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JOLI SIGNED

Using the jellyfish Clytia hemisphaerica to explore the first steps of meiosis by live-imaging.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 JOLI project word cloud

Explore the words cloud of the JOLI project. It provides you a very rough idea of what is the project "JOLI" about.

morphology    comprising    strand    introducing    break    meiosis    solid    crispr    days    chromosomes    isolated    multifaceted    experimental    transgenics    fluorescent    hydrozoan    cellular    expert    stem    regulated    female    oogenesis    expertise    spo11    combining    shift    enzyme    ex    proliferation    clear    meiotic    hemisphaerica    entire    cartography    precursors    model    gene    microscopy    biology    markers    events    labs    homologous    live    movements    progression    cnidarian    developmental    chromosome    transfer    precursor    time    pairing    skills    whilst    synaptonemal    candidate    molecular    complementary    imaging    mediated    inaccessible    transition    animal    cell    function    vivo    simply    first    series    clytia    mitotic    dynamics    monitoring    spatiotemporal    germ    characterisation    gonads    largely    optically    fulfill    foundation    host    sites    pools    double    entry    oocyte    career    polymerisation    carefully    knockout    models    strengths    bioinformatics   

Project "JOLI" data sheet

The following table provides information about the project.

Coordinator
COLLEGE DE FRANCE 

Organization address
address: PLACE MARCELIN BERTHELOT 11
city: PARIS
postcode: 75005
website: www.college-de-france.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    COLLEGE DE FRANCE FR (PARIS) coordinator 196˙707.00

Map

 Project objective

Oocyte production is a key feature of animal development, comprising a series of carefully regulated events. This project will exploit a new experimental model, the hydrozoan Clytia hemisphaerica, to analyse by live imaging approaches the entire process of oogenesis in isolated female gonads from stem cell to oocyte for the first time. Analyses will focus on early events largely inaccessible in existing animal models, covering the transition from mitotic proliferation of germ cell precursors to meiotic entry. Key events include homologous chromosome pairing, synaptonemal complex formation, and meiotic double strand break formation. Clytia gonads are optically clear, simply organised and maintain oocyte production for several days ex-vivo. The three specific project objectives are 1) to define the spatiotemporal progression of early oogenesis through molecular cartography of the different precursor pools and cell morphology characterisation; 2) to establish conditions for long term imaging, including development of fluorescent markers; 3) to address the function of the key enzyme Spo11 by combining live imaging with CRISPR-mediated gene knockout, monitoring the movements of homologous chromosomes during pairing and identifying the sites of synaptonemal complex polymerisation. This multifaceted project represents a thematic shift for the applicant and involves a new collaboration between expert labs with complementary strengths in developmental, molecular, and cellular biology. Two-way transfer of knowledge will enable the candidate to develop new skills (microscopy, live imaging, transgenics) whilst introducing her existing expertise with cnidarian biology and bioinformatics to the host labs. The project will improve understanding of the cellular and molecular dynamics of meiosis, establish a new experimental model for oogenesis studies, and provide the candidate with a solid foundation of complementary experience to fulfill her long term career objectives.

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The information about "JOLI" are provided by the European Opendata Portal: CORDIS opendata.

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