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Characterisation of a Novel Pathway for Lignin Fragment Degradation in Rhodococcus jostii

Total Cost €


EC-Contrib. €






Project "PELIG" data sheet

The following table provides information about the project.


Organization address
address: Kirby Corner Road - University House
postcode: CV4 8UW

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-10-06   to  2018-10-05


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF WARWICK UK (COVENTRY) coordinator 183˙454.00


 Project objective

Lignin, composed of phenylpropanoic units, represents an attractive raw material for renewable aromatic chemicals. Lignin valorisation instead of petrochemical industry for chemicals production is a hot research area in green chemistry. Microorganisms have been proven to evolve metabolic pathways that enable the break-down of lignin; however, this lignin-to-chemicals bioconversion by both fungi and bacteria lacks essential attributes to commercial implementation. In the forefront, “omics” research has pointed out potential target genes and enzymes for manipulation, leading to more applied lignin bioconversion studies. Bacterial lignin metabolism is attracting more attention due to its relatively simple protein expression and genetic modification compared to fungi, which provides a potential application of a targeted pathway engineering strategy for diversified lignin-derived byproducts accumulation and yield enhancement. Hence, the discovery of unknown lignin metabolic pathways and gene products in bacteria is of importance. In this context, the current proposed research will explore and manipulate a novel lignin metabolic pathway - transketolase lignin degradation pathway - in Rhodococcus for lignin-based renewable chemicals production by using a synthetic biology approach. The goal will be achieved by pursuing the following two objectives: 1) elucidation and characterization of the novel enzyme encoded with tklX and evaluation of its activity reacted with lignin model compounds as transketolase; 2) targeted gene deletion for pathway engineering in genetically tractable hosts to manipulate lignin breakdown. The results of this study will therefore establish a promising foundation for production of lignin-derived chemicals from renewable feedstocks via catabolic pathways. Meanwhile, the Action will clearly provide the Applicant with unique opportunities to reach a position of professional maturity.

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The information about "PELIG" are provided by the European Opendata Portal: CORDIS opendata.

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