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RECORDER

Rare Earth based Upconversion Luminescent Nanomaterials as novel bioprobes for the detection of cardiac biomarkers

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Outcomes and results

 RECORDER project word cloud

Explore the words cloud of the RECORDER project. It provides you a very rough idea of what is the project "RECORDER" about.

diagnosis    ultraviolet    wavelengths    acceptor    signal    revolutionize    ml    lp    simultaneous    unambiguous    asian    sensitivity    countries    underpinning    detection    lipoprotein    absorptions    give    sensitive    deaths    visible    troponin    acute    causes    overcome    heart    excitation    diseases    fabp    01ng    phospholipase    biomarkers    fatty    measureable    re    reported    mainly    resonance    primary    uc    ctni    earth    mb    pla2    patient    laser    stroke    small    nanoparticle    health    protein    myoglobin    excited    confidence    ami    fluorescence    detect    longer    cardiovascular    platform    doped    poc    accurate    recorder    care    india    demands    biophotonic    nanoparticles    noise    cvd    specificity    binding    concentrations    dysfunction    transfer    energy    rare    autofluorescence    point    gt    upconversion    fret    900    biomarker    methodology    acid    investigation    manner    nature    hospitals    multiple    myocardial    cardiac    infarction    leads    efficient    nm    conventional    technologies    infrared    speed    premature    sensor    incapable   

Project "RECORDER" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-07-13   to  2018-08-25

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 195˙454.00

Map

 Project objective

Cardiovascular diseases (CVD) which include acute myocardial infarction (AMI) and stroke are the main causes of premature deaths in the EU and in Asian countries including India. Researchers have identified and reported that biomarkers can provide advance information about cardiac dysfunction which leads to acute myocardial infarction (AMI) and stroke. However technologies for sensitive and accurate detection of CVD biomarkers are not available. The nature of the CVD also demands efficient simultaneous detection of these biomarkers that the current approaches are incapable of. RECORDER aims to develop a novel biophotonic sensor methodology and technology concept for unambiguous detection of multiple biomarkers, which give confidence in the early diagnosis of CVD that in the longer term can be developed for point of care (POC) applications. The underpinning sensor principle in RECORDER is based on measureable fluorescence resonance energy transfer (FRET) from rare earth (RE) doped nanoparticles under infrared laser (wavelengths >900 nm) excitation known as upconversion fluorescence to acceptor nanoparticle with specific absorptions in the presence of very small concentrations (1-0.01ng/mL) of biomarkers. The investigation of parameters including sensitivity, specificity and speed of detection of CVD biomarkers such as cardiac troponin (mainly, cTnI), heart fatty acid binding protein (H-FABP) lipoprotein-associated phospholipase A(2) (Lp-PLA2) and myoglobin (Mb) based on upconversion and upconversion fluorescence energy transfer (UC-FRET) to overcome large noise in signal due to autofluorescence if excited with ultraviolet or visible wavelengths as in conventional FRET, will be a highly novel approach. UC-FRET applied to detect CVD biomarkers in this project will lead to a novel platform technology that will revolutionize biomarker analysis in a cost effective manner for better patient management in hospitals, primary health care and in the long term at POC.

 Publications

year authors and title journal last update
List of publications.
2018 Padmaja Parameswaran Nampi, Alexandre Vakurov, Lewis E. Mackenzie, Nigel S. Scrutton, Paul A. Millner, Gin Jose, Sikha Saha
Selective cellular imaging with lanthanide based upconversion nanoparticles
published pages: e201800256, ISSN: 1864-063X, DOI: 10.1002/jbio.201800256 		Journal of Biophotonics 2019-04-18

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The information about "RECORDER" are provided by the European Opendata Portal: CORDIS opendata.

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