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Bi-Stretch-4-Biomed SIGNED

BIaxial STRETCHing of PLLA-WS2 nanocomposites FOR thinner and stronger BIOMEDical scaffolds

Total Cost €

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EC-Contrib. €

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 Outcomes and results

 Bi-Stretch-4-Biomed project word cloud

Explore the words cloud of the Bi-Stretch-4-Biomed project. It provides you a very rough idea of what is the project "Bi-Stretch-4-Biomed" about.

acid    schiller    strength    months    opening    plla    multiscale    inspires    bioresorbable    patients    completely    tissue    lesion    ws2    benefit    surgery    nanoparticles    mcnally    menary    site    six    polymers    relationships    move    compounding    thicker    poly    scaffold    expertise    imaging    lactic    characterization    heart    disulphide    bioengineering    healthy    arteries    specialized    thousands    nanoscale    stretching    cells    excellent    clinical    interdisciplinary    surgeons    new    body    thinner    temporary    leaves    fundamental    stiff    induce    stronger    gone    opacity    approval    action    additives    powerful    vessel    scientists    multimethod    structure    metal    difficult    kornfield    blood    nanocomposites    reinforce    replace    property    caltech    coronary    scaffolds    polymer    vascular    material    adoption    continuum    keeping    first    orientation    stents    ray    outcomes    treatments    connect    approximately    regeneration    bvs    times    luccio    biaxial    science    disease    modeling    materials    figiel    metals    poised    di    absorbed    tungsten    nanotubes    scientist   

Project "Bi-Stretch-4-Biomed" data sheet

The following table provides information about the project.

Coordinator		 AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE 

Organization address
address: LUNGOTEVERE GRANDE AMMIRAGLIO THAON DI REVEL 76
city: ROMA
postcode: 196
website: http://www.enea.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Italy [IT]
 Project website http://www.bi-stretch-4-biomed.com
 Total cost 400˙500 €
 EC max contribution 342˙000 € (85%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2015
 Funding Scheme MSCA-RISE
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2020-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE IT (ROMA) coordinator 139˙500.00
2    THE QUEEN'S UNIVERSITY OF BELFAST UK (BELFAST) participant 135˙000.00
3    THE UNIVERSITY OF WARWICK UK (COVENTRY) participant 67˙500.00
4    CALIFORNIA INSTITUTE OF TECHNOLOGYCORP US (PASADENA) partner 0.00

Map

 Project objective

New materials are now opening clinical treatments in which a temporary scaffold is used to support regeneration of healthy tissue. The specific need that inspires our research is for thinner and stronger bioresorbable vascular scaffolds (BVS) for coronary heart disease. BVS are poised to replace metal stents due to the excellent clinical outcomes: beyond keeping the vessel open during the first six months after surgery, the BVS leaves behind a healthy blood vessel after the scaffold is gone, being completely absorbed by the body approximately two years after surgery. The material that has achieved clinical approval for BVS is poly(L-lactic acid), PLLA. It is not as strong and stiff as metals, so the scaffold is three times thicker than the metal stents, making it more difficult for surgeons to move through arteries to reach the site of the lesion. Thinner Scaffolds that can be seen by x-ray imaging during surgery would facilitate adoption of the technology and benefit thousands of patients in the EU and US. The proposed Action will provide the fundamental understanding needed to reinforce PLLA by tungsten disulphide (WS2) nanotubes to achieve both the strength and x-ray opacity needed. Improving materials for BVS requires an interdisciplinary approach by materials science, polymer processing, and bioengineering. The proposed Action will connect EU scientists with a polymer scientist at Caltech in the US who has specialized knowledge of PLLA BVS and the relevant structure-processing-property relationships (Kornfield). European scientists bring expertise in WS2 nanotubes that are powerful additives for enhancing polymer properties (Di Luccio), compounding polymers with nanotubes (McNally), biaxial stretching to induce strength and orientation in polymers (Menary), multiscale modeling to connect nanoscale to continuum scale (Figiel), multimethod characterization of structure in nanocomposites (Schiller) and the response of cells to nanoparticles (Kornfield).

 Deliverables

List of deliverables.
Publication of the website Websites, patent fillings, videos etc. 2019-07-22 09:24:17

