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APPELS SIGNED

A Probe of the Periodic Elements for Life in the Sea

Total Cost €

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EC-Contrib. €

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Partnership

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 APPELS project word cloud

Explore the words cloud of the APPELS project. It provides you a very rough idea of what is the project "APPELS" about.

microscopic    centres    world    geochemical    elemental    life    easily    broadest    pronged    constrained    prong    exert    expanse    pumping    proteins    genomes    earth    comprehensively    metals    bioinorganic    spectrometry    techniques    proteomics    critical    function    chemical    mass    cellular    lowered    decoding    quotas    relies    building    influence    pump    limitation    biological    distributions    ambiguity    representative    blocks    opaque    nutrients    explore    geared    concentrations    climate    photosynthesising    gigantic    examined    rate    cutting    inferred    chemistry    edge    metal    metalloproteome    carbon    nutrition    atmosphere    appels    nutrient    fundamental    chemotypes    transform    biochemical    unite    media    identity    protein    manipulated    modern    ocean    marine    phytoplankton    stature    delineate    trace    implications    periodic    discovery    table    metalloproteins    recognised    palette    maximum    implies    whereby    documented    remarkably    uses    broadly    susceptible    binding    dimension    deep    poorly    mistaken    physiological    optimal    metallome   

Project "APPELS" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.earth.ox.ac.uk/research-groups/ocean-biogeochemistry/research-projects/
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙000˙000.00

Map

 Project objective

'Chemical elements are the building blocks of life. The major elements, C, H. O, N, P, S are easily recognised as essential nutrients, but their use by life relies on metalloproteins. The identity of the metal centres of these metalloproteins and even the broader palette of trace elements fundamental to life are remarkably poorly known. Whole genomes remain opaque to decoding of this bioinorganic dimension, and optimal trace element concentrations for physiological function. Defining the elemental requirements for maximum growth rate of photosynthesising phytoplankton in the ocean, is critical to understanding Earth's climate. Although microscopic in stature, phytoplankton exert a gigantic influence on the biological pumping of carbon from the atmosphere to the deep ocean. Yet their metal requirements are poorly constrained, being inferred from cellular quotas and 'nutrient-like' ocean metal distributions, susceptible to ambiguity between mistaken cellular uptake and use. APPELS will undertake a two-pronged approach to define the modern marine metallome/metalloproteome. I will explore the expanse of the periodic table for novel required elements by growing phytoplankton, representative of the broadest chemotypes, in manipulated media, to delineate optimal conditions for growth whereby any limitation at lowered concentrations implies use. The second prong uses cutting-edge techniques that unite methods from proteomics with geochemical mass-spectrometry to allow both metals and their associated proteins to be examined comprehensively. APPELS will transform our understanding of the essential elements in the ocean and how the biological pump of carbon is geared to ocean chemistry in an evolving world. More broadly, APPELS will provide a step change in documented protein-metal binding centres, with implications for discovery of novel biochemical pathways, and optimal nutrition.'

 Publications

year authors and title journal last update
List of publications.
2018 Qiong Zhang, Joseph T. Snow, Phil Holdship, David Price, Paul Watson, Rosalind E. M. Rickaby
Direct measurement of multi-elements in high matrix samples with a flow injection ICP-MS: application to the extended Emiliania huxleyi Redfield ratio
published pages: 1196-1208, ISSN: 0267-9477, DOI: 10.1039/c8ja00031j
Journal of Analytical Atomic Spectrometry 33/7 2019-02-26

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