Opendata, web and dolomites

Spotifly SIGNED

Genetic paths underlying the convergent evolution of pigmented spots on fly wings

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "Spotifly" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.evolutionary-ecology.bio.lmu.de/evolution_development/index.html
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 159˙460.00

Map

 Project objective

When a phenotype evolves twice in independent lineages, are the underlying molecular mechanisms similar? In the case of similar pigmentation patterns that have arisen independently in two fruit fly species, Drosophila tristis and Drosophila biarmipes, the question, becomes: is there a unique genetic path to gain a pigmentation spot on the wing? Each pigmentation pattern is prefigured by the developmental expression of yellow, a gene necessary for the production of black pigments. In each case, yellow expression results from a novel enhancer, both enhancers sharing no homology. To understand how these new regulatory activities have independently emerged, we will first perform an RNAi screen to identify transcription factors controlling each enhancer. We will then characterize the candidate transcription factors identified, assess their genetic sufficiency and the directness of the regulatory link. We will evaluate the degree of convergence in the control of the activity of the two enhancers by closely comparing the relationship between their structure and their function. We will compare sequences between species that carry the regulatory activity and species that do not. We will identify in which context binding sites that convey the activity evolved (position, spacing, orientation). Moreover, we will distinguish among sites contributing permissive or instructive (spatio-temporal) input. This project tackles the open question of how a new regulatory activity emerges. The contribution of each input is key element to enhancer activity, and is hardly understood in any system. The model we use may represent a rare case where the evolution of a regulatory activity can be deciphered functionally. Our work will also address the question of the repeated evolution of complex traits, often associated to regulatory changes. We will assess the level of functional constraint that may channel the emergence of the same regulatory activity to the same molecular mechanisms.

 Publications

year authors and title journal last update
List of publications.
2018 Hélène Hinaux, Katharina Bachem, Margherita Battistara, Matteo Rossi, Yaqun Xin, Rita Jaenichen, Yann Le Poul, Laurent Arnoult, Johanna M. Kobler, Ilona Grunwald Kadow, Lisa Rodermund, Benjamin Prud’homme, Nicolas Gompel
Revisiting the developmental and cellular role of the pigmentation gene yellow in Drosophila using a tagged allele
published pages: , ISSN: 0012-1606, DOI: 10.1016/j.ydbio.2018.04.003
Developmental Biology 2019-06-13

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SPOTIFLY" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SPOTIFLY" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ELOTEQ (2019)

Interfacing Levitated Optomechanics with Superconducting Qubits

Read More  

BiMetaCat (2019)

Two Are Better Than One: Bimetallic Catalysts for the Conversion of Lignin-Derived Aryl-Ethers

Read More  

Light UP (2020)

Visible Light Ultrafast Photodetector for Optical Wireless Communication Technology

Read More