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ARREST BLINDNESS SIGNED

Advanced Regenerative and REStorative Therapies to combat corneal BLINDNESS

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ARREST BLINDNESS" data sheet

The following table provides information about the project.

Coordinator
LINKOPINGS UNIVERSITET 

Organization address
address: CAMPUS VALLA
city: Linköping
postcode: 581 83
website: www.liu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 6˙030˙052 €
 EC max contribution 5˙993˙177 € (99%)
 Programme 1. H2020-EU.3.1. (SOCIETAL CHALLENGES - Health, demographic change and well-being)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme /RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LINKOPINGS UNIVERSITET SE (Linköping) coordinator 1˙623˙175.00
2    KLINIKUM DER UNIVERSITAET ZU KOELN DE (KOELN) participant 1˙122˙407.00
3    UNIVERSITAIR ZIEKENHUIS ANTWERPEN BE (EDEGEM) participant 738˙065.00
4    NETHERLANDS INSTITUTE FOR INNOVATIVE OCULAR SURGERY NL (ROTTERDAM) participant 622˙582.00
5    UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE ES (ELCHE) participant 397˙656.00
6    LINKOCARE LIFE SCIENCES AB SE (LINKOPING) participant 321˙278.00
7    OPTOMEDICAL TECHNOLOGIES GMBH DE (LUBECK) participant 281˙222.00
8    AEON ASTRON EUROPE B.V. NL (LEIDEN) participant 277˙075.00
9    AARHUS UNIVERSITET DK (AARHUS C) participant 237˙165.00
10    NOVALIQ GMBH DE (HEIDELBERG) participant 149˙250.00
11    LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG AT (WIEN) participant 142˙800.00
12    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 80˙500.00
13    GENE SIGNAL INTERNATIONAL SA CH (LAUSANNE) participant 0.00

Mappa

 Project objective

Over 30 million Europeans are blind or visually impaired, leading to reduced quality of life and a tremendous loss of productivity in society. Corneal blindness is the second largest cause of blindness globally and while treatable, millions remain unnecessarily blind due to issues of access to transplantable tissue, lack of standardized treatments, and the lag in translating new regenerative medicine therapies to the clinic. The objective of ARREST BLINDNESS is therefore to develop and validate new regenerative-based therapies addressing a spectrum of blinding disorders of the cornea. These conditions either have no effective current treatments, depend on a scarce supply of donor tissue, or non-standardized methods are hindering validation of promising regenerative treatments. To achieve our objective, we will implant GMP-fabricated collagen-based bioengineered scaffolds to replace or regenerate the corneal stroma in cases of stromal thinning, scarring, dystrophy or trauma; deliver therapeutic epithelial stem and endothelial cells to the cornea to restore its transparency; deliver regenerative factors to promote neural growth and function; and actively maintain corneal immune privilege in high-risk situations by targeted therapeutic approaches to regress blood and lymphatic vessels. We will additionally develop advanced methods to image and monitor therapy throughout the cycle from GMP-compliant cell and scaffold preparation through the pre- and intra-operative stages, to postoperative follow-up and evaluation. After proof-of-concept and preclinical validation of key enabling components, these technologies will be used by one or several partners in preclinical models and in phase I/II human clinical studies. ARREST BLINDNESS directly addresses the translation of regenerative medicine, bio-artificial organs, tissue engineered scaffolds, and advanced cell and gene therapies into clinical use and will help to alleviate the worldwide problem of corneal blindness.

 Work performed, outcomes and results:  advancements report(s) 

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The information about "ARREST BLINDNESS" are provided by the European Opendata Portal: CORDIS opendata.

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