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RECORDER

Rare Earth based Upconversion Luminescent Nanomaterials as novel bioprobes for the detection of cardiac biomarkers

Total Cost €

0

EC-Contrib. €

0

Partnership

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 RECORDER project word cloud

Explore the words cloud of the RECORDER project. It provides you a very rough idea of what is the project "RECORDER" about.

resonance    methodology    manner    protein    detect    underpinning    earth    heart    phospholipase    sensitivity    ctni    wavelengths    diseases    causes    biomarkers    troponin    biophotonic    binding    countries    accurate    sensor    laser    poc    01ng    health    cardiac    technologies    rare    deaths    biomarker    transfer    doped    excited    acid    point    sensitive    absorptions    900    nm    demands    signal    concentrations    detection    gt    longer    nanoparticle    ml    cardiovascular    hospitals    fatty    efficient    uc    lp    revolutionize    fluorescence    investigation    infarction    acceptor    leads    nanoparticles    care    reported    mb    asian    give    nature    confidence    simultaneous    pla2    autofluorescence    incapable    primary    india    multiple    myocardial    energy    upconversion    conventional    fabp    specificity    small    infrared    diagnosis    speed    dysfunction    myoglobin    re    premature    patient    acute    mainly    cvd    overcome    excitation    fret    recorder    unambiguous    platform    measureable    visible    ultraviolet    stroke    lipoprotein    noise    ami   

Project "RECORDER" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-07-13   to  2018-08-25

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 195˙454.00

Map

 Project objective

Cardiovascular diseases (CVD) which include acute myocardial infarction (AMI) and stroke are the main causes of premature deaths in the EU and in Asian countries including India. Researchers have identified and reported that biomarkers can provide advance information about cardiac dysfunction which leads to acute myocardial infarction (AMI) and stroke. However technologies for sensitive and accurate detection of CVD biomarkers are not available. The nature of the CVD also demands efficient simultaneous detection of these biomarkers that the current approaches are incapable of. RECORDER aims to develop a novel biophotonic sensor methodology and technology concept for unambiguous detection of multiple biomarkers, which give confidence in the early diagnosis of CVD that in the longer term can be developed for point of care (POC) applications. The underpinning sensor principle in RECORDER is based on measureable fluorescence resonance energy transfer (FRET) from rare earth (RE) doped nanoparticles under infrared laser (wavelengths >900 nm) excitation known as upconversion fluorescence to acceptor nanoparticle with specific absorptions in the presence of very small concentrations (1-0.01ng/mL) of biomarkers. The investigation of parameters including sensitivity, specificity and speed of detection of CVD biomarkers such as cardiac troponin (mainly, cTnI), heart fatty acid binding protein (H-FABP) lipoprotein-associated phospholipase A(2) (Lp-PLA2) and myoglobin (Mb) based on upconversion and upconversion fluorescence energy transfer (UC-FRET) to overcome large noise in signal due to autofluorescence if excited with ultraviolet or visible wavelengths as in conventional FRET, will be a highly novel approach. UC-FRET applied to detect CVD biomarkers in this project will lead to a novel platform technology that will revolutionize biomarker analysis in a cost effective manner for better patient management in hospitals, primary health care and in the long term at POC.

 Publications

year authors and title journal last update
List of publications.
2018 Padmaja Parameswaran Nampi, Alexandre Vakurov, Lewis E. Mackenzie, Nigel S. Scrutton, Paul A. Millner, Gin Jose, Sikha Saha
Selective cellular imaging with lanthanide based upconversion nanoparticles
published pages: e201800256, ISSN: 1864-063X, DOI: 10.1002/jbio.201800256
Journal of Biophotonics 2019-04-18

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