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PELICO SIGNED

Peptidomimetics with photocontrolled biological activity

Total Cost €

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EC-Contrib. €

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Partnership

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Project "PELICO" data sheet

The following table provides information about the project.

Coordinator
ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE 

Organization address
address: 78 CHERVONOTKATSKA STR.
city: KYIV
postcode: 2094
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ukraine [UA]
 Project website http://pelico.org/
 Total cost 688˙500 €
 EC max contribution 688˙500 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2015
 Funding Scheme MSCA-RISE
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE UA (KYIV) coordinator 409˙500.00
2    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 108˙000.00
3    LATVIJAS ORGANISKAS SINTEZES INSTITUTS LV (RIGA) participant 103˙500.00
4    KARLSRUHER INSTITUT FUER TECHNOLOGIE DE (KARLSRUHE) participant 67˙500.00

Map

 Project objective

The expertise, resources and specific knowledge of all participating parties will be combined to achieve a breakthrough in design, synthesis and application of peptide analogues (peptidomimetics) possessing photo-controlled biological activities, with special emphasis on anti-microbial and anti-cancer activities. The main idea behind the Project consists in chemical incorporation of artificial photo-controllable building blocks into known biologically active peptides by replacing their natural building blocks – the amino acid residues. Such a modification would provide photocontrolled peptidomimetics which can reversibly change their structure between two different photo-forms upon irradiation with light of different wavelength. The participating parties possess general know-how for design of the peptidomimetics which can exist in two photo-forms, biologically active and inactive ones, reversibly interconvertible by light of different wavelength. This opens a possibility to convert inactive peptidomimetics to active compounds by irradiation with physiologically benign light directly in tissues with very high spatiotemporal precision and can be a fundamental basis of new therapeutic strategies. The research staff exchange and other activities planned under the Project will be dedicated to accomplish four complementary work packages: (i) carrying out pharmacokinetic and toxicity studies of the photocontrolled peptidomimetics synthesized by the parties previously; (ii) evaluation of novel photocontrolled building block chemotypes for their compatibility with peptides; (iii) creation of new photocontrolled peptidomimetics, especially based on the novel building blocks and the know-how developed by the parties (e.g. using “stapled peptides” technology); (iv) multidisciplinary training of the researchers whose future work will be aimed at further development of the most advanced photocontrolled peptidomimetics as drugs suitable for photodynamic therapy.

 Deliverables

List of deliverables.
Reports on biological activity studies Documents, reports 2020-03-20 15:18:12
Novel photocontrollable building blocks Other 2020-03-20 15:18:12
manuscript 4 Documents, reports 2020-03-20 15:18:12
Manuscript 2 Documents, reports 2020-03-20 15:18:12
Manuscript 3 Documents, reports 2020-03-20 15:18:12
Manuscript 1 Documents, reports 2020-03-20 15:18:12
Project web-site Websites, patent fillings, videos etc. 2020-03-20 15:18:12

Take a look to the deliverables list in detail:  detailed list of PELICO deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Oleg Babii, Sergii Afonin, Tim Schober, Liudmyla V Garmanchuk, Liudmyla I Ostapchenko, Volodymyr Yurchenko, Sergey Zozulya, Oleksandr Tarasov, Iryna Pishel, Anne S Ulrich, Igor V Komarov
Peptide drugs for photopharmacology: how much of a safety advantage can be gained by photocontrol?
published pages: , ISSN: 2631-3316, DOI: 10.4155/fdd-2019-0033
Future Drug Discovery 2020-03-20
2020 Sergii Afonin, Oleg Babii, Aline Reuter, Volker Middel, Masanari Takamiya, Uwe Strähle, Igor V Komarov, Anne S Ulrich
Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos
published pages: 39-49, ISSN: 1860-5397, DOI: 10.3762/bjoc.16.6
Beilstein Journal of Organic Chemistry 16 2020-03-20
2019 Tim Schober, Ilona Wehl, Sergii Afonin, Oleg Babii, Anna Iampolska, Ute Schepers, Igor V. Komarov, Anne S. Ulrich
Controlling the Uptake of Diarylethene‐Based Cell‐Penetrating Peptides into Cells Using Light
published pages: , ISSN: 2367-0932, DOI: 10.1002/cptc.201900019
ChemPhotoChem 2020-03-20
2018 Alexander V. Strizhak, Krishna Sharma, Oleg Babii, Sergii Afonin, Anne S. Ulrich, Igor V. Komarov, David R. Spring
Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking
published pages: , ISSN: 1477-0520, DOI: 10.1039/c8ob02428f
Organic & Biomolecular Chemistry 2020-03-20
2018 Oleg Babii, Sergii Afonin, Aleksandr Yu. Ishchenko, Tim Schober, Anatoliy O. Negelia, Ganna M. Tolstanova, Liudmyla V. Garmanchuk, Liudmyla I. Ostapchenko, Igor V. Komarov, Anne S. Ulrich
Structure–Activity Relationships of Photoswitchable Diarylethene-Based β-Hairpin Peptides as Membranolytic Antimicrobial and Anticancer Agents
published pages: 10793-10813, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.8b01428
Journal of Medicinal Chemistry 61/23 2020-03-20
2017 Oleg Babii, Sergii Afonin, Tim Schober, Igor V. Komarov, Anne S. Ulrich
Flexibility vs rigidity of amphipathic peptide conjugates when interacting with lipid bilayers
published pages: 2505-2515, ISSN: 0005-2736, DOI: 10.1016/j.bbamem.2017.09.021
Biochimica et Biophysica Acta (BBA) - Biomembranes 1859/12 2020-03-20

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The information about "PELICO" are provided by the European Opendata Portal: CORDIS opendata.

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