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FORCE SIGNED

Imaging the Force of Cancer

Total Cost €

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EC-Contrib. €

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Partnership

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Project "FORCE" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.force-imaging.org
 Total cost 7˙418˙116 €
 EC max contribution 5˙812˙631 € (78%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 2˙196˙560.00
2    UNIVERSITETET I OSLO NO (OSLO) participant 731˙000.00
3    THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL UK (LONDON) participant 631˙701.00
4    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 515˙000.00
5    UNIVERSITAET LEIPZIG DE (LEIPZIG) participant 503˙500.00
6    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 343˙100.00
7    SCREENCELL FR (SARCELLES) participant 322˙500.00
8    ASSISTANCE PUBLIQUE HOPITAUX DE PARIS FR (PARIS) participant 271˙020.00
9    CERMAKOVA IVA DE (CHEMNITZ) participant 150˙375.00
10    INTEGRATED TECHNOLOGIES LIMITED UK (ASHFORD) participant 98˙500.00
11    THE BRIGHAM AND WOMEN'S HOSPITAL INC US (BOSTON MA) participant 49˙375.00
12    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) participant 0.00
13    PHILIPS MEDICAL SYSTEMS NEDERLAND BV NL (BEST) participant 0.00
14    SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT FR (Chilly Mazarin) participant 0.00
15    UNIVERSITAT BASEL CH (BASEL) participant 0.00
16    UNIVERSITY OF NEW SOUTH WALES AU (SYDNEY) participant 0.00

Map

 Project objective

Cancer is the second leading cause of mortality in EU member states with ~90% of all cancer deaths caused by metastatic spread. Despite its significance, measuring metastatic potential as well as potential indicators of therapy efficacy remain unmet clinical challenges. Recently, it has been demonstrated in vitro, that aggressive metastatic cells pull on their surroundings suggesting that metastatic potential could be gauged by measuring the forces exert by tumours. Furthermore, many solid tumours show a significantly increased interstitial fluid pressure (IFP) which prevents the efficient uptake of therapeutic agents. As a result, a reduction in IFP is recognized as a hallmark of therapeutic efficacy. Currently, there is no non-invasive modality that can directly image these forces in vivo. Our objective is the non-invasive measurement of both IFP within tumours as well as the forces they exert on their surrounding environment. This will be used to predict a tumour’s metastatic potential and importantly, changes in these forces will be used to predict the therapeutic efficacy of drug therapy. To attain this goal, the biomechanical properties of the tumour and its neighbouring tissue will be measured via MR-elastography at various measured deformation states. Resultant images will be used to reconstruct images of the internal and external forces acting on the tumour. We call this novel imaging modality Magnetic Resonance Force (MRF) imaging . We will calibrate MRF via cell cultures and pre-clinical models, and then test the method in breast, liver, and brain cancer patients. Thereby, we will investigate whether MRF data can predict metastatic spread and measure IFP in patients. We will also investigate the potential to non-invasively modulate the force environment of cancer cells via externally applied shear forces with the aim of impacting cell motility and proliferation. This can provide novel mechanism for anticancer therapeutic agents via mechanotransduction.

 Deliverables

List of deliverables.
Report on clinical MRF protocol for breast Documents, reports 2020-04-07 20:29:54

Take a look to the deliverables list in detail:  detailed list of FORCE deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Daniel Fovargue, David Nordsletten, Ralph Sinkus
Stiffness reconstruction methods for MR elastography
published pages: e3935, ISSN: 0952-3480, DOI: 10.1002/nbm.3935
NMR in Biomedicine 31/10 2020-04-07
2019 Samuel Patz, Daniel Fovargue, Katharina Schregel, Navid Nazari, Miklos Palotai, Paul E. Barbone, Ben Fabry, Alexander Hammers, Sverre Holm, Sebastian Kozerke, David Nordsletten, Ralph Sinkus
Imaging localized neuronal activity at fast time scales through biomechanics
published pages: eaav3816, ISSN: 2375-2548, DOI: 10.1126/sciadv.aav3816
Science Advances 5/4 2020-04-07
2018 Daniel Fovargue, Sebastian Kozerke, Ralph Sinkus, David Nordsletten
Robust MR elastography stiffness quantification using a localized divergence free finite element reconstruction
published pages: 126-142, ISSN: 1361-8415, DOI: 10.1016/j.media.2017.12.005
Medical Image Analysis 44 2020-04-07
2016 Vikash Pandey and Sverre Holm
Linking the fractional derivative and the Lomnitz creep law to non-Newtonian time-varying viscosity
published pages: 32606, ISSN: 2470-0045, DOI: 10.1103/PhysRevE.94.032606
Physical Review E Vol. 94, Issue 3 2020-04-07
2016 Stefan Hetzer, Patric Birr, Andreas Fehlner, Sebastian Hirsch, Florian Dittmann, Eric Barnhill, Jürgen Braun, Ingolf Sack
Perfusion alters stiffness of deep gray matter
published pages: 0271678X1769153, ISSN: 0271-678X, DOI: 10.1177/0271678X17691530
Journal of Cerebral Blood Flow & Metabolism 2020-04-07
2018 Christian Guenthner, Sebastian Kozerke
Encoding and readout strategies in magnetic resonance elastography
published pages: e3919, ISSN: 0952-3480, DOI: 10.1002/nbm.3919
NMR in Biomedicine 31/10 2020-04-07
2018 Guenthner, Christian; Runge, Jurgen Henk; Sinkus, Ralph; Kozerke, Sebastian
Analysis and improvement of motion encoding in magnetic resonance elastography
published pages: , ISSN: 0952-3480, DOI: 10.5167/uzh-159366
Guenthner, Christian; Runge, Jurgen Henk; Sinkus, Ralph; Kozerke, Sebastian (2018). Analysis and improvement of motion encoding in magnetic resonance elastography. NMR in Biomedicine, 31(5):e3908. 1 2020-04-07
2017 Linda Oswald, Steffen Grosser, David M Smith, Josef A Käs
Jamming transitions in cancer
published pages: 483001, ISSN: 0022-3727, DOI: 10.1088/1361-6463/aa8e83
Journal of Physics D: Applied Physics 50/48 2020-04-07
2018 Claudia Tanja Mierke, Frank Sauer, Steffen Grosser, Stefanie Puder, Tony Fischer, Josef Alfons Käs
The two faces of enhanced stroma: Stroma acts as a tumor promoter and a steric obstacle
published pages: e3831, ISSN: 0952-3480, DOI: 10.1002/nbm.3831
NMR in Biomedicine 31/10 2020-04-07
2018 Jin Li, Konstantinos Zormpas-Petridis, Andreas Heindl, Jessica K.R. Boult, Craig Cummings, Jeffrey C. Bamber, Yinyin Yuan, Ralph Sinkus, Yann Jamin, Simon P. Robinson
Collagen is a major determinant of the viscoelasticity properties of stromal dense tumours: insights from pre-clinical MRE
published pages: \"Abstr #629\", ISSN: , DOI:
Proceedings of the Annual Meeting of the International Society for Magnetic Resonance in Medicine 2020-04-07
2018 Emma Reeves, Jin Li, Konstantinos Zormpas-Petridis, Andreas Heindl, Jessica K.R. Boult, Craig Cummings, Jeffrey C. Bamber, Yinyin Yuan, Ralph Sinkus, Yann Jamin, Simon P. Robinson
Stiffness, measured by magnetic resonance elastography (MRE), correlates with collagen content in stromal dense tumours
published pages: , ISSN: , DOI:
Forces in Cancer: interdisciplinary approaches in tumour mechanobiology 2020-04-07
2017 James P. B. O\'Connor, Eric O. Aboagye, Judith E. Adams, Hugo J. W. L. Aerts, Sally F. Barrington, Ambros J. Beer, Ronald Boellaard, Sarah E. Bohndiek, Michael Brady, Gina Brown, David L. Buckley, Thomas L. Chenevert, Laurence P. Clarke, Sandra Collette, Gary J. Cook, Nandita M. deSouza, John C. Dickson, Caroline Dive, Jeffrey L. Evelhoch, Corinne Faivre-Finn, Ferdia A. Gallagher, Fiona J. Gilbert, Robert J. Gillies, Vicky Goh, John R. Griffiths, Ashley M. Groves, Steve Halligan, Adrian L. Harris, David J. Hawkes, Otto S. Hoekstra, Erich P. Huang, Brian F. Hutton, Edward F. Jackson, Gordon C. Jayson, Andrew Jones, Dow-Mu Koh, Denis Lacombe, Philippe Lambin, Nathalie Lassau, Martin O. Leach, Ting-Yim Lee, Edward L. Leen, Jason S. Lewis, Yan Liu, Mark F. Lythgoe, Prakash Manoharan, Ross J. Maxwell, Kenneth A. Miles, Bruno Morgan, Steve Morris, Tony Ng, Anwar R. Padhani, Geoff J. M. Parker, Mike Partridge, Arvind P. Pathak, Andrew C. Peet, Shonit Punwani, Andrew R. Reynolds, Simon P. Robinson, Lalitha K. Shankar, Ricky A. Sharma, Dmitry Soloviev, Sigrid Stroobants, Daniel C. Sullivan, Stuart A. Taylor, Paul S. Tofts, Gillian M. Tozer, Marcel van Herk, Simon Walker-Samuel, James Wason, Kaye J. Williams, Paul Workman, Thomas E. Yankeelov, Kevin M. Brindle, Lisa M. McShane, Alan Jackson, John C. Waterton
Imaging biomarker roadmap for cancer studies
published pages: 169-186, ISSN: 1759-4774, DOI: 10.1038/nrclinonc.2016.162
Nature Reviews Clinical Oncology 14/3 2020-04-07

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