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ICARO SIGNED

Colloidal Inorganic Nanostructures for Radiotherapy and Chemotherapy

Total Cost €

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EC-Contrib. €

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Partnership

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 ICARO project word cloud

Explore the words cloud of the ICARO project. It provides you a very rough idea of what is the project "ICARO" about.

combine    magnetic    recognition    synthesis    soluble    aqueous    heterostructures    gt    local    cells    preparation    superparamagnetic    cation    least    replace    dose    severe    minimize    deg    triggered    hyperthermia    trials    situ    merge    preclinical    medical    surface    tested    prefunctionalized    cell    platform    bulk    protocols    semiconductor    operator    entity    combining    time    magnetically    effect    healthy    therapeutic    int    sp    crystal    clinical    introduce    specificity    radiolabelled    radio    last    exchange    portion    respect    first    heat    radionuclides    reactions    ncs    radiolabelling    entrapped    intercalation    cancer    types    nc    icaro    cations    exposure    simulates    46    exploits    lower    material    translated    matrix    perform    lack    pursued    post    made    explore    release    nanocrystal    ce    located    molecules    media    drug    tumor    easily    combination    radiotherapy    single    mass    treatments    lattice    possibly    water    intercalate    chemotherapy   

Project "ICARO" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙160˙000 €
 EC max contribution 1˙160˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 1˙160˙000.00

Map

 Project objective

Radio and chemotherapy are the major clinical treatments for cancer. However these treatments lack cell specificity and can have severe side effects against healthy cells, especially when used in combination. My goal is to develop a nanocrystal (NC) platform to merge radio and chemotherapy into a single entity that is more specific towards tumor cells. To achieve ICARO’s goal, three main objectives will be pursued. The first objective is to introduce post-synthesis reactions, namely cation exchange (CE) and intercalation (INT) reactions, as new protocols to replace or intercalate cations that are useful as radionuclides within the crystal lattice of water-soluble NCs. Our goal is to establish protocols for the preparation of radiolabelled-NCs that will be easily translated to the medical practice for radiotherapy. This requires CE/INT reactions that occur in aqueous media, possibly with NCs prefunctionalized with specific recognition molecules to achieve targeted radiotherapy. To minimize the radio exposure of the operator, CE/INT protocols will be carried out as the last step of NC preparation. The second objective of ICARO will be to explore in situ CE/INT reactions with NCs entrapped in a matrix that simulates the tumor mass. By first located NCs at the tumor and then let the CE/INT to occur, enhance therapeutic effect is expected. The third objective of ICARO will be to develop heterostructures to combine radio and chemotherapy. They will include at least one semiconductor NC on which to perform radiolabelling protocols and one portion made of a superparamagnetic (SP) NC for magnetically triggered drug release. With respect to magnetic hyperthermia, which exploits SP-NCs to produce bulk heat (>46°C) at the tumor, the local heat effect generated at the surface of SP-NCs will enable drug release using a lower dose of magnetic material. Finally, new types of heterostructures combining radio and chemotherapy will be tested, for the first time, in preclinical trials.

