Bi-Stretch-4-Biomed SIGNED
BIaxial STRETCHing of PLLA-WS2 nanocomposites FOR thinner and stronger BIOMEDical scaffolds
Total Cost €
0EC-Contrib. €
0Partnership
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Project "Bi-Stretch-4-Biomed" data sheet
The following table provides information about the project.
| Coordinator |
AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Project website | http://www.bi-stretch-4-biomed.com |
| Total cost | 400˙500 € |
| EC max contribution | 342˙000 € (85%) |
| Programme |
1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge) |
| Code Call | H2020-MSCA-RISE-2015 |
| Funding Scheme | MSCA-RISE |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-02-01 to 2020-01-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE | IT (ROMA) | coordinator | 139˙500.00 |
| 2 | THE QUEEN'S UNIVERSITY OF BELFAST | UK (BELFAST) | participant | 135˙000.00 |
| 3 | THE UNIVERSITY OF WARWICK | UK (COVENTRY) | participant | 67˙500.00 |
| 4 | CALIFORNIA INSTITUTE OF TECHNOLOGYCORP | US (PASADENA) | partner | 0.00 |
Map
Project objective
New materials are now opening clinical treatments in which a temporary scaffold is used to support regeneration of healthy tissue. The specific need that inspires our research is for thinner and stronger bioresorbable vascular scaffolds (BVS) for coronary heart disease. BVS are poised to replace metal stents due to the excellent clinical outcomes: beyond keeping the vessel open during the first six months after surgery, the BVS leaves behind a healthy blood vessel after the scaffold is gone, being completely absorbed by the body approximately two years after surgery. The material that has achieved clinical approval for BVS is poly(L-lactic acid), PLLA. It is not as strong and stiff as metals, so the scaffold is three times thicker than the metal stents, making it more difficult for surgeons to move through arteries to reach the site of the lesion. Thinner Scaffolds that can be seen by x-ray imaging during surgery would facilitate adoption of the technology and benefit thousands of patients in the EU and US. The proposed Action will provide the fundamental understanding needed to reinforce PLLA by tungsten disulphide (WS2) nanotubes to achieve both the strength and x-ray opacity needed. Improving materials for BVS requires an interdisciplinary approach by materials science, polymer processing, and bioengineering. The proposed Action will connect EU scientists with a polymer scientist at Caltech in the US who has specialized knowledge of PLLA BVS and the relevant structure-processing-property relationships (Kornfield). European scientists bring expertise in WS2 nanotubes that are powerful additives for enhancing polymer properties (Di Luccio), compounding polymers with nanotubes (McNally), biaxial stretching to induce strength and orientation in polymers (Menary), multiscale modeling to connect nanoscale to continuum scale (Figiel), multimethod characterization of structure in nanocomposites (Schiller) and the response of cells to nanoparticles (Kornfield).
Deliverables
| Publication of the website | Websites, patent fillings, videos etc. | 2019-07-22 09:24:17 |
Take a look to the deliverables list in detail: detailed list of Bi-Stretch-4-Biomed deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
R.W. Blair, N.J. Dunne, A.B. Lennon, G.H. Menary Processing-property relationships of biaxially stretched poly(L-lactic acid) sheet for application in coronary stents published pages: 113-121, ISSN: 1751-6161, DOI: 10.1016/j.jmbbm.2018.06.017 |
Journal of the Mechanical Behavior of Biomedical Materials 86 | 2020-01-30 |
| 2019 |
Ross W. Blair, Nicholas J. Dunne, Alex B. Lennon, Gary H. Menary Multi-objective optimisation of material properties and strut geometry for poly(L-lactic acid) coronary stents using response surface methodology published pages: e0218768, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0218768 |
PLOS ONE 14/8 | 2020-01-30 |
| 2019 |
R.W. Blair, N.J. Dunne, A.B. Lennon, G.H. Menary Characterisation and constitutive modelling of biaxially stretched poly(L-lactic acid) sheet for application in coronary stents published pages: 346-354, ISSN: 1751-6161, DOI: 10.1016/j.jmbbm.2019.05.039 |
Journal of the Mechanical Behavior of Biomedical Materials 97 | 2020-01-28 |
| 2017 |
E. E. Ruiz Bello, K. Ramachandran, T. Di Luccio and J. A. Kornfield Investigating Nanocomposites od Polylactide (PLA) and Tungsten Disulfide (WS2) for Thinner, Radio-Opaque Bioresorbable Vascular Scaffolds (BVS) published pages: , ISSN: , DOI: |
