GAMBA

Gene Activated Matrices for Bone and Cartilage Regeneration in Arthritis

Coordinatore	KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN    more  Organization address address: ISMANINGER STRASSE 22 city: MUENCHEN postcode: 81675 contact info Nome: Renate Cognome: Rädlein Email: send email Telefono: 498941000000 Fax: 498941000000
Nazionalità Coordinatore	Germany [DE]
Sito del progetto	http://www.gamba-project.eu/
Totale costo	4˙080˙393 €
EC contributo	3˙198˙849 €
Programma	FP7-NMP Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
Code Call	FP7-NMP-2009-SMALL-3
Funding Scheme	CP-FP
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-09-01   -   2013-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN  Organization address address: ISMANINGER STRASSE 22 city: MUENCHEN postcode: 81675 contact info Nome: Renate Cognome: Rädlein Email: send email Telefono: 498941000000 Fax: 498941000000	DE (MUENCHEN)	coordinator	619˙792.00
2	AO-FORSCHUNGSINSTITUT DAVOS  Organization address address: Clavadelerstrasse 8 city: Davos Platz postcode: 7270 contact info Titolo: Prof. Nome: Mauro Cognome: Alini Email: send email Telefono: +41 81 414 23 10	CH (Davos Platz)	participant	457˙798.00
3	NATIONAL UNIVERSITY OF IRELAND, GALWAY  Organization address address: University Road - city: GALWAY contact info Titolo: Mr. Nome: Roger Cognome: Sweetman Email: send email Telefono: 35391492715 Fax: 35391495570	IE (GALWAY)	participant	381˙999.00
4	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM  Organization address address: 's Gravendijkwal 230 city: ROTTERDAM postcode: 3015CE contact info Titolo: Prof. Nome: Gerjo Cognome: Van Osch Email: send email Telefono: 31107043661 Fax: 31107044690	NL (ROTTERDAM)	participant	354˙200.00
5	BIOMATLANTE SAS  Organization address address: rue Edouard Belin - ZA des IV Nations 5 city: VIGNEUX DE BRETAGNE postcode: 44360 contact info Titolo: Ms. Nome: Chantal Cognome: Gobin Email: send email Telefono: 33228020009 Fax: 33228020010	FR (VIGNEUX DE BRETAGNE)	participant	349˙560.00
6	OZ BIOSCIENCES SAS  Organization address address: Parc scientifique et Technologique de Luminy - BAT CCIMP city: MARSEILLE postcode: 13288 contact info Titolo: Dr. Nome: Olivier Cognome: Zelphati Email: send email Telefono: 33486948514 Fax: 33486948515	FR (MARSEILLE)	participant	330˙800.00
7	IRCCS AZIENDA OSPEDALIERA UNIVERSITARIA SAN MARTINO-IST-ISTITUTO NAZIONALE PER LA RICERCA SUL CANCRO  Organization address address: LARGO ROSANNA BENZI 10 city: GENOVA postcode: 16132 contact info Titolo: Dr. Nome: Gian Franco Cognome: Ciappina Email: send email Telefono: +39 010 5600416 Fax: +39 010 358032	IT (GENOVA)	participant	269˙600.00
8	Nome Ente NON disponibile  Organization address city: Weilheim postcode: 82362 contact info Titolo: Dr. Nome: Katharina Cognome: Zöller Email: send email Telefono: +49 881 9245 1381 Fax: +49 881 9245 1381	DE (Weilheim)	participant	244˙600.00
9	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Ms. Nome: Agnès Cognome: Debret Email: send email Telefono: 33240350669 Fax: 33240477701	FR (PARIS)	participant	190˙500.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'This consortium develops a novel gene-activated matrix platform for bone and cartilage repair with a focus on osteoarthritis-related tissue damage. The S&T objectives of this project are complemented with an innovative program of public outreach, actively linking patients and society to the evolvement of this project. The GAMBA platform is going to implement a concept of spatiotemporal control of regenerative bioactivity on command and demand. A gene-activated matrix is a biomaterial with embedded gene vectors that will genetically modify cells embedded in the matrix. The platform comprises modules that self-adapt to the biological environment and that can be independently addressed with endogenous biological and exogenous physical or pharmacological stimuli, resulting in a temporally and spatially coordinated growth factor gene expression pattern. This reproduces, within the matrix, key elements of natural tissue formation. The modules are a biomimetic hyaluronan gel, a ceramic matrix, growth factor-encoding gene vector nanoparticles, magnetic nanoparticles and mesenchymal stem cells. Anatomical adaptivity is achieved with engineered thermal properties of the polymer matrix, which embeds other modules, selected according to functional requirements. Mechanical support is provided by Micro Macroporous Biphasic Calcium Phosphate (MBCP™), a resorbable material approved for clinical use. Spatiotemporal control of bioactivity and responsiveness to physiological conditions is represented, firstly, in the spatial distribution and release profiles of gene vectors within the composite matrix and, secondly, by letting local and external biological or physical stimuli activate the promoters driving the expression of vector-encoded transgenes. This innovative concept is implemented by a multidisciplinary team from leading European institutions combining scientific excellence with a focused plan of dissemination, public participation, gender equality and transition to market.'

Introduzione (Teaser)

Exploiting the natural processes of tissue regeneration and repair could constitute a promising approach for reversing many degenerative disorders. However, reproducing exactly what happens in nature requires tight spatial and temporal control.