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ARREST BLINDNESS SIGNED

Advanced Regenerative and REStorative Therapies to combat corneal BLINDNESS

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
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ARREST BLINDNESS project word cloud

Explore the words cloud of the ARREST BLINDNESS project. It provides you a very rough idea of what is the project "ARREST BLINDNESS" about.

regenerative therapeutic blindness scaffolds arrest cell therapies gmp standardized validation tissue blind corneal treatments clinical medicine cornea preclinical

Project "ARREST BLINDNESS" data sheet

The following table provides information about the project.

Coordinator	LINKOPINGS UNIVERSITET Organization address address: CAMPUS VALLA city: Linköping postcode: 581 83 website: www.liu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Total cost	6˙030˙052 €
EC max contribution	5˙993˙177 € (99%)
Programme	1. H2020-EU.3.1. (SOCIETAL CHALLENGES - Health, demographic change and well-being)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	/RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	LINKOPINGS UNIVERSITET LINKOPINGS UNIVERSITET Organization address address: CAMPUS VALLA city: Linköping postcode: 581 83 website: www.liu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (Linköping)	coordinator	1˙623˙175.00
2	KLINIKUM DER UNIVERSITAET ZU KOELN KLINIKUM DER UNIVERSITAET ZU KOELN Organization address address: Kerpener Strasse 62 city: KOELN postcode: 50937 website: www.uk-koeln.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KOELN)	participant	1˙122˙407.00
3	UNIVERSITAIR ZIEKENHUIS ANTWERPEN UNIVERSITAIR ZIEKENHUIS ANTWERPEN Organization address address: WILRIJKSTRAAT 10 city: EDEGEM postcode: 2650 website: www.uza.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (EDEGEM)	participant	738˙065.00
4	NETHERLANDS INSTITUTE FOR INNOVATIVE OCULAR SURGERY NETHERLANDS INSTITUTE FOR INNOVATIVE OCULAR SURGERY Organization address address: LAAN OP ZUID 88 city: ROTTERDAM postcode: 3071AA website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	622˙582.00
5	UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE Organization address address: AVENIDA DE LA UNIVERSIDAD S-N city: ELCHE postcode: 03202 website: www.umh.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (ELCHE)	participant	397˙656.00
6	LINKOCARE LIFE SCIENCES AB LINKOCARE LIFE SCIENCES AB Organization address address: MJARDEVI SCIENCE PARK, TEKNIKRINGEN 10, PLAN 3 city: LINKOPING postcode: 58330 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LINKOPING)	participant	321˙278.00
7	OPTOMEDICAL TECHNOLOGIES GMBH OPTOMEDICAL TECHNOLOGIES GMBH Organization address address: MARIA GOEPPERT STRASSE 9 city: LUBECK postcode: 23562 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LUBECK)	participant	281˙222.00
8	AEON ASTRON EUROPE B.V. AEON ASTRON EUROPE B.V. Organization address address: J.H. OORTWEG 19 city: LEIDEN postcode: 2333 CH website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	277˙075.00
9	AARHUS UNIVERSITET AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS C)	participant	237˙165.00
10	NOVALIQ GMBH NOVALIQ GMBH Organization address address: IM NEUENHEIMER FELD 515 city: HEIDELBERG postcode: 69120 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	149˙250.00
11	LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG Organization address address: NUSSDORFER STRASSE 64/6 city: WIEN postcode: 1090 website: http://www.lbitrauma.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	142˙800.00
12	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	80˙500.00
13	GENE SIGNAL INTERNATIONAL SA GENE SIGNAL INTERNATIONAL SA Organization address address: PARC SCIENTIFIQUE EPFL - PSE A city: LAUSANNE postcode: 1015 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	0.00

Mappa

Project objective

Over 30 million Europeans are blind or visually impaired, leading to reduced quality of life and a tremendous loss of productivity in society. Corneal blindness is the second largest cause of blindness globally and while treatable, millions remain unnecessarily blind due to issues of access to transplantable tissue, lack of standardized treatments, and the lag in translating new regenerative medicine therapies to the clinic. The objective of ARREST BLINDNESS is therefore to develop and validate new regenerative-based therapies addressing a spectrum of blinding disorders of the cornea. These conditions either have no effective current treatments, depend on a scarce supply of donor tissue, or non-standardized methods are hindering validation of promising regenerative treatments. To achieve our objective, we will implant GMP-fabricated collagen-based bioengineered scaffolds to replace or regenerate the corneal stroma in cases of stromal thinning, scarring, dystrophy or trauma; deliver therapeutic epithelial stem and endothelial cells to the cornea to restore its transparency; deliver regenerative factors to promote neural growth and function; and actively maintain corneal immune privilege in high-risk situations by targeted therapeutic approaches to regress blood and lymphatic vessels. We will additionally develop advanced methods to image and monitor therapy throughout the cycle from GMP-compliant cell and scaffold preparation through the pre- and intra-operative stages, to postoperative follow-up and evaluation. After proof-of-concept and preclinical validation of key enabling components, these technologies will be used by one or several partners in preclinical models and in phase I/II human clinical studies. ARREST BLINDNESS directly addresses the translation of regenerative medicine, bio-artificial organs, tissue engineered scaffolds, and advanced cell and gene therapies into clinical use and will help to alleviate the worldwide problem of corneal blindness.

Work performed, outcomes and results: advancements report(s)

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The information about "ARREST BLINDNESS" are provided by the European Opendata Portal: CORDIS opendata.