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Cortical circuit assembly in the developing mouse neocortex

Total Cost €


EC-Contrib. €






Project "CorCir" data sheet

The following table provides information about the project.


Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-08-15   to  2019-08-14


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00


 Project objective

The developing neocortex consists of two major neuronal subtypes–pyramidal neurons and interneurons. These two subtypes come together in the cortical plate, forming cortical circuits that can integrate and respond to external and internal stimuli. Despite recent advancement in the research on cortical networks of the developing brain, the mechanism involved in cortical circuit assembly remains relatively unexplored. This project aims to identify the sequence of events and factors involved in cortical circuit assembly in the developing mouse brain. As such, this project can be broadly divided into three main parts namely lamination, synaptogenesis and maturation of the MGE interneurons specifically. Currently, the exact mechanisms that govern MGE interneurons are still unknown except that it may involve cues that are produced by the pyramidal neurons. Therefore, we aim to use existing transcriptome data of the different neuronal layers coupled with the acquisition of the early- and late- born MGE interneurons transcriptome in order to identify the receptor-ligand pair that is involved in the specific lamination of MGE interneuron. We also aim to understand the sequence of events that occur during synaptogenesis and maturation of MGE interneurons. To achieve this, we will be performing live imaging on organotypic brain slices of sparsely labeled MGE interneurons and by selectively killing specific classes of interneurons in order to determine the effect of these cells on the maturation of the parvalbumin-expressing interneuron. Altogether, this proposed project will give a better insights into the factors and mechanisms underlying cortical circuit assembly in the developing brain and will pave the way for a better understanding into the aetiology of certain neurodevelopmental disorders.


year authors and title journal last update
List of publications.
2019 Fong Kuan Wong, Oscar Marín
Developmental Cell Death in the Cerebral Cortex
published pages: 523-542, ISSN: 1081-0706, DOI: 10.1146/annurev-cellbio-100818-125204
Annual Review of Cell and Developmental Biology 35/1 2020-02-07
2018 Fong Kuan Wong, Kinga Bercsenyi, Varun Sreenivasan, Adrián Portalés, Marian Fernández-Otero, Oscar Marín
Pyramidal cell regulation of interneuron survival sculpts cortical networks
published pages: 668-673, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0139-6
Nature 557/7707 2020-02-07

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The information about "CORCIR" are provided by the European Opendata Portal: CORDIS opendata.

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