Explore the words cloud of the AXIAL.EC project. It provides you a very rough idea of what is the project "AXIAL.EC" about.
The following table provides information about the project.
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
|Coordinator Country||Portugal [PT]|
|Total cost||1˙618˙750 €|
|EC max contribution||1˙618˙750 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-09-01 to 2021-08-31|
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|1||INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES||PT (LISBOA)||coordinator||1˙618˙750.00|
The formation of a functional patterned vascular network is essential for development, tissue growth and organ physiology. Several human vascular disorders arise from the mis-patterning of blood vessels, such as arteriovenous malformations, aneurysms and diabetic retinopathy. Although blood flow is recognised as a stimulus for vascular patterning, very little is known about the molecular mechanisms that regulate endothelial cell behaviour in response to flow and promote vascular patterning. Recently, we uncovered that endothelial cells migrate extensively in the immature vascular network, and that endothelial cells polarise against the blood flow direction. Here, we put forward the hypothesis that vascular patterning is dependent on the polarisation and migration of endothelial cells against the flow direction, in a continuous flux of cells going from low-shear stress to high-shear stress regions. We will establish new reporter mouse lines to observe and manipulate endothelial polarity in vivo in order to investigate how polarisation and coordination of endothelial cells movements are orchestrated to generate vascular patterning. We will manipulate cell polarity using mouse models to understand the importance of cell polarisation in vascular patterning. Also, using a unique zebrafish line allowing analysis of endothelial cell polarity, we will perform a screen to identify novel regulators of vascular patterning. Finally, we will explore the hypothesis that defective flow-dependent endothelial polarisation underlies arteriovenous malformations using two genetic models. This integrative approach, based on high-resolution imaging and unique experimental models, will provide a unifying model defining the cellular and molecular principles involved in vascular patterning. Given the physiological relevance of vascular patterning in health and disease, this research plan will set the basis for the development of novel clinical therapies targeting vascular disorders.
|year||authors and title||journal||last update|
Filipa Neto, Alexandra Klaus-Bergmann, Yu Ting Ong, Silvanus Alt, Anne-ClÃ©mence Vion, Anna Szymborska, Joana R Carvalho, Irene Hollfinger, Eireen Bartels-Klein, Claudio A Franco, Michael Potente, Holger Gerhardt
YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.31037
Takao Hikita, Fatemeh Mirzapourshafiyi, Pedro Barbacena, Meghan Riddell, Ayesha Pasha, Mengnan Li, Takuji Kawamura, Ralf P Brandes, Tomonori Hirose, Shigeo Ohno, Holger Gerhardt, Michiyuki Matsuda, Claudio A Franco, Masanori Nakayama
PARâ€3 controls endothelial planar polarity and vascular inflammation under laminar flow
published pages: e45253, ISSN: 1469-221X, DOI: 10.15252/embr.201745253
Stefanie Hendrikx, Sanja Coso, Borja Prat-Luri, Laureline Wetterwald, AmÃ©lie Sabine, Claudio A. Franco, Sina Nassiri, Nadine Zangger, Holger Gerhardt, Mauro Delorenzi, Tatiana V. Petrova
Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2
published pages: 1227-1241.e6, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.01.016
|Cell Reports 26/5||2019-05-27|
Joana R Carvalho, Isabela C Fortunato, Catarina G Fonseca, Anna Pezzarossa, Pedro Barbacena, Maria A Dominguez-Cejudo, Francisca F Vasconcelos, Nuno C Santos, Filomena A Carvalho, Claudio A Franco
Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.45853
Yang Lu, Miguel O. Bernabeu, Jan Lammer, Charles C. Cai, Martin L. Jones, Claudio A. Franco, Lloyd Paul Aiello, Jennifer K. Sun
Computational fluid dynamics assisted characterization of parafoveal hemodynamics in normal and diabetic eyes using adaptive optics scanning laser ophthalmoscopy
published pages: 4958, ISSN: 2156-7085, DOI: 10.1364/BOE.7.004958
|Biomedical Optics Express 7/12||2019-05-14|
Claudio A. Franco, Holger Gerhardt
Morph or Move? How Distinct Endothelial Cell Responses to Blood Flow Shape Vascular Networks
published pages: 574-576, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2017.06.008
|Developmental Cell 41/6||2019-05-14|
Claudio A. Franco, Holger Gerhardt
Blood flow boosts BMP signaling to keep vessels in shape
published pages: 793-795, ISSN: 0021-9525, DOI: 10.1083/jcb.201609038
|The Journal of Cell Biology 214/7||2019-06-19|
Miguel O. Bernabeu, Martin L. Jones, Rupert W. Nash, Anna Pezzarossa, Peter V. Coveney, Holger Gerhardt, Claudio A. Franco
PolNet: A Tool to Quantify Network-Level Cell Polarity and Blood Flow in Vascular Remodeling
published pages: 2052-2058, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2018.03.032
|Biophysical Journal 114/9||2019-05-27|
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