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MolecularEVOLUTION SIGNED

Molecular Evolution of the Primary Structure of Single Chain Polymer Nanoparticles via Dynamic Covalent Chemistry

Total Cost €

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EC-Contrib. €

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Partnership

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 MolecularEVOLUTION project word cloud

Explore the words cloud of the MolecularEVOLUTION project. It provides you a very rough idea of what is the project "MolecularEVOLUTION" about.

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Project "MolecularEVOLUTION" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT EINDHOVEN 

Organization address
address: GROENE LOPER 3
city: EINDHOVEN
postcode: 5612 AE
website: www.tue.nl/en

contact info
title: n.a.
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Netherlands [NL]
 Project website http://www.meijerlab.nl
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) coordinator 165˙598.00

Map

 Project objective

Cancer continues to be a major cause of death worldwide. While many drugs can reduce the size of tumors, their side effects commonly outweigh their benefits when the drug is administered by conventional methods. One promising approach to overcome this issue is to employ a synthetic enzyme to activate a prodrug into an active drug via a bioorthogonal reaction at the site of a tumor within a patient. Recent work by the group of Prof. E. W. Meijer at the Eindhoven University of Technology on amphiphilic polymers with pendant “sticky” hydrogen bonding moieties and pendant catalytic centers represents state-of-the-art synthetic enzymes. When these polymers are dissolved in dilute aqueous solutions, individual chains fold to form single chain polymer nanoparticles (SCPNs). The folding is thermodynamically driven by hydrophobic interactions and the dynamic aggregation of the “sticky” moieties. Although current SCPNs catalyze bioorthogonal reactions in water, they do not have well-defined high order structure like natural enzymes, instead exhibiting non-cooperative folding and open, elliptical structures. This lack of well-defined high order structure is due to a lack of polymer sequence control, as SCPNs reported to date are random or block copolymers. As a postdoctoral fellow in the Meijer group, I propose to make a new generation of biocompatible SCPNs that feature an aliphatic polycarbonate backbone that undergoes dynamic covalent chemistry in conjunction with the dynamic aggregation of the “sticky” pendant units to “molecularly evolve” the SCPN’s primary structure. This strategy will allow SCPNs to “correct” non-optimal sequences by giving each polymer chain the ability to reshuffle its primary structure, ultimately allowing the SCPNs to achieve lower energy folding states. I predict that the hydrophobic cores of the resulting evolved SCPNs will be more enzyme-like and thus better suited for catalysis and targeted drug therapy applications.

 Publications

year authors and title journal last update
List of publications.
2018 Beatrice Adelizzi, Antonio Aloi, Nathan J. Van Zee, Anja R. A. Palmans, E. W. Meijer, and Ilja K. Voets
Painting supramolecular polymers in organic solvents by super-resolution microscopy
published pages: , ISSN: 1936-0851, DOI:
ACS Nano 2019-06-13
2018 Nathan J. Van Zee, Beatrice Adelizzi, Mathijs F. J. Mabesoone, Xiao Meng, Antonio Aloi, R. Helen Zha, Martin Lutz, Ivo A. W. Filot, Anja R. A. Palmans, E. W. Meijer
Potential enthalpic energy of water in oils exploited to control supramolecular structure
published pages: , ISSN: 0028-0836, DOI:
Nature 2019-06-13

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