Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. gender-cf

GENDER-CF

Gender-related differences in expression of microRNAs in cystic fibrosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0
 Outcomes and results

 GENDER-CF project word cloud

Explore the words cloud of the GENDER-CF project. It provides you a very