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RECORDER

Rare Earth based Upconversion Luminescent Nanomaterials as novel bioprobes for the detection of cardiac biomarkers

Total Cost €

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EC-Contrib. €

0

Partnership

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 Outcomes and results

 RECORDER project word cloud

Explore the words cloud of the RECORDER project. It provides you a very rough idea of what is the project "RECORDER" about.

detection    troponin    specificity    biophotonic    revolutionize    acid    gt    upconversion    01ng    longer    detect    infarction    biomarker    countries    resonance    demands    transfer    lipoprotein    multiple    protein    poc    care    premature    unambiguous    pla2    excited    sensor    myocardial    uc    dysfunction    confidence    health    underpinning    fluorescence    cardiac    causes    signal    ultraviolet    sensitive    diagnosis    cvd    mainly    binding    phospholipase    overcome    patient    ctni    recorder    nanoparticles    cardiovascular    absorptions    give    biomarkers    speed    energy    leads    methodology    conventional    india    ml    incapable    autofluorescence    noise    measureable    acute    doped    point    fret    manner    investigation    efficient    technologies    nanoparticle    heart    laser    rare    deaths    re    diseases    sensitivity    concentrations    stroke    lp    accurate    small    fatty    platform    myoglobin    mb    asian    hospitals    nature    infrared    acceptor    wavelengths    fabp    visible    ami    reported    excitation    simultaneous    nm    earth    primary    900   

Project "RECORDER" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-07-13   to  2018-08-25

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 195˙454.00

Map

 Project objective

Cardiovascular diseases (CVD) which include acute myocardial infarction (AMI) and stroke are the main causes of premature deaths in the EU and in Asian countries including India. Researchers have identified and reported that biomarkers can provide advance information about cardiac dysfunction which leads to acute myocardial infarction (AMI) and stroke. However technologies for sensitive and accurate detection of CVD biomarkers are not available. The nature of the CVD also demands efficient simultaneous detection of these biomarkers that the current approaches are incapable of. RECORDER aims to develop a novel biophotonic sensor methodology and technology concept for unambiguous detection of multiple biomarkers, which give confidence in the early diagnosis of CVD that in the longer term can be developed for point of care (POC) applications. The underpinning sensor principle in RECORDER is based on measureable fluorescence resonance energy transfer (FRET) from rare earth (RE) doped nanoparticles under infrared laser (wavelengths >900 nm) excitation known as upconversion fluorescence to acceptor nanoparticle with specific absorptions in the presence of very small concentrations (1-0.01ng/mL) of biomarkers. The investigation of parameters including sensitivity, specificity and speed of detection of CVD biomarkers such as cardiac troponin (mainly, cTnI), heart fatty acid binding protein (H-FABP) lipoprotein-associated phospholipase A(2) (Lp-PLA2) and myoglobin (Mb) based on upconversion and upconversion fluorescence energy transfer (UC-FRET) to overcome large noise in signal due to autofluorescence if excited with ultraviolet or visible wavelengths as in conventional FRET, will be a highly novel approach. UC-FRET applied to detect CVD biomarkers in this project will lead to a novel platform technology that will revolutionize biomarker analysis in a cost effective manner for better patient management in hospitals, primary health care and in the long term at POC.

 Publications

year authors and title journal last update
List of publications.
2018 Padmaja Parameswaran Nampi, Alexandre Vakurov, Lewis E. Mackenzie, Nigel S. Scrutton, Paul A. Millner, Gin Jose, Sikha Saha
Selective cellular imaging with lanthanide based upconversion nanoparticles
published pages: e201800256, ISSN: 1864-063X, DOI: 10.1002/jbio.201800256 		Journal of Biophotonics 2019-04-18

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The information about "RECORDER" are provided by the European Opendata Portal: CORDIS opendata.

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