Opendata, web and dolomites

PolyDomFormFuncReg SIGNED

Discovering how polycomb domains form and function in gene regulation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "PolyDomFormFuncReg" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙999˙416 €
 EC max contribution 1˙999˙416 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 1˙999˙416.00

Map

 Project objective

Polycomb group chromatin modifying systems are essential for normal gene regulation and development, and alterations in their activity are a hallmark of a broad range of cancers. Although the chromatin modifications placed by the two central polycomb protein complexes (PRC1 and PRC2) are well-characterized, how this fascinating system selects its target sites in vivo, and then forms polycomb chromatin domains that are repressive to transcription remains enigmatic. This constitutes the major conceptual gap in our understanding of this essential gene regulatory system. We recently discovered a new pathway that is sufficient in model systems to initiate polycomb chromatin domain formation. Building on this discovery, an ambitious high-risk/high-reward yet hypothesis-driven multidisciplinary approach integrating biochemical, molecular, genomic, and single-cell analyses will be exploited to discover the fundamental principles that underpin polycomb domain formation and subsequently transcriptional repression. Specifically, the three aims of the research programme are to: (i) Discover how the KDM2B/PRC1 complex initiates polycomb domain formation, (ii) Discover how polycomb target sites are selected and polycomb domains formed during normal cell lineage commitment, and (iii) Discover how polycomb domains regulate gene expression. Going well beyond the state-of-the-art, our innovative approaches will lead to major new breakthroughs closing the conceptual gap that currently limits our understanding of how polycomb complexes regulate gene expression, an essential first step towards the possibility of devising strategies for therapeutic intervention in human cancers and other diseases where these systems are perturbed. Furthermore, support from the ERC in tackling these important problems will allow me to recruit the talented individuals necessary to achieve our objectives and consolidate my position as an emerging leader in the field.

 Publications

year authors and title journal last update
List of publications.
2019 Nadezda A. Fursova, Neil P. Blackledge, Manabu Nakayama, Shinsuke Ito, Yoko Koseki, Anca M. Farcas, Hamish W. King, Haruhiko Koseki, Robert J. Klose
Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression
published pages: 1020-1036.e8, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.03.024
Molecular Cell 74/5 2019-08-05
2019 JDP Rhodes, A Feldmann, B Hernández-Rodríguez, N Díaz, JM Brown, NA Fursova, NP Blackledge, P Prathapan, P Dobrinic, M Huseyin, A Szczurek, K Kruse, KA Nasmyth, VJ Buckle, JM Vaquerizas, RJ Klose
Cohesin disrupts polycomb-dependent chromosome interactions
published pages: , ISSN: , DOI: 10.1101/593970
BioRxiv 2019-08-05
2019 Neil P. Blackledge, Nadezda A. Fursova, Jessica R. Kelley, Miles K. Huseyin, Angelika Feldmann, Robert J. Klose
PRC1 catalytic activity is central to Polycomb system function
published pages: , ISSN: , DOI: 10.1101/667667
BioRxiv 2019-08-05
2016 Nathan R Rose, Hamish W King, Neil P Blackledge, Nadezda A Fursova, Katherine JI Ember, Roman Fischer, Benedikt M Kessler, Robert J Klose
RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.18591
eLife 5 2019-06-18
2018 Hamish W. King, Nadezda A. Fursova, Neil P. Blackledge, Robert J. Klose
Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes
published pages: 1494-1507, ISSN: 1088-9051, DOI: 10.1101/gr.237180.118
Genome Research 28/10 2019-02-25

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "POLYDOMFORMFUNCREG" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "POLYDOMFORMFUNCREG" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

SUExp (2018)

Strategic Uncertainty: An Experimental Investigation

Read More  

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

MitoGuide (2019)

Integration and adaptation of impaired mitochondrial fitness in orchestrating T cell dysfunction in the tumor microenvironment

Read More