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EVOL-WNS

Genetic factors contributing to White Nose Syndrome tolerance in North American and European Myotis-bats

Total Cost €

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EC-Contrib. €

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Partnership

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 EVOL-WNS project word cloud

Explore the words cloud of the EVOL-WNS project. It provides you a very rough idea of what is the project "EVOL-WNS" about.

survivors    probably    sampled    north    infection    mechanisms    originates    predict    pseudogymnoascus    damage    epidermal    candidate    destructans    genus    deposited    lucifugus    tolerant    appear    pan    genes    susceptible    survivor    validate    died    quartile    hibernation    fat    prematurely    genetic    consume    suitable    survival    gene    infected    profiles    observe    transferable    2007    america    orthologs    detection    samples    tolerance    onset    time    bottleneck    populations    disease    2006    arouse    syndrome    researcher    wildlife    population    wns    existed    conservation    strategies    pd    fungus    winter    pathogens    tenured    frequently    sweeps    bats    gain    differ    archived    million    nose    poolseq    causes    psychrophilic    skills    bat    species    co    dna    transcriptomes    remnant    position    unknown    brandtii    understand    rates    reserves    once    last    selective    white    myotis    caused    training    fungal   

Project "EVOL-WNS" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF LIVERPOOL 

Organization address
address: BROWNLOW HILL 765 FOUNDATION BUILDING
city: LIVERPOOL
postcode: L69 7ZX
website: www.liverpool.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.liverpool.ac.uk
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2018-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) coordinator 183˙454.00

Map

 Project objective

White-Nose Syndrome (WNS) is a fungal disease affecting bats during hibernation. Since 2007, an estimated 6 million bats in North-America have died of the infection, which causes bats to prematurely consume the fat reserves deposited for winter hibernation. The infected bats arouse from hibernation more frequently; probably due to epidermal damage caused by Pseudogymnoascus destructans (Pd), a psychrophilic fungus. Pd originates from Europe, however, European bats appear to be tolerant to the infection. Tolerance has also been recently observed in remnant populations in the U.S, where these WNS-survivors have co-existed with the fungus since 2006. The mechanisms leading to adaptation or tolerance remain unknown. Here we aim to investigate genetic factors that may contribute to Pd-tolerance in the most frequently infected genus of bats, Myotis. By using DNA-samples from two Myotis species from North America (Myotis lucifugus) and Europe (Myotis brandtii), we should observe selection in gene orthologs between European bats and bats in WNS-survivor populations. The selection profiles should differ from archived WNS-susceptible bats, sampled before the onset of the wildlife disease. Once we have identified suitable candidate genes with PoolSeq and detection of selective sweeps, we will validate the results by comparing the transcriptomes of both infected WNS-susceptible and infected WNS-survivor M. lucifugus and infected M. brandtii in the last quartile of their hibernation. The results will demonstrate the pan-species and population-wide effects of a real-time bottleneck and help us understand the mechanisms promoting tolerance to the pathogens. The proposal will provide training in technical and transferable skills to allow the experienced researcher to gain a tenured position and achieve impact through conservation measures that help predict bat population survival rates and hibernation strategies.

 Publications

year authors and title journal last update
List of publications.
2018 Eero J. Vesterinen, Anna I. E. Puisto, Anna S. Blomberg, Thomas M. Lilley
Table for five, please: Dietary partitioning in boreal bats
published pages: 10914-10937, ISSN: 2045-7758, DOI: 10.1002/ece3.4559
Ecology and Evolution 8/22 2019-05-23
2019 Gonzalo Ossa, Joseph S. Johnson, Anna I. E. Puisto, Veikko Rinne, Ilari E. Sääksjärvi, Austin Waag, Eero J. Vesterinen, Thomas M. Lilley
The Klingon batbugs: Morphological adaptations in the primitive bat bugs, Bucimex chilensis and Primicimex cavernis , including updated phylogeny of Cimicidae
published pages: , ISSN: 2045-7758, DOI: 10.1002/ece3.4846
Ecology and Evolution 2019-05-23
2018 Thomas M. Lilley, Jani Anttila, Lasse Ruokolainen
Landscape structure and ecology influence the spread of a bat fungal disease
published pages: 2483-2496, ISSN: 0269-8463, DOI: 10.1111/1365-2435.13183
Functional Ecology 32/11 2019-05-23

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