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RECORDER

Rare Earth based Upconversion Luminescent Nanomaterials as novel bioprobes for the detection of cardiac biomarkers

Total Cost €

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EC-Contrib. €

0

Partnership

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 Outcomes and results

 RECORDER project word cloud

Explore the words cloud of the RECORDER project. It provides you a very rough idea of what is the project "RECORDER" about.

sensor    acid    cardiac    ctni    900    measureable    infrared    lipoprotein    ultraviolet    patient    accurate    fluorescence    nm    biomarker    uc    detect    ml    technologies    myoglobin    phospholipase    primary    infarction    troponin    biomarkers    recorder    causes    manner    fabp    conventional    nature    diseases    acute    dysfunction    mb    biophotonic    revolutionize    doped    re    reported    gt    countries    hospitals    point    nanoparticle    laser    overcome    premature    fret    pla2    specificity    methodology    incapable    autofluorescence    underpinning    acceptor    speed    small    investigation    poc    heart    concentrations    excited    cvd    transfer    give    mainly    signal    diagnosis    cardiovascular    unambiguous    multiple    earth    energy    efficient    myocardial    upconversion    rare    asian    detection    sensitive    resonance    platform    demands    absorptions    deaths    noise    care    binding    health    stroke    simultaneous    confidence    india    longer    nanoparticles    leads    excitation    visible    lp    sensitivity    protein    ami    fatty    wavelengths    01ng   

Project "RECORDER" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-07-13   to  2018-08-25

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 195˙454.00

Map

 Project objective

Cardiovascular diseases (CVD) which include acute myocardial infarction (AMI) and stroke are the main causes of premature deaths in the EU and in Asian countries including India. Researchers have identified and reported that biomarkers can provide advance information about cardiac dysfunction which leads to acute myocardial infarction (AMI) and stroke. However technologies for sensitive and accurate detection of CVD biomarkers are not available. The nature of the CVD also demands efficient simultaneous detection of these biomarkers that the current approaches are incapable of. RECORDER aims to develop a novel biophotonic sensor methodology and technology concept for unambiguous detection of multiple biomarkers, which give confidence in the early diagnosis of CVD that in the longer term can be developed for point of care (POC) applications. The underpinning sensor principle in RECORDER is based on measureable fluorescence resonance energy transfer (FRET) from rare earth (RE) doped nanoparticles under infrared laser (wavelengths >900 nm) excitation known as upconversion fluorescence to acceptor nanoparticle with specific absorptions in the presence of very small concentrations (1-0.01ng/mL) of biomarkers. The investigation of parameters including sensitivity, specificity and speed of detection of CVD biomarkers such as cardiac troponin (mainly, cTnI), heart fatty acid binding protein (H-FABP) lipoprotein-associated phospholipase A(2) (Lp-PLA2) and myoglobin (Mb) based on upconversion and upconversion fluorescence energy transfer (UC-FRET) to overcome large noise in signal due to autofluorescence if excited with ultraviolet or visible wavelengths as in conventional FRET, will be a highly novel approach. UC-FRET applied to detect CVD biomarkers in this project will lead to a novel platform technology that will revolutionize biomarker analysis in a cost effective manner for better patient management in hospitals, primary health care and in the long term at POC.

 Publications

year authors and title journal last update
List of publications.
2018 Padmaja Parameswaran Nampi, Alexandre Vakurov, Lewis E. Mackenzie, Nigel S. Scrutton, Paul A. Millner, Gin Jose, Sikha Saha
Selective cellular imaging with lanthanide based upconversion nanoparticles
published pages: e201800256, ISSN: 1864-063X, DOI: 10.1002/jbio.201800256 		Journal of Biophotonics 2019-04-18

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The information about "RECORDER" are provided by the European Opendata Portal: CORDIS opendata.

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