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ROMB SIGNED

Retina Organoid Mechanobiology

Total Cost €

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EC-Contrib. €

0

Partnership

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 ROMB project word cloud

Explore the words cloud of the ROMB project. It provides you a very rough idea of what is the project "ROMB" about.

aggregates    opening    behavior    detect    glaucoma    app    gene    organogenesis    manipulate    mimic    revealed    mechanobiology    disciplinary    interactions    diseases    mechanical    cross    physiological    tackle    retinas    court    mouse    accordingly    neuroscience    variations    3d    door    organization    onset    cell    basic    regulating    engineering    modeling    posts    reveal    quantified    lightsheet    neuronal    guide    readout    first    abnormalities    genetic    retina    biophysical    organoids    mechanically    final    promises    multifaceted    players    limited    droplets    physicists    mutation    breakthrough    tailoring    cells    signatures    plan    shape    alzheimer    microscopy    peptide    introduces    bioengineers    hereby    quantify    functional    ball    opens    signals    disease    recorded    me    techniques    tissue    exists    building    turn    stem    actuators    ferrofluid    establishment    vitro    carries    physical    suited    uniquely    hallmark    environment    mechanics    romb    organoid    prevented    linked    cellular    function    model   

Project "ROMB" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙497˙175 €
 EC max contribution 1˙497˙175 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2025-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 1˙497˙175.00

Map

 Project objective

The retina carries signatures of neuronal diseases which have been linked to mechanical abnormalities, including Glaucoma and Alzheimer’s disease. Yet no biophysical retina model exists due to a cross-disciplinary challenge: While stem cell derived organoids mimic the retina in vitro, organoid research has been limited by large variations in cell and tissue organization. Mechanobiology, in turn, has revealed mechanical signals as essential players in regulating cellular behavior to guide organogenesis. Accordingly, the ball is in the court of physicists and bioengineers to quantify those mechanical signals and shape tissue growth by tailoring the physical interactions of cells with their environment. Finally, the functionality of the retina has to be quantified via neuroscience techniques. This multifaceted challenge has prevented the establishment of the retina organoid as a biophysical model. ROMB introduces a biophysical model for the retina which I will use to model Alzheimer’s disease in vitro. It will be built on 4 cross-disciplinary posts: (i) retina organoids as a physiological in vitro model, (ii) tissue mechanics measurements, (iii) neuronal activity readout and (iv) disease modeling. First, I will reveal the mechanical building plan of retina organoids using ferrofluid droplets as mechanical actuators, hereby opening the field of organoid mechanobiology. In a second step, the organoid’s 3D neuronal function will be recorded using lightsheet microscopy. Mechanical, functional and genetic access will allow me in a final step to detect and manipulate Alzheimer’s disease: using mouse retina organoids with a mutation in the App gene, I will mechanically characterize the formation of those peptide aggregates which are the hallmark of disease onset. ROMB opens the door to engineering functional retinas in vitro. Moreover, it will be uniquely suited to tackle mechanically related neuronal diseases and promises a breakthrough for basic and applied research.

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The information about "ROMB" are provided by the European Opendata Portal: CORDIS opendata.

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