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EVOL-WNS

Genetic factors contributing to White Nose Syndrome tolerance in North American and European Myotis-bats

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EVOL-WNS project word cloud

Explore the words cloud of the EVOL-WNS project. It provides you a very rough idea of what is the project "EVOL-WNS" about.

appear conservation pseudogymnoascus died detection unknown last wns america mechanisms transcriptomes genus wildlife disease observe sweeps pan profiles survivors winter skills epidermal bats rates 2007 training million suitable survivor hibernation fungus sampled strategies infection pd lucifugus originates reserves susceptible white brandtii archived samples species onset psychrophilic fungal bat bottleneck tolerant infected understand caused probably differ survival tenured remnant candidate orthologs deposited population nose myotis co arouse genes damage syndrome consume 2006 north transferable existed dna causes selective once researcher time populations destructans validate pathogens gene fat quartile predict prematurely genetic frequently tolerance position gain poolseq

Project "EVOL-WNS" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF LIVERPOOL Organization address address: BROWNLOW HILL 765 FOUNDATION BUILDING city: LIVERPOOL postcode: L69 7ZX website: www.liverpool.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.liverpool.ac.uk
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-11-01 to 2018-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF LIVERPOOL THE UNIVERSITY OF LIVERPOOL Organization address address: BROWNLOW HILL 765 FOUNDATION BUILDING city: LIVERPOOL postcode: L69 7ZX website: www.liverpool.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LIVERPOOL)	coordinator	183˙454.00

Map

Project objective

White-Nose Syndrome (WNS) is a fungal disease affecting bats during hibernation. Since 2007, an estimated 6 million bats in North-America have died of the infection, which causes bats to prematurely consume the fat reserves deposited for winter hibernation. The infected bats arouse from hibernation more frequently; probably due to epidermal damage caused by Pseudogymnoascus destructans (Pd), a psychrophilic fungus. Pd originates from Europe, however, European bats appear to be tolerant to the infection. Tolerance has also been recently observed in remnant populations in the U.S, where these WNS-survivors have co-existed with the fungus since 2006. The mechanisms leading to adaptation or tolerance remain unknown. Here we aim to investigate genetic factors that may contribute to Pd-tolerance in the most frequently infected genus of bats, Myotis. By using DNA-samples from two Myotis species from North America (Myotis lucifugus) and Europe (Myotis brandtii), we should observe selection in gene orthologs between European bats and bats in WNS-survivor populations. The selection profiles should differ from archived WNS-susceptible bats, sampled before the onset of the wildlife disease. Once we have identified suitable candidate genes with PoolSeq and detection of selective sweeps, we will validate the results by comparing the transcriptomes of both infected WNS-susceptible and infected WNS-survivor M. lucifugus and infected M. brandtii in the last quartile of their hibernation. The results will demonstrate the pan-species and population-wide effects of a real-time bottleneck and help us understand the mechanisms promoting tolerance to the pathogens. The proposal will provide training in technical and transferable skills to allow the experienced researcher to gain a tenured position and achieve impact through conservation measures that help predict bat population survival rates and hibernation strategies.

Publications

List of publications.
year	authors and title	journal	last update
2018	Eero J. Vesterinen, Anna I. E. Puisto, Anna S. Blomberg, Thomas M. Lilley Table for five, please: Dietary partitioning in boreal bats published pages: 10914-10937, ISSN: 2045-7758, DOI: 10.1002/ece3.4559	Ecology and Evolution 8/22	2019-05-23
2019	Gonzalo Ossa, Joseph S. Johnson, Anna I. E. Puisto, Veikko Rinne, Ilari E. SÃ¤Ã¤ksjÃ¤rvi, Austin Waag, Eero J. Vesterinen, Thomas M. Lilley The Klingon batbugs: Morphological adaptations in the primitive bat bugs, Bucimex chilensis and Primicimex cavernis , including updated phylogeny of Cimicidae published pages: , ISSN: 2045-7758, DOI: 10.1002/ece3.4846	Ecology and Evolution	2019-05-23
2018	Thomas M. Lilley, Jani Anttila, Lasse Ruokolainen Landscape structure and ecology influence the spread of a bat fungal disease published pages: 2483-2496, ISSN: 0269-8463, DOI: 10.1111/1365-2435.13183	Functional Ecology 32/11	2019-05-23

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