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MIB SIGNED

Multi-modal, Endoscopic Biophotonic Imaging of Bladder Cancer for Point-of-Care Diagnosis

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MIB" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://mib-h2020.eu
 Total cost 5˙983˙807 €
 EC max contribution 5˙983˙807 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 829˙254.00
2    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) participant 689˙078.00
3    FORSCHUNGSVERBUND BERLIN EV DE (BERLIN) participant 669˙582.00
4    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) participant 655˙046.00
5    LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V. DE (JENA) participant 653˙875.00
6    M-SQUARED LASERS LIMITED UK (GLASGOW) participant 512˙500.00
7    2M ENGINEERING LIMITED UK (FOLKSTONE) participant 502˙102.00
8    REGION HOVEDSTADEN DK (HILLEROD) participant 479˙081.00
9    Blazejewski MEDI-TECH GMBH DE (Sexau) participant 432˙812.00
10    GRINTECH GMBH DE (Jena) participant 365˙475.00
11    ALBERT-LUDWIGS-UNIVERSITAET FREIBURG DE (FREIBURG) participant 195˙000.00

Map

 Project objective

Bladder cancer is among the most expensive diseases in oncology in terms of treatment costs; each procedure requires days of hospitalisation and recurrence rates are high. Current unmet clinical needs can be addressed by optical methods due to the combination of non-invasive and real-time capture of unprecedented biomedical information. The MIB objective is to provide robust, easy-to-use, cost-effective optical methods with superior sensitivity and specificity to enable a step-change in point-of-care diagnostics of bladder cancer. The concept relies on combining optical methods (optical coherence tomography, multi-spectral opto-acoustic tomography, shifted excitation Raman difference spectroscopy, and multiphoton microscopy) providing structural, biochemical and functional information. The hypothesis is that such combination enables in situ diagnosis of bladder cancer with superior sensitivity and specificity due to unprecedented combined anatomic, biochemical and molecular tissue information. The step-change is that this hybrid concept is provided endoscopically for in vivo clinical use. The project relies on development of new light sources, high-speed imaging systems, unique imaging fibre bundles, and endoscopes, combined and applied clinically. The consortium comprises world-leading academic organisations in a strong partnership with innovative SMEs and clinical end-users. Through commercialization of this novel imaging platform, MIB is expected to reinforce leading market positions in medical devices and healthcare for the SMEs in areas where European industry is already strong. The impact is that improved diagnostic procedures facilitate earlier onset of effective treatment, thus recurrence and follow-up procedures would be reduced by 10%, i.e., reducing costs. Using MIB technology, healthcare cost savings in the order of 360M€ are expected for the whole EU. Equally important, prognosis and patient quality of life would improve drastically.

 Deliverables

List of deliverables.
Project Website Demonstrators, pilots, prototypes 2020-04-07 20:27:06

Take a look to the deliverables list in detail:  detailed list of MIB deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Fabian Placzek, Eliana Cordero Bautista, Simon Kretschmer, Lara M. Wurster, Florian Knorr, Gerardo González-Cerdas, Mikael T. Erkkilä, Patrick Stein, Çağlar Ataman, Gregers G. Hermann, Karin Mogensen, Thomas Hasselager, Peter E. Andersen, Hans Zappe, Jürgen Popp, Wolfgang Drexler, Rainer A. Leitgeb, Iwan W. Schie
Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscopy
published pages: , ISSN: 0003-2654, DOI: 10.1039/c9an01911a
The Analyst 2020-04-07
2018 Martin Maiwald, Bernd Sumpf, Günther Tränkle
Rapid and adjustable shifted excitation Raman difference spectroscopy using a dual-wavelength diode laser at 785 nm
published pages: , ISSN: 0377-0486, DOI: 10.1002/jrs.5456
Journal of Raman Spectroscopy 2020-04-07
2018 Daniela Bovenkamp, Ryan Sentosa, Elisabet Rank, Mikael Erkkilä, Fabian Placzek, Jeremias Püls, Wolfgang Drexler, Rainer Leitgeb, Nathalie Garstka, Shahrokh Shariat, Clara Stiebing, Iwan Schie, Jürgen Popp, Marco Andreana, Angelika Unterhuber
Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer
published pages: 2371, ISSN: 2076-3417, DOI: 10.3390/app8122371
Applied Sciences 8/12 2020-04-07
2018 Dominik Marti, Rikke N. Aasbjerg, Peter E. Andersen, Anders K. Hansen
MCmatlab: an open-source, user-friendly, MATLAB-integrated three-dimensional Monte Carlo light transport solver with heat diffusion and tissue damage
published pages: 1, ISSN: 1083-3668, DOI: 10.1117/1.jbo.23.12.121622
Journal of Biomedical Optics 23/12 2020-04-07
2019 Lara M. Wurster, Ronak N. Shah, Fabian Placzek, Simon Kretschmer, Michael Niederleithner, Laurin Ginner, Jason Ensher, Michael P. Minneman, Erich E. Hoover, Hans Zappe, Wolfgang Drexler, Rainer A. Leitgeb, Çağlar Ataman
Endoscopic optical coherence tomography angiography using a forward imaging piezo scanner probe
published pages: e201800382, ISSN: 1864-063X, DOI: 10.1002/jbio.201800382
Journal of Biophotonics 2020-04-07
2018 Eliana Cordero
In-vivo Raman spectroscopy: from basics to applications
published pages: 1, ISSN: 1083-3668, DOI: 10.1117/1.jbo.23.7.071210
Journal of Biomedical Optics 23/07 2020-04-07

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The information about "MIB" are provided by the European Opendata Portal: CORDIS opendata.

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