GAMBA

Gene Activated Matrices for Bone and Cartilage Regeneration in Arthritis

 Coordinatore KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN 

 Organization address address: ISMANINGER STRASSE 22
city: MUENCHEN
postcode: 81675

contact info
Nome: Renate
Cognome: Rädlein
Email: send email
Telefono: 498941000000
Fax: 498941000000

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://www.gamba-project.eu/
 Totale costo 4˙080˙393 €
 EC contributo 3˙198˙849 €
 Programma FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
 Code Call FP7-NMP-2009-SMALL-3
 Funding Scheme CP-FP
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-09-01   -   2013-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

 Organization address address: ISMANINGER STRASSE 22
city: MUENCHEN
postcode: 81675

contact info
Nome: Renate
Cognome: Rädlein
Email: send email
Telefono: 498941000000
Fax: 498941000000

DE (MUENCHEN) coordinator 619˙792.00
2    AO-FORSCHUNGSINSTITUT DAVOS

 Organization address address: Clavadelerstrasse 8
city: Davos Platz
postcode: 7270

contact info
Titolo: Prof.
Nome: Mauro
Cognome: Alini
Email: send email
Telefono: +41 81 414 23 10

CH (Davos Platz) participant 457˙798.00
3    NATIONAL UNIVERSITY OF IRELAND, GALWAY

 Organization address address: University Road -
city: GALWAY

contact info
Titolo: Mr.
Nome: Roger
Cognome: Sweetman
Email: send email
Telefono: 35391492715
Fax: 35391495570

IE (GALWAY) participant 381˙999.00
4    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

 Organization address address: 's Gravendijkwal 230
city: ROTTERDAM
postcode: 3015CE

contact info
Titolo: Prof.
Nome: Gerjo
Cognome: Van Osch
Email: send email
Telefono: 31107043661
Fax: 31107044690

NL (ROTTERDAM) participant 354˙200.00
5    BIOMATLANTE SAS

 Organization address address: rue Edouard Belin - ZA des IV Nations 5
city: VIGNEUX DE BRETAGNE
postcode: 44360

contact info
Titolo: Ms.
Nome: Chantal
Cognome: Gobin
Email: send email
Telefono: 33228020009
Fax: 33228020010

FR (VIGNEUX DE BRETAGNE) participant 349˙560.00
6    OZ BIOSCIENCES SAS

 Organization address address: Parc scientifique et Technologique de Luminy - BAT CCIMP
city: MARSEILLE
postcode: 13288

contact info
Titolo: Dr.
Nome: Olivier
Cognome: Zelphati
Email: send email
Telefono: 33486948514
Fax: 33486948515

FR (MARSEILLE) participant 330˙800.00
7    IRCCS AZIENDA OSPEDALIERA UNIVERSITARIA SAN MARTINO-IST-ISTITUTO NAZIONALE PER LA RICERCA SUL CANCRO

 Organization address address: LARGO ROSANNA BENZI 10
city: GENOVA
postcode: 16132

contact info
Titolo: Dr.
Nome: Gian Franco
Cognome: Ciappina
Email: send email
Telefono: +39 010 5600416
Fax: +39 010 358032

IT (GENOVA) participant 269˙600.00
8    Nome Ente NON disponibile

 Organization address city: Weilheim
postcode: 82362

contact info
Titolo: Dr.
Nome: Katharina
Cognome: Zöller
Email: send email
Telefono: +49 881 9245 1381
Fax: +49 881 9245 1381

DE (Weilheim) participant 244˙600.00
9    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Agnès
Cognome: Debret
Email: send email
Telefono: 33240350669
Fax: 33240477701

FR (PARIS) participant 190˙500.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

innovative    platform    public    activated    physical    repair    matrix    cells    nanoparticles    bioactivity    natural    gene    vectors    stimuli    expression    modules    spatiotemporal    biological    spatial    tissue    vector   

 Obiettivo del progetto (Objective)

'This consortium develops a novel gene-activated matrix platform for bone and cartilage repair with a focus on osteoarthritis-related tissue damage. The S&T objectives of this project are complemented with an innovative program of public outreach, actively linking patients and society to the evolvement of this project. The GAMBA platform is going to implement a concept of spatiotemporal control of regenerative bioactivity on command and demand. A gene-activated matrix is a biomaterial with embedded gene vectors that will genetically modify cells embedded in the matrix. The platform comprises modules that self-adapt to the biological environment and that can be independently addressed with endogenous biological and exogenous physical or pharmacological stimuli, resulting in a temporally and spatially coordinated growth factor gene expression pattern. This reproduces, within the matrix, key elements of natural tissue formation. The modules are a biomimetic hyaluronan gel, a ceramic matrix, growth factor-encoding gene vector nanoparticles, magnetic nanoparticles and mesenchymal stem cells. Anatomical adaptivity is achieved with engineered thermal properties of the polymer matrix, which embeds other modules, selected according to functional requirements. Mechanical support is provided by Micro Macroporous Biphasic Calcium Phosphate (MBCP™), a resorbable material approved for clinical use. Spatiotemporal control of bioactivity and responsiveness to physiological conditions is represented, firstly, in the spatial distribution and release profiles of gene vectors within the composite matrix and, secondly, by letting local and external biological or physical stimuli activate the promoters driving the expression of vector-encoded transgenes. This innovative concept is implemented by a multidisciplinary team from leading European institutions combining scientific excellence with a focused plan of dissemination, public participation, gender equality and transition to market.'

Introduzione (Teaser)

Exploiting the natural processes of tissue regeneration and repair could constitute a promising approach for reversing many degenerative disorders. However, reproducing exactly what happens in nature requires tight spatial and temporal control.

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