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ROMB SIGNED

Retina Organoid Mechanobiology

Total Cost €

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EC-Contrib. €

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Partnership

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 ROMB project word cloud

Explore the words cloud of the ROMB project. It provides you a very rough idea of what is the project "ROMB" about.

mechanobiology    physical    physiological    opens    players    me    limited    techniques    regulating    cellular    abnormalities    signals    organoid    disease    alzheimer    signatures    gene    mouse    quantified    ball    turn    microscopy    mechanical    model    retinas    promises    diseases    accordingly    suited    neuronal    behavior    interactions    app    hallmark    uniquely    genetic    hereby    breakthrough    exists    functional    mechanics    aggregates    actuators    door    mutation    neuroscience    droplets    environment    function    multifaceted    lightsheet    stem    cell    manipulate    organization    mechanically    tailoring    disciplinary    readout    modeling    carries    prevented    linked    onset    guide    shape    recorded    first    physicists    court    biophysical    plan    basic    variations    vitro    glaucoma    peptide    building    detect    organoids    bioengineers    posts    3d    establishment    quantify    mimic    organogenesis    reveal    final    ferrofluid    cells    cross    engineering    tackle    revealed    introduces    romb    retina    opening    tissue   

Project "ROMB" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙497˙175 €
 EC max contribution 1˙497˙175 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2025-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 1˙497˙175.00

Map

 Project objective

The retina carries signatures of neuronal diseases which have been linked to mechanical abnormalities, including Glaucoma and Alzheimer’s disease. Yet no biophysical retina model exists due to a cross-disciplinary challenge: While stem cell derived organoids mimic the retina in vitro, organoid research has been limited by large variations in cell and tissue organization. Mechanobiology, in turn, has revealed mechanical signals as essential players in regulating cellular behavior to guide organogenesis. Accordingly, the ball is in the court of physicists and bioengineers to quantify those mechanical signals and shape tissue growth by tailoring the physical interactions of cells with their environment. Finally, the functionality of the retina has to be quantified via neuroscience techniques. This multifaceted challenge has prevented the establishment of the retina organoid as a biophysical model. ROMB introduces a biophysical model for the retina which I will use to model Alzheimer’s disease in vitro. It will be built on 4 cross-disciplinary posts: (i) retina organoids as a physiological in vitro model, (ii) tissue mechanics measurements, (iii) neuronal activity readout and (iv) disease modeling. First, I will reveal the mechanical building plan of retina organoids using ferrofluid droplets as mechanical actuators, hereby opening the field of organoid mechanobiology. In a second step, the organoid’s 3D neuronal function will be recorded using lightsheet microscopy. Mechanical, functional and genetic access will allow me in a final step to detect and manipulate Alzheimer’s disease: using mouse retina organoids with a mutation in the App gene, I will mechanically characterize the formation of those peptide aggregates which are the hallmark of disease onset. ROMB opens the door to engineering functional retinas in vitro. Moreover, it will be uniquely suited to tackle mechanically related neuronal diseases and promises a breakthrough for basic and applied research.

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The information about "ROMB" are provided by the European Opendata Portal: CORDIS opendata.

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