Opendata, web and dolomites

hRBP-virion

Comprehensive identification of host factors involved in the early steps of HIV infection.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 hRBP-virion project word cloud

Explore the words cloud of the hRBP-virion project. It provides you a very rough idea of what is the project "hRBP-virion" about.

expertise    generation    disciplines    aids    basic    viruses    human    reported    atmosphere    hence    mix    exclusive    innovation    rate    broad    emerge    me    avenues    35    action    multidisciplinary    systematic    pooled    successful    significance    strategies    loading    incorporated    disciplinary    competences    refractory    infected    reduce    dependency    people    therapeutic    cross    virus    scope    proteomic    drug    mutation    hiv    shown    undetectable    hrbp    outcome    rna    cocktails    virology    pioneer    binding    unprecedented    complementary    anti    evolution    selectively    class    virion    intervention    viral    infection    health    virions    cure    data    proteins    therapies    strict    immunodeficiency    proteomics    levels    transfer    biology    million    appropriate    question    create    biological    prioritizes    resistance    causative    supervisor    excellent    world    downstream    retrovirals    packed    molecular    explore    train    combines    sporadic    cutting    host    agent    socioeconomic    global    facilities    rbps    edge   

Project "hRBP-virion" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://hrbpvirion.wordpress.com/
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-03   to  2019-05-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 195˙454.00

Map

 Project objective

35 million people are currently infected with Human immunodeficiency virus (HIV), causative agent of AIDS. While cocktails of anti-retrovirals can reduce viral loading to undetectable levels, drug resistance can emerge due to the high-mutation rate of the virus. Moreover, no cure is yet achieved. Therefore, it is crucial to explore complementary therapeutic strategies, a challenge that H2020 prioritizes in health. The strict dependency of HIV on host RNA-binding proteins (RBPs) represents a potential step for intervention through host-based therapies, which can be more refractory to the evolution of resistance. In some sporadic cases, host RBPs have been shown to be incorporated into virions and impact downstream early steps of infection. However, no global and systematic studies aimed to determine the scope and biological significance of host RBPs selectively packed with the HIV RNA within the virions have been reported so far. The main goal of this action, referred to as hRBP-virion, is to address this important biological question by developing an unprecedented multidisciplinary approach that combines molecular biology and virology methods with next generation proteomics and data analysis. Hence, this pioneer approach will open new avenues of research in the field of viruses that have major health and socioeconomic impact and will enhance world-class basic and applied European innovation. The hRBP-virion project requires an exclusive mix of competences. I will bring research experience in RNA and molecular virology. My supervisor will train me in cutting-edge, system-wide proteomic methods. The host institution will provide state-of-the-art facilities and pooled expertise in a broad range of disciplines. Together these will create an excellent and unique cross-disciplinary atmosphere that will ensure the successful outcome of hRBP-virion and the appropriate transfer of knowledge among the participants.

 Publications

year authors and title journal last update
List of publications.
2018 Manuel Garcia-Moreno, Aino I. Järvelin, Alfredo Castello
Unconventional RNA-binding proteins step into the virus-host battlefront
published pages: e1498, ISSN: 1757-7004, DOI: 10.1002/wrna.1498
Wiley Interdisciplinary Reviews: RNA 9/6 2019-09-25
2019 Manuel Garcia-Moreno, Marko Noerenberg, Shuai Ni, Aino I. Järvelin, Esther González-Almela, Caroline E. Lenz, Marcel Bach-Pages, Victoria Cox, Rosario Avolio, Thomas Davis, Svenja Hester, Thibault J.M. Sohier, Bingnan Li, Gregory Heikel, Gracjan Michlewski, Miguel A. Sanz, Luis Carrasco, Emiliano P. Ricci, Vicent Pelechano, Ilan Davis, Bernd Fischer, Shabaz Mohammed, Alfredo Castello
System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection
published pages: 196-211.e11, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.01.017
Molecular Cell 74/1 2019-09-25

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HRBP-VIRION" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HRBP-VIRION" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

PaSION (2018)

A longitudinal assessment of treatment experience, symptoms and potential associations with biomarkers in cancer patients undergoing immune checkpoint inhibitor therapy

Read More  

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More  

MegaBiCycle (2019)

The role of megafauna in biogeochemical cycles and greenhouse gas fluxes: implications for climate and ecosystems throughout history

Read More