2019-07-22 | |
| 2017 |
E. E. Ruiz Bello, K. Ramachandran, T. Di Luccio and J. A. Kornfield Investigating Nanocomposites od Polylactide (PLA) and Tungsten Disulfide (WS2) for Thinner, Radio-Opaque Bioresorbable Vascular Scaffolds (BVS) published pages: , ISSN: , DOI: |
2019-07-22 | |
| 2017 |
T. Di Luccio, K. Ramachandran, C. Borriello, F. Di Benedetto, T. L. Schiller, L. Tammaro, F. Villani, J. A. Kornfield Enabling Thinner, Radio-Opaque Bioresorbable Vascular Scaffolds Using Biocompatible Nanocomposites of Poly (L-lactide) and Tungsten Disulfide Nanotubes published pages: , ISSN: , DOI: |
2017 APS/CNM User Meeting, Argonne National Laboratories, May 8-11 (2017) | 2019-07-22 |
| 2018 |
T. Di Luccio, K. Ramachandran, R. Miscioscia, G. De
Filippo, G. Pandolfi, and J. A. Kornfield In situ Synchrotron X-ray Scattering during Extensional Flow Induced Crystallization of PLLA Enabled by Tube Expansion Deformation published pages: , ISSN: , DOI: |
3rd Joint AIC-SILS Conference - Rome, June 25-28, 2018 | 2019-07-22 |
| 2018 |
Tiziana Di Luccio, Karthik Ramachandran, Zach Zixuan Shao, Loredana Tammaro, Carmela Borriello, Fausta Loffredo, Fulvia Villani, Francesca Di Benedetto, Sandy Leung, Tony McNally, David Boyd, Julie Kornfield Impact of Tungsten Disulfide Nanotubes on the crystallization of poly (l-lactide) for thinner and stronger bioresorbable vascular scaffolds (BVS) published pages: , ISSN: , DOI: |
Bulletin of the American Physical Society | 2019-07-22 |
| 2016 |
H. Wei, G. Menary Finite element analysis for the manufacture of angioplasty balloons published pages: , ISSN: , DOI: |
Proceedings of the 22nd Bioengineering Conference in Ireland | 2019-07-22 |
| 2018 |
Blair, R., Dunne, N., Lennon, A. and Menary, G Parametric Optimisation of a Stretch Blow Moulded Poly(L-lactic acid) Stent published pages: , ISSN: , DOI: |
Bioengineering in Ireland 2018 Programme | 2019-07-22 |
| 2017 |
Blair, R., Dunne, N., Lennon, A. and Menary, G Effect of Processing History on the Mechanical Behaviour of PLLA Stents published pages: , ISSN: , DOI: |
Bioengineering in Ireland (23) Programme | 2019-07-22 |
| 2017 |
H. Wei, G. Menary Modelling Mechanical Behaviour of Poly(L-lactic acid) for the Manufacture of Bioresorbable Vascular Scaffolds published pages: , ISSN: , DOI: |
Proceedings of the 23rd Bioengineering in Ireland | 2019-07-22 |
| 2017 |
Huidong Wei, Gary Menary Investigation on thermomechanical properties of poly (l-lactic acid) for the stretch blow moulding process of bioresorbable vascular scaffold published pages: 60002, ISSN: , DOI: 10.1063/1.5008065 |
AIP Conference Proceedings volume 1892 | 2019-07-22 |
| 2017 |
H. Wei, G. Menary, S. Yan Modelling Mechanical Behaviour of Amorphous Poly (L-Lactic Acid) under Biaxial Stretch at Temperatures above Glass Transition published pages: , ISSN: , DOI: |
Proceedings of SPE ANTEC 2017 | 2019-07-22 |
| 2018 |
Karthik Ramachandran, Riccardo Miscioscia, Giovanni Filippo, Giuseppe Pandolfi, Tiziana Di Luccio, Julia Kornfield Tube Expansion Deformation Enables In Situ Synchrotron X-ray Scattering Measurements during Extensional Flow-Induced Crystallization of Poly l-Lactide Near the Glass Transition published pages: 288, ISSN: 2073-4360, DOI: 10.3390/polym10030288 |
Polymers 10/3 | 2019-07-22 |
| 2018 |
T. Di Luccio, K. Ramachandran, R. Miscioscia, G. De
Filippo, G. Pandolfi, and J. A. Kornfield In situ Synchrotron X-ray Scattering during Extensional Flow Induced Crystallization of PLLA Enabled by Tube Expansion Deformation published pages: , ISSN: , DOI: |
3rd Joint AIC-SILS Conference - Rome, June 25-28, 2018 | 2019-07-22 |
| 2017 |
Blair, R., Dunne, N., Lennon, A. and Menary, G Parametric Study to Evaluate the Effect of Strut Geometry on PLLA Coronary Stent Recoil published pages: 648–658, ISSN: , DOI: |
SIMULIA Science in the Age of Experience - Proceedings 2017 | 2019-07-22 |
| 2018 |
Kharmen Billimoria, Ellen L. Heeley, Nathan Parsons, Åukasz Figiel An investigation into the crystalline morphology transitions in poly-L- lactic acid (PLLA) under uniaxial deformation in the quasi-solid-state regime published pages: , ISSN: 0014-3057, DOI: 10.1016/j.eurpolymj.2018.01.031 |
European Polymer Journal | 2019-07-22 |
| 2016 |
Blair, R., Dunne, N., Lennon, A. and Menary, G Investigating Biomechanics of Bioresorbable Coronary Stents published pages: 161, ISSN: , DOI: |
Bioengineering in Ireland (22) Book of Abstracts | 2019-07-22 |
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