2017 Michael J Thrippleton, Yulu Shi, Gordon Blair, Iona Hamilton, Gordon Waiter, Christian Schwarzbauer, Cyril Pernet, Peter JD Andrews, Ian Marshall, Fergus Doubal, Joanna M Wardlaw
Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing
published pages: 195-206, ISSN: 1747-4930, DOI: 10.1177/1747493017730740
International Journal of Stroke 13/2 2020-01-28
2019 Farah Francis, Lucia Ballerini, Joanna M Wardlaw
Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: A systematic review and meta-analysis
published pages: 174749301983032, ISSN: 1747-4930, DOI: 10.1177/1747493019830321
International Journal of Stroke 2020-01-28
2018 Emma L. Bailey, Martin W. McBride, John D. McClure, Wendy Beattie, Delyth Graham, Anna F. Dominiczak, Colin Smith, Joanna M. Wardlaw
Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease
published pages: 1315-1328, ISSN: 0143-5221, DOI: 10.1042/cs20171572
Clinical Science 132/12 2020-01-28
2018 Alice M Harper, Lauren Clayson, Joanna M Wardlaw, Maria del C Valdés Hernández
Considerations on accuracy, pattern and possible underlying factors of brain microbleed progression in older adults with absence or mild presence of vascular pathology
published pages: 3518-3538, ISSN: 0300-0605, DOI: 10.1177/0300060518755623
Journal of International Medical Research 46/9 2020-01-28
2018 Osama F Harraz, Thomas A Longden, David Hill-Eubanks, Mark T Nelson
PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.38689
eLife 7 2020-01-28
2017 Vera Zietemann, Anna Kopczak, Claudia Müller, Frank Arne Wollenweber, Martin Dichgans
Validation of the Telephone Interview of Cognitive Status and Telephone Montreal Cognitive Assessment Against Detailed Cognitive Testing and Clinical Diagnosis of Mild Cognitive Impairment After Stroke
published pages: 2952-2957, ISSN: 0039-2499, DOI: 10.1161/strokeaha.117.017519
Stroke 48/11 2020-01-28
2018 Simon R. Cox, Mike Allerhand, Stuart J. Ritchie, Susana Muñoz Maniega, Maria Valdés Hernández, Sarah E. Harris, David Alexander Dickie, Devasuda Anblagan, Benjamin S. Aribisala, Zoe Morris, Roy Sherwood, N. Joan Abbott, John M. Starr, Mark E. Bastin, Joanna M. Wardlaw, Ian J. Deary
Longitudinal serum S100β and brain aging in the Lothian Birth Cohort 1936
published pages: 274-282, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2018.05.029
Neurobiology of Aging 69 2020-01-28
2017 Kristiina Rannikmäe, Vhinoth Sivakumaran, Henry Millar, Rainer Malik, Christopher D. Anderson, Mike Chong, Tushar Dave, Guido J. Falcone, Israel Fernandez-Cadenas, Jordi Jimenez-Conde, Arne Lindgren, Joan Montaner, Martin O\'Donnell, Guillaume Paré, Farid Radmanesh, Natalia S. Rost, Agnieszka Slowik, Martin Söderholm, Matthew Traylor, Sara L. Pulit, Sudha Seshadri, Brad B. Worrall, Daniel Woo, H
COL4A2 is associated with lacunar ischemic stroke and deep ICH
published pages: 1829-1839, ISSN: 0028-3878, DOI: 10.1212/wnl.0000000000004560
Neurology 89/17 2020-01-28
2018 Andreas Zellner, Eva Scharrer, Thomas Arzberger, Chio Oka, Valérie Domenga-Denier, Anne Joutel, Stefan F. Lichtenthaler, Stephan A. Müller, Martin Dichgans, Christof Haffner
CADASIL brain vessels show a HTRA1 loss-of-function profile
published pages: 111-125, ISSN: 0001-6322, DOI: 10.1007/s00401-018-1853-8
Acta Neuropathologica 136/1 2020-01-28
2018 Renske Uiterwijk, Julie Staals, Marjolein Huijts, Sander M. J. van Kuijk, Peter W. de Leeuw, Abraham A. Kroon, Robert J. van Oostenbrugge
Hypertensive organ damage predicts future cognitive performance: A 9-year follow-up study in patients with hypertension
published pages: 1458-1463, ISSN: 1524-6175, DOI: 10.1111/jch.13372
The Journal of Clinical Hypertension 20/10 2020-01-28
2018 Steffen Tiedt, Martin Dichgans
Role of Non-Coding RNAs in Stroke
published pages: 3098-3106, ISSN: 0039-2499, DOI: 10.1161/strokeaha.118.021010
Stroke 49/12 2020-01-28
2017 Caroline MJ Loos, Caroline McHutchison, Vera Cvoro, Stephen DJ Makin, Julie Staals, Francesca Chappell, Martin S Dennis, Robert J van Oostenbrugge, Joanna M Wardlaw
The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke
published pages: 518-524, ISSN: 1747-4930, DOI: 10.1177/1747493017730780
International Journal of Stroke 13/5 2020-01-28
2018 Steffen Tiedt, Marco Duering, Christian Barro, Asli Gizem Kaya, Julia Boeck, Felix J. Bode, Matthias Klein, Franziska Dorn, Benno Gesierich, Lars Kellert, Birgit Ertl-Wagner, Michael W. Goertler, Gabor C. Petzold, Jens Kuhle, Frank A. Wollenweber, Nils Peters, Martin Dichgans
Serum neurofilament light
published pages: e1338-e1347, ISSN: 0028-3878, DOI: 10.1212/wnl.0000000000006282
Neurology 91/14 2020-01-28
2017 Steffen Tiedt, Matthias Prestel, Rainer Malik, Nicola Schieferdecker, Marco Duering, Veronika Kautzky, Ivelina Stoycheva, Julia Böck, Bernd H. Northoff, Matthias Klein, Franziska Dorn, Knut Krohn, Daniel Teupser, Arthur Liesz, Nikolaus Plesnila, Lesca Miriam Holdt, Martin Dichgans
RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke
published pages: 970-980, ISSN: 0009-7330, DOI: 10.1161/circresaha.117.311572
Circulation Research 121/8 2020-01-28
2019 Martin Dichgans
Dementia risk after transient ischaemic attack and stroke
published pages: 223-225, ISSN: 1474-4422, DOI: 10.1016/s1474-4422(18)30497-6
The Lancet Neurology 18/3 2020-01-28

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