Take a look to the deliverables list in detail:  detailed list of Bi-Stretch-4-Biomed deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 R.W. Blair, N.J. Dunne, A.B. Lennon, G.H. Menary
Processing-property relationships of biaxially stretched poly(L-lactic acid) sheet for application in coronary stents
published pages: 113-121, ISSN: 1751-6161, DOI: 10.1016/j.jmbbm.2018.06.017 		Journal of the Mechanical Behavior of Biomedical Materials 86 2020-01-30
2019 Ross W. Blair, Nicholas J. Dunne, Alex B. Lennon, Gary H. Menary
Multi-objective optimisation of material properties and strut geometry for poly(L-lactic acid) coronary stents using response surface methodology
published pages: e0218768, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0218768 		PLOS ONE 14/8 2020-01-30
2019 R.W. Blair, N.J. Dunne, A.B. Lennon, G.H. Menary
Characterisation and constitutive modelling of biaxially stretched poly(L-lactic acid) sheet for application in coronary stents
published pages: 346-354, ISSN: 1751-6161, DOI: 10.1016/j.jmbbm.2019.05.039 		Journal of the Mechanical Behavior of Biomedical Materials 97 2020-01-28
2017 E. E. Ruiz Bello, K. Ramachandran, T. Di Luccio and J. A. Kornfield
Investigating Nanocomposites od Polylactide (PLA) and Tungsten Disulfide (WS2) for Thinner, Radio-Opaque Bioresorbable Vascular Scaffolds (BVS)
published pages: , ISSN: , DOI: 		2019-07-22
2017 E. E. Ruiz Bello, K. Ramachandran, T. Di Luccio and J. A. Kornfield
Investigating Nanocomposites od Polylactide (PLA) and Tungsten Disulfide (WS2) for Thinner, Radio-Opaque Bioresorbable Vascular Scaffolds (BVS)
published pages: , ISSN: , DOI: 		2019-07-22
2017 T. Di Luccio, K. Ramachandran, C. Borriello, F. Di Benedetto, T. L. Schiller, L. Tammaro, F. Villani, J. A. Kornfield
Enabling Thinner, Radio-Opaque Bioresorbable Vascular Scaffolds Using Biocompatible Nanocomposites of Poly (L-lactide) and Tungsten Disulfide Nanotubes
published pages: , ISSN: , DOI: 		2017 APS/CNM User Meeting, Argonne National Laboratories, May 8-11 (2017) 2019-07-22
2018 T. Di Luccio, K. Ramachandran, R. Miscioscia, G. De Filippo, G. Pandolfi, and J. A. Kornfield
In situ Synchrotron X-ray Scattering during Extensional Flow Induced Crystallization of PLLA Enabled by Tube Expansion Deformation
published pages: , ISSN: , DOI: 		3rd Joint AIC-SILS Conference - Rome, June 25-28, 2018 2019-07-22
2018 Tiziana Di Luccio, Karthik Ramachandran, Zach Zixuan Shao, Loredana Tammaro, Carmela Borriello, Fausta Loffredo, Fulvia Villani, Francesca Di Benedetto, Sandy Leung, Tony McNally, David Boyd, Julie Kornfield
Impact of Tungsten Disulfide Nanotubes on the crystallization of poly (l-lactide) for thinner and stronger bioresorbable vascular scaffolds (BVS)
published pages: , ISSN: , DOI: 		Bulletin of the American Physical Society 2019-07-22
2016 H. Wei, G. Menary
Finite element analysis for the manufacture of angioplasty balloons
published pages: , ISSN: , DOI: 		Proceedings of the 22nd Bioengineering Conference in Ireland 2019-07-22
2018 Blair, R., Dunne, N., Lennon, A. and Menary, G
Parametric Optimisation of a Stretch Blow Moulded Poly(L-lactic acid) Stent
published pages: , ISSN: , DOI: 		Bioengineering in Ireland 2018 Programme 2019-07-22
2017 Blair, R., Dunne, N., Lennon, A. and Menary, G
Effect of Processing History on the Mechanical Behaviour of PLLA Stents
published pages: , ISSN: , DOI: 		Bioengineering in Ireland (23) Programme 2019-07-22
2017 H. Wei, G. Menary
Modelling Mechanical Behaviour of Poly(L-lactic acid) for the Manufacture of Bioresorbable Vascular Scaffolds
published pages: , ISSN: , DOI: 		Proceedings of the 23rd Bioengineering in Ireland 2019-07-22
2017 Huidong Wei, Gary Menary
Investigation on thermomechanical properties of poly (l-lactic acid) for the stretch blow moulding process of bioresorbable vascular scaffold
published pages: 60002, ISSN: , DOI: 10.1063/1.5008065 		AIP Conference Proceedings volume 1892 2019-07-22
2017 H. Wei, G. Menary, S. Yan
Modelling Mechanical Behaviour of Amorphous Poly (L-Lactic Acid) under Biaxial Stretch at Temperatures above Glass Transition
published pages: , ISSN: , DOI: 		Proceedings of SPE ANTEC 2017 2019-07-22
2018 Karthik Ramachandran, Riccardo Miscioscia, Giovanni Filippo, Giuseppe Pandolfi, Tiziana Di Luccio, Julia Kornfield
Tube Expansion Deformation Enables In Situ Synchrotron X-ray Scattering Measurements during Extensional Flow-Induced Crystallization of Poly l-Lactide Near the Glass Transition
published pages: 288, ISSN: 2073-4360, DOI: 10.3390/polym10030288 		Polymers 10/3 2019-07-22
2018 T. Di Luccio, K. Ramachandran, R. Miscioscia, G. De Filippo, G. Pandolfi, and J. A. Kornfield
In situ Synchrotron X-ray Scattering during Extensional Flow Induced Crystallization of PLLA Enabled by Tube Expansion Deformation
published pages: , ISSN: , DOI: 		3rd Joint AIC-SILS Conference - Rome, June 25-28, 2018 2019-07-22
2017 Blair, R., Dunne, N., Lennon, A. and Menary, G
Parametric Study to Evaluate the Effect of Strut Geometry on PLLA Coronary Stent Recoil
published pages: 648–658, ISSN: , DOI: 		SIMULIA Science in the Age of Experience - Proceedings 2017 2019-07-22
2018 Kharmen Billimoria, Ellen L. Heeley, Nathan Parsons, Łukasz Figiel
An investigation into the crystalline morphology transitions in poly-L- lactic acid (PLLA) under uniaxial deformation in the quasi-solid-state regime
published pages: , ISSN: 0014-3057, DOI: 10.1016/j.eurpolymj.2018.01.031 		European Polymer Journal 2019-07-22
2016 Blair, R., Dunne, N., Lennon, A. and Menary, G
Investigating Biomechanics of Bioresorbable Coronary Stents
published pages: 161, ISSN: , DOI: 		Bioengineering in Ireland (22) Book of Abstracts 2019-07-22

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