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DISSection SIGNED

Doctoral Industrial School on Human Skin models for Staphylococcal infections

Total Cost €

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EC-Contrib. €

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Partnership

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Project "DISSection" data sheet

The following table provides information about the project.

Coordinator
GLAXOSMITHKLINE VACCINES SRL 

Organization address
address: VIA FIORENTINA 1
city: SIENA
postcode: 53100
website: www.novartis.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.dissection.eu
 Total cost 1˙026˙871 €
 EC max contribution 1˙026˙871 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-EID
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GLAXOSMITHKLINE VACCINES SRL IT (SIENA) coordinator 516˙122.00
2    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 510˙748.00

Map

 Project objective

Staphylococcus aureus (S. aureus) is a major human pathogen and cutaneous infections are among the leading cause of emergency department visits. Unfortunately, S. aureus vaccine development is hindered by the lack of known correlates of protection. Three dimensional organotypic human skin models may represent a valid alternative to animal infection model. Indeed, S. aureus expresses several human-specific virulence factors. However, at the present such models have been rarely used in the S. aureus research field and, to our knowledge, never with immune-competent models. Therefore, a major aim of this proposal is to develop a human skin equivalent and integrate key immune components in the epithelial matrix. To accomplish this goal we will take advantage of cutting-edge technologies, such as induced pluripotent stem cells to generate macrophages and neutrophils. The model will be used and optimized to the following main objectives: better understanding of human-specific pathogenesis of S. aureus as well as protective mechanisms against the pathogen; development of the first immune-competent human skin models for vaccine research; determine the role of bacterial communities on skin infections; provide alternative methods to animal models. The proposed scientific program will be complemented with a number of training courses based on specific skills for which both the University of Utrecht and Novartis Vaccines are renowned. Complementary courses on dermatology, human skin infections, hydrogel scaffolds, mass spectrometry, and induced pluripotent stem technology, will be held by associate partners. At the end of the project the students will receive a PhD degree in the area of Infection and Immunity. We believe that this project is at the leading edge of science and technology and represents a good opportunity for students that are willing to grow both in basic science as well as innovative and applicative research.

 Deliverables

List of deliverables.
“Skin model & Vaccinology” workshops Documents, reports 2019-05-09 11:48:55
Website Websites, patent fillings, videos etc. 2019-05-09 11:48:56
Local Training reports Documents, reports 2019-05-09 11:48:56
Annual DISSection meetings Documents, reports 2019-05-09 11:48:56
Dissemination reports Websites, patent fillings, videos etc. 2019-05-09 11:48:55
Meetings proceedings Websites, patent fillings, videos etc. 2019-05-09 11:48:56
Transferable Skills Courses Documents, reports 2019-05-09 11:48:55
Outreach reports Documents, reports 2019-05-09 11:48:55
Recruitment Other 2019-05-09 11:48:55
Supervisory Board Other 2019-05-09 11:48:55

Take a look to the deliverables list in detail:  detailed list of DISSection deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Astrid Hendriks, Ana Rita Cruz, Elisabetta Soldaini, Andrea Guido Oreste Manetti, Fabio Bagnoli
Human Organotypic Models for Anti-infective Research
published pages: , ISSN: , DOI: 10.1007/82_2018_130
Current Topics in Microbiology and Immunology 2019-05-09

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The information about "DISSECTION" are provided by the European Opendata Portal: CORDIS opendata.

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