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Innovative Dermatology Healthcare based on Label-Free Spectral Optoacoustic Mesoscopy

Total Cost €


EC-Contrib. €






 INNODERM project word cloud

Explore the words cloud of the INNODERM project. It provides you a very rough idea of what is the project "INNODERM" about.

smes    mesoscopy    ultrasound    ithera    resolved    inside    centimetres    validate    biedermann    grant    barriers    paradigm    proof    commercialized    animal    tum    free    ntziachristos    innovative    brings    millimetres    physiological    dimensional    capacity    leader    fast    ranging    depths    shift    prototype    deep    termed    scattering    costanzo    suites    handheld    cell    viability    tomography    5mm    care    rsom    microscopy    mesoscopic    small    multispectral    imaging    improves    photon    successful    optic    scalable    dermatologists    rayfos    dramatically    2008    tissues    macroscopy    single    2013    sonaxis    resolution    contrast    business    originally    absorption    skin    msot    conventional    diagnosis    photonic    medical    sur    raster    innoderm    award    device    demonstrated    technologies    disease    revolution    point    erc    optoacoustic    prof    acoustic    optical    scan    anatomical    insensitive    sold    spectrally    parallel    market    dermatology    monitoring    molecular    world    recommendations    bio    label    substantiating    scalability    economic    tissue    portable   

Project "INNODERM" data sheet

The following table provides information about the project.


Organization address
address: Arcisstrasse 21
postcode: 80333

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 4˙595˙125 €
 EC max contribution 3˙869˙879 € (84%)
 Programme 1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
 Code Call H2020-ICT-2015
 Funding Scheme IA
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2021-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
2    HUMANITAS UNIVERSITY IT (PIEVE EMANUELE) participant 745˙288.00
3    ITHERA MEDICAL GMBH DE (MUNCHEN) participant 724˙868.00
4    RAYFOS LTD UK (BASINGSTOKE) participant 496˙133.00
5    SONAXIS SA FR (BESANCON) participant 471˙238.00


 Project objective

Multispectral Optoacoustic Tomography (MSOT) brings a revolution to bio-optical imaging. Being insensitive to photon scattering, MSOT dramatically improves upon conventional bio-optic barriers by enabling (1) three-dimensional high-resolution optical imaging deep inside tissues (several millimetres to centimetres), by (2) high-scalability, ranging from optical-resolution microscopy to acoustic-resolution optical mesoscopy and macroscopy and by (3) novel label-free anatomical, physiological and molecular contrast at the tissue and single-cell-level, based on spectrally-resolved optical absorption. MSOT, originally supported by an ERC Advanced Award (2008) (TUM: Prof. Ntziachristos), is already commercialized by iThera Medical for macroscopy with systems sold around the world for small animal imaging. In parallel, ERC MSOT funding developed a mesoscopic implementation, termed raster-scan optoacoustic mesoscopy (RSOM), which has demonstrated innovative imaging capacity at 1-5mm depths. Driven by leading dermatologists (TUM: Prof. Biedermann; SUR: Prof. Costanzo) and market leader SMEs in optoacoustic and ultrasound technology (iThera, Rayfos, Sonaxis), INNODERM will design and prototype a handheld, portable, scalable, label-free RSOM device for point-of care dermatology applications, based on recommendations developed under an ERC proof of concept grant (2013) on MSOT. INNODERM brings together key photonic & ultrasound technologies and will validate the technical and economic viability of RSOM in dermatology suites for fast diagnosis and skin disease monitoring. RSOM can go beyond the abilities of current optical or optoacoustic devices and offer a paradigm shift in dermatology imaging, substantiating successful business cases.


List of deliverables.
Functioning RSOM2 prototype Other 2019-09-04 15:23:38
Final single element transducers for RSOM with low noise amplification Other 2019-09-04 15:23:38
Report or publication on algorithmic acceleration Documents, reports 2019-09-04 15:23:38
Report on LiNBO3 vs PZT element transducers Documents, reports 2019-09-04 15:23:38
Report or publication on read-electronics speeds and efficiency Documents, reports 2019-09-04 15:23:38
Report on performance of RSOM2 Documents, reports 2019-09-04 15:23:38
Update, communication kit Websites, patent fillings, videos etc. 2019-09-04 15:23:38
Press release, project launch Websites, patent fillings, videos etc. 2019-09-04 15:23:38
First communication kit Websites, patent fillings, videos etc. 2019-09-04 15:23:38
Project web site Websites, patent fillings, videos etc. 2019-09-04 15:23:38

Take a look to the deliverables list in detail:  detailed list of INNODERM deliverables.


year authors and title journal last update
List of publications.
2017 Mathias Schwarz, Natalie Garzorz-Stark, Kilian Eyerich, Juan Aguirre, Vasilis Ntziachristos
Motion correction in optoacoustic mesoscopy
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-11277-y
Scientific Reports 7/1 2019-09-04
2017 Juan Aguirre, Mathias Schwarz, Natalie Garzorz, Murad Omar, Andreas Buehler, Kilian Eyerich, Vasilis Ntziachristos
Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy
published pages: 68, ISSN: 2157-846X, DOI: 10.1038/s41551-017-0068
Nature Biomedical Engineering 1/5 2019-09-04
2017 Alessandra Narcisi, Rebecca Favaro, Antonio Costanzo
Diagnostic imaging: Listening in to skin disease
published pages: 76, ISSN: 2157-846X, DOI: 10.1038/s41551-017-0076
Nature Biomedical Engineering 1/5 2019-09-04
2017 M. Talamonti, M. Galluzzo, J.M. van den Reek, E.M. de Jong, J.L.W. Lambert, P. Malagoli, L. Bianchi, A. Costanzo
Role of the HLA-C*06 allele in clinical response to ustekinumab: evidence from real life in a large cohort of European patients
published pages: 489-496, ISSN: 0007-0963, DOI: 10.1111/bjd.15387
British Journal of Dermatology 177/2 2019-09-04
2017 Mathias Schwarz, Dominik Soliman, Murad Omar, Andreas Buehler, Saak V. Ovsepian, Juan Aguirre, Vasilis Ntziachristos
Optoacoustic Dermoscopy of the Human Skin: Tuning Excitation Energy for Optimal Detection Bandwidth with Fast and Deep Imaging in vivo
published pages: 1-1, ISSN: 0278-0062, DOI: 10.1109/TMI.2017.2664142
IEEE Transactions on Medical Imaging 2019-09-04
2019 Juan Aguirre, Andrei Berezhnoi, Hailong He, Mathias Schwarz, Benedikt Hindelang, Murad Omar, Vasilis Ntziachristos
Motion quantification and automated correction in clinical RSOM
published pages: 1-1, ISSN: 0278-0062, DOI: 10.1109/tmi.2018.2883154
IEEE Transactions on Medical Imaging 2019-09-04
2019 Murad Omar, Juan Aguirre, Vasilis Ntziachristos
Optoacoustic mesoscopy for biomedicine
published pages: , ISSN: 2157-846X, DOI: 10.1038/s41551-019-0377-4
Nature Biomedical Engineering 2019-09-04
2018 Antonios Stylogiannis, Ludwig Prade, Andreas Buehler, Juan Aguirre, George Sergiadis, Vasilis Ntziachristos
Continuous wave laser diodes enable fast optoacoustic imaging
published pages: 31-38, ISSN: 2213-5979, DOI: 10.1016/j.pacs.2017.12.002
Photoacoustics 9 2019-09-04
2018 B. Hindelang, J. Aguirre, M. Schwarz, A. Berezhnoi, K. Eyerich, V. Ntziachristos, T. Biedermann, U. Darsow
Non-invasive imaging in dermatology and the unique potential of Raster-Scan Optoacoustic Mesoscopy (RSOM)
published pages: , ISSN: 0926-9959, DOI: 10.1111/jdv.15342
Journal of the European Academy of Dermatology and Venereology 2019-09-04
2018 Andrei Berezhnoi, Mathias Schwarz, Andreas Buehler, Saak V. Ovsepian, Juan Aguirre, Vasilis Ntziachristos
Assessing hyperthermia-induced vasodilation in human skin in vivo using optoacoustic mesoscopy
published pages: e201700359, ISSN: 1864-063X, DOI: 10.1002/jbio.201700359
Journal of Biophotonics 11/11 2019-09-04
2018 J. Aguirre, B. Hindelang, Andrei Berezhnoi, U. Darsow, F. Lauffer, K. Eyerich, T. Biedermann, V. Ntziachristos
Assessing nailfold microvascular structure with ultra-wideband raster-scan optoacoustic mesoscopy
published pages: 31-37, ISSN: 2213-5979, DOI: 10.1016/j.pacs.2018.02.002
Photoacoustics 10 2019-09-04

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