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ROMB SIGNED

Retina Organoid Mechanobiology

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ROMB project word cloud

Explore the words cloud of the ROMB project. It provides you a very rough idea of what is the project "ROMB" about.

manipulate    environment    lightsheet    function    modeling    app    abnormalities    behavior    readout    neuronal    court    building    physicists    techniques    cell    neuroscience    revealed    quantify    mechanobiology    physiological    mouse    final    ball    basic    signals    3d    mechanics    biophysical    tissue    establishment    carries    organoid    bioengineers    quantified    mechanical    mimic    exists    vitro    signatures    regulating    linked    glaucoma    alzheimer    opening    tailoring    organogenesis    model    hereby    stem    detect    introduces    guide    cross    retina    me    cellular    physical    breakthrough    peptide    actuators    cells    recorded    door    multifaceted    genetic    uniquely    functional    opens    romb    suited    microscopy    diseases    disease    posts    accordingly    tackle    organoids    hallmark    engineering    ferrofluid    turn    promises    interactions    gene    variations    plan    limited    mutation    retinas    disciplinary    droplets    reveal    shape    players    onset    first    mechanically    organization    prevented    aggregates   

Project "ROMB" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙497˙175 €
 EC max contribution 1˙497˙175 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2025-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 1˙497˙175.00

Map

 Project objective

The retina carries signatures of neuronal diseases which have been linked to mechanical abnormalities, including Glaucoma and Alzheimer’s disease. Yet no biophysical retina model exists due to a cross-disciplinary challenge: While stem cell derived organoids mimic the retina in vitro, organoid research has been limited by large variations in cell and tissue organization. Mechanobiology, in turn, has revealed mechanical signals as essential players in regulating cellular behavior to guide organogenesis. Accordingly, the ball is in the court of physicists and bioengineers to quantify those mechanical signals and shape tissue growth by tailoring the physical interactions of cells with their environment. Finally, the functionality of the retina has to be quantified via neuroscience techniques. This multifaceted challenge has prevented the establishment of the retina organoid as a biophysical model. ROMB introduces a biophysical model for the retina which I will use to model Alzheimer’s disease in vitro. It will be built on 4 cross-disciplinary posts: (i) retina organoids as a physiological in vitro model, (ii) tissue mechanics measurements, (iii) neuronal activity readout and (iv) disease modeling. First, I will reveal the mechanical building plan of retina organoids using ferrofluid droplets as mechanical actuators, hereby opening the field of organoid mechanobiology. In a second step, the organoid’s 3D neuronal function will be recorded using lightsheet microscopy. Mechanical, functional and genetic access will allow me in a final step to detect and manipulate Alzheimer’s disease: using mouse retina organoids with a mutation in the App gene, I will mechanically characterize the formation of those peptide aggregates which are the hallmark of disease onset. ROMB opens the door to engineering functional retinas in vitro. Moreover, it will be uniquely suited to tackle mechanically related neuronal diseases and promises a breakthrough for basic and applied research.

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The information about "ROMB" are provided by the European Opendata Portal: CORDIS opendata.

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