 Publications

year authors and title journal last update
List of publications.
2016 Aidin Lak, Dina Niculaes, George C. Anyfantis, Giovanni Bertoni, Markus J. Barthel, Sergio Marras, Marco Cassani, Simone Nitti, Athanassia Athanassiou, Cinzia Giannini, Teresa Pellegrino
Facile transformation of FeO/Fe3O4 core-shell nanocubes to Fe3O4 via magnetic stimulation
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep33295
Scientific Reports 6/1 2019-07-22
2017 Maria Elena Materia, Manuel Pernia Leal, Marco Scotto, Preethi Bala Balakrishnan, Sahitya Avugadda Kumar, María Luisa García-Martín, Bruce E Cohen, Emory M. Chan, Teresa Pellegrino
Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools
published pages: , ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.7b00432
Bioconjugate Chemistry 2019-07-22
2017 Alessandra Quarta, Marina Rodio, Marco Cassani, Giuseppe Gigli, Teresa Pellegrino, Loretta L. del Mercato
Multilayered Magnetic Nanobeads for the Delivery of Peptides Molecules Triggered by Intracellular Proteases
published pages: 35095-35104, ISSN: 1944-8244, DOI: 10.1021/acsami.7b05709
ACS Applied Materials & Interfaces 9/40 2019-07-22
2018 Preethi Bala Balakrishnan, Lorenza Gardella, Mahdi Forouharshad, Teresa Pellegrino, Orietta Monticelli
Star poly(ε-caprolactone)-based electrospun fibers as biocompatible scaffold for doxorubicin with prolonged drug release activity
published pages: 488-496, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2017.11.014
Colloids and Surfaces B: Biointerfaces 161 2019-07-22
2017 Silvia Dante, Alessia Petrelli, Enrica Maria Petrini, Roberto Marotta, Alessandro Maccione, Alessandro Alabastri, Alessandra Quarta, Francesco De Donato, Tiziana Ravasenga, Ayyappan Sathya, Roberto Cingolani, Remo Proietti Zaccaria, Luca Berdondini, Andrea Barberis, Teresa Pellegrino
Selective Targeting of Neurons with Inorganic Nanoparticles: Revealing the Crucial Role of Nanoparticle Surface Charge
published pages: 6630-6640, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b00397
ACS Nano 11/7 2019-07-22
2017 P. Guardia, S. Nitti, M. E. Materia, G. Pugliese, N. Yaacoub, J.-M. Greneche, C. Lefevre, L. Manna, T. Pellegrino
Gold–iron oxide dimers for magnetic hyperthermia: the key role of chloride ions in the synthesis to boost the heating efficiency
published pages: 4587-4594, ISSN: 2050-7518, DOI: 10.1039/c7tb00968b
J. Mater. Chem. B 5/24 2019-07-22
2016 Sandeep Ghosh, Tommaso Avellini, Alessia Petrelli, Ilka Kriegel, Roberto Gaspari, Guilherme Almeida, Giovanni Bertoni, Andrea Cavalli, Francesco Scotognella, Teresa Pellegrino, Liberato Manna
Colloidal CuFeS 2 Nanocrystals: Intermediate Fe d-Band Leads to High Photothermal Conversion Efficiency
published pages: 4848-4858, ISSN: 0897-4756, DOI: 10.1021/acs.chemmater.6b02192
Chemistry of Materials 28/13 2019-07-22
2016 Dina Niculaes, Aidin Lak, George C. Anyfantis, Sergio Marras, Oliver Laslett, Sahitya K. Avugadda, Marco Cassani, David Serantes, Ondrej Hovorka, Roy Chantrell, Teresa Pellegrino
Asymmetric Assembling of Iron Oxide Nanocubes for Improving Magnetic Hyperthermia Performance
published pages: 12121-12133, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b05182
ACS Nano 11/12 2019-07-22
2018 Hamilton Kakwere, Maria Elena Materia, Alberto Curcio, Mirko Prato, Ayyappan Sathya, Simone Nitti, Teresa Pellegrino
Dually responsive gold–iron oxide heterodimers: merging stimuli-responsive surface properties with intrinsic inorganic material features
published pages: 3930-3944, ISSN: 2040-3364, DOI: 10.1039/C7NR06726G
Nanoscale 10/8 2019-07-22
2017 D. Cabrera, A. Lak, T. Yoshida, M. E. Materia, D. Ortega, F. Ludwig, P. Guardia, A. Sathya, T. Pellegrino, F. J. Teran
Unraveling viscosity effects on the hysteresis losses of magnetic nanocubes
published pages: 5094-5101, ISSN: 2040-3364, DOI: 10.1039/C7NR00810D
Nanoscale 9/16 2019-07-22
2018 Binh T. Mai, Soraia Fernandes, Preethi B. Balakrishnan, Teresa Pellegrino
Nanosystems Based on Magnetic Nanoparticles and Thermo- or pH-Responsive Polymers: An Update and Future Perspectives
published pages: 999-1013, ISSN: 0001-4842, DOI: 10.1021/acs.accounts.7b00549
Accounts of Chemical Research 51/5 2019-07-22

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