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EVOL-WNS

Genetic factors contributing to White Nose Syndrome tolerance in North American and European Myotis-bats

Total Cost €

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EC-Contrib. €

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Partnership

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 EVOL-WNS project word cloud

Explore the words cloud of the EVOL-WNS project. It provides you a very rough idea of what is the project "EVOL-WNS" about.

time    genes    gain    fungal    2006    infection    understand    populations    million    differ    nose    sampled    bats    remnant    susceptible    genus    america    existed    pathogens    infected    myotis    caused    species    last    archived    transferable    hibernation    pan    training    consume    observe    validate    dna    prematurely    disease    suitable    position    survival    co    brandtii    sweeps    candidate    tolerance    2007    pseudogymnoascus    psychrophilic    onset    frequently    causes    bottleneck    died    tolerant    reserves    wildlife    once    lucifugus    unknown    wns    deposited    profiles    genetic    researcher    detection    winter    fat    skills    gene    rates    samples    transcriptomes    white    arouse    survivor    orthologs    appear    mechanisms    poolseq    tenured    probably    syndrome    fungus    destructans    north    bat    population    selective    strategies    epidermal    originates    pd    damage    quartile    conservation    predict    survivors   

Project "EVOL-WNS" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF LIVERPOOL 

Organization address
address: BROWNLOW HILL 765 FOUNDATION BUILDING
city: LIVERPOOL
postcode: L69 7ZX
website: www.liverpool.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.liverpool.ac.uk
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2018-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) coordinator 183˙454.00

Map

 Project objective

White-Nose Syndrome (WNS) is a fungal disease affecting bats during hibernation. Since 2007, an estimated 6 million bats in North-America have died of the infection, which causes bats to prematurely consume the fat reserves deposited for winter hibernation. The infected bats arouse from hibernation more frequently; probably due to epidermal damage caused by Pseudogymnoascus destructans (Pd), a psychrophilic fungus. Pd originates from Europe, however, European bats appear to be tolerant to the infection. Tolerance has also been recently observed in remnant populations in the U.S, where these WNS-survivors have co-existed with the fungus since 2006. The mechanisms leading to adaptation or tolerance remain unknown. Here we aim to investigate genetic factors that may contribute to Pd-tolerance in the most frequently infected genus of bats, Myotis. By using DNA-samples from two Myotis species from North America (Myotis lucifugus) and Europe (Myotis brandtii), we should observe selection in gene orthologs between European bats and bats in WNS-survivor populations. The selection profiles should differ from archived WNS-susceptible bats, sampled before the onset of the wildlife disease. Once we have identified suitable candidate genes with PoolSeq and detection of selective sweeps, we will validate the results by comparing the transcriptomes of both infected WNS-susceptible and infected WNS-survivor M. lucifugus and infected M. brandtii in the last quartile of their hibernation. The results will demonstrate the pan-species and population-wide effects of a real-time bottleneck and help us understand the mechanisms promoting tolerance to the pathogens. The proposal will provide training in technical and transferable skills to allow the experienced researcher to gain a tenured position and achieve impact through conservation measures that help predict bat population survival rates and hibernation strategies.

 Publications

year authors and title journal last update
List of publications.
2018 Eero J. Vesterinen, Anna I. E. Puisto, Anna S. Blomberg, Thomas M. Lilley
Table for five, please: Dietary partitioning in boreal bats
published pages: 10914-10937, ISSN: 2045-7758, DOI: 10.1002/ece3.4559
Ecology and Evolution 8/22 2019-05-23
2019 Gonzalo Ossa, Joseph S. Johnson, Anna I. E. Puisto, Veikko Rinne, Ilari E. Sääksjärvi, Austin Waag, Eero J. Vesterinen, Thomas M. Lilley
The Klingon batbugs: Morphological adaptations in the primitive bat bugs, Bucimex chilensis and Primicimex cavernis , including updated phylogeny of Cimicidae
published pages: , ISSN: 2045-7758, DOI: 10.1002/ece3.4846
Ecology and Evolution 2019-05-23
2018 Thomas M. Lilley, Jani Anttila, Lasse Ruokolainen
Landscape structure and ecology influence the spread of a bat fungal disease
published pages: 2483-2496, ISSN: 0269-8463, DOI: 10.1111/1365-2435.13183
Functional Ecology 32/11 2019-05-23

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