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APPELS SIGNED

A Probe of the Periodic Elements for Life in the Sea

Total Cost €

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EC-Contrib. €

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Partnership

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 APPELS project word cloud

Explore the words cloud of the APPELS project. It provides you a very rough idea of what is the project "APPELS" about.

remarkably    nutrients    metalloproteome    microscopic    biochemical    earth    fundamental    deep    quotas    proteins    recognised    protein    geared    exert    nutrition    easily    photosynthesising    climate    inferred    maximum    chemical    manipulated    trace    biological    blocks    broadest    comprehensively    ambiguity    life    mass    centres    expanse    cutting    implies    phytoplankton    relies    palette    chemotypes    decoding    binding    delineate    discovery    influence    appels    atmosphere    documented    marine    representative    bioinorganic    function    explore    cellular    nutrient    whereby    building    geochemical    distributions    elemental    proteomics    mistaken    rate    world    prong    uses    susceptible    pronged    opaque    modern    physiological    pumping    poorly    constrained    critical    pump    media    dimension    concentrations    broadly    implications    table    techniques    metals    edge    spectrometry    examined    carbon    gigantic    limitation    stature    transform    lowered    optimal    identity    unite    chemistry    metallome    metal    periodic    genomes    metalloproteins    ocean   

Project "APPELS" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.earth.ox.ac.uk/research-groups/ocean-biogeochemistry/research-projects/
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙000˙000.00

Map

 Project objective

'Chemical elements are the building blocks of life. The major elements, C, H. O, N, P, S are easily recognised as essential nutrients, but their use by life relies on metalloproteins. The identity of the metal centres of these metalloproteins and even the broader palette of trace elements fundamental to life are remarkably poorly known. Whole genomes remain opaque to decoding of this bioinorganic dimension, and optimal trace element concentrations for physiological function. Defining the elemental requirements for maximum growth rate of photosynthesising phytoplankton in the ocean, is critical to understanding Earth's climate. Although microscopic in stature, phytoplankton exert a gigantic influence on the biological pumping of carbon from the atmosphere to the deep ocean. Yet their metal requirements are poorly constrained, being inferred from cellular quotas and 'nutrient-like' ocean metal distributions, susceptible to ambiguity between mistaken cellular uptake and use. APPELS will undertake a two-pronged approach to define the modern marine metallome/metalloproteome. I will explore the expanse of the periodic table for novel required elements by growing phytoplankton, representative of the broadest chemotypes, in manipulated media, to delineate optimal conditions for growth whereby any limitation at lowered concentrations implies use. The second prong uses cutting-edge techniques that unite methods from proteomics with geochemical mass-spectrometry to allow both metals and their associated proteins to be examined comprehensively. APPELS will transform our understanding of the essential elements in the ocean and how the biological pump of carbon is geared to ocean chemistry in an evolving world. More broadly, APPELS will provide a step change in documented protein-metal binding centres, with implications for discovery of novel biochemical pathways, and optimal nutrition.'

 Publications

year authors and title journal last update
List of publications.
2018 Qiong Zhang, Joseph T. Snow, Phil Holdship, David Price, Paul Watson, Rosalind E. M. Rickaby
Direct measurement of multi-elements in high matrix samples with a flow injection ICP-MS: application to the extended Emiliania huxleyi Redfield ratio
published pages: 1196-1208, ISSN: 0267-9477, DOI: 10.1039/c8ja00031j
Journal of Analytical Atomic Spectrometry 33/7 2019-02-26

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