EU H2020 Project "GENDER-CF (Gender-related differences in expression of microRNAs in cystic fibrosis)": description, partecipants, costs and EC-fundings

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GENDER-CF project word cloud

Explore the words cloud of the GENDER-CF project. It provides you a very rough idea of what is the project "GENDER-CF" about.

morbidity secondments data strengthen independence tumour epithelial altered network genes female laboratory qpcr immunity college ireland mirna immunology equipped sex transferable university disadvantage airway cell statistically disease active cystic plays royal supervision cf mirnas flow public renowned patients implicated necrosis microrna encoding expertise function engagement diversify collaborative lung team class ing traf6 accelerating defective tlr4 centre predicted professionally netherlands combine infective ongoing progression teams gender ion therapies fellowship pulmonary leiden cornerstone innate germany regulation progressive form consequent estrogen inflammation females toll competencies rcsi medical expand student aid world richly innovative acquisition applicable hormone exacerbations career channel pi noted skills survival respiratory host surgeons expression gap inflammatory heidelberg death cytometry hereditary am fibrosis keen position mediators receptor

Project "GENDER-CF" data sheet

The following table provides information about the project.

Coordinator	ROYAL COLLEGE OF SURGEONS IN IRELAND Organization address address: Saint Stephen's Green 123 city: DUBLIN postcode: 2 website: www.rcsi.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Project website	https://www.researchgate.net/project/Gender-related-differences-in-expression-of-microRNAs-in-cystic-fibrosis
Total cost	175˙866 €
EC max contribution	175˙866 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-09-01 to 2019-08-31

#	participants	country	role	EC contrib. [€]
1	ROYAL COLLEGE OF SURGEONS IN IRELAND	IE (DUBLIN)	coordinator	175˙866.00

ROYAL COLLEGE OF SURGEONS IN IRELAND

IE (DUBLIN)

coordinator

175˙866.00

Project objective

Cystic fibrosis (CF) is a hereditary disease involving a defective ion channel, resulting in altered epithelial cell function and consequent infective/inflammatory airway exacerbations. Progressive loss of lung function is the leading cause of death in CF patients. It is statistically noted that females have a disadvantage in survival and morbidity; this is commonly referred to as the CF gender gap. Recent studies have implicated the female sex hormone, estrogen, in this gender gap. CF patients show altered microRNA expression and some of the affected miRNAs are predicted to target genes encoding key inflammatory mediators such as Toll-like receptor 4 (TLR4) and tumour necrosis factor a receptor associated factor-6 (TRAF6). This highly innovative proposal, to be implemented at the Royal College of Surgeons Ireland (RCSI), aims to study the regulation of key miRNAs by estrogen and investigate if this plays a role in the CF gender gap. I will combine my own expertise in pulmonary innate immunity with the host PI’s world-class knowledge of CF and miRNA research. The research will further our understanding of inflammation in CF to aid development of better therapies. I will develop professionally as I: a) diversify my competencies through the acquisition of new laboratory skills (e.g. qPCR, flow cytometry), b) strengthen my transferable skills (e.g. project management, public engagement, data dissemination) and c) expand my collaborative network through secondments to other world-renowned research teams in Leiden University Medical Centre, Netherlands and University of Heidelberg, Germany. I will contribute richly to research at RCSI as I am already equipped with skills applicable to ongoing work in the team and am keen to take an active role in student supervision. The opportunities carried by this fellowship will form the cornerstone of my career, accelerating my progression towards my goal of achieving a position of independence in respiratory immunology research.

Publications

List of publications.
year	authors and title	journal	last update
2018	Arlene M.A. Glasgow, Chiara De Santi, Catherine M. Greene Non-coding RNA in cystic fibrosis published pages: 619-630, ISSN: 0300-5127, DOI: 10.1042/bst20170469	Biochemical Society Transactions 46/3	2020-01-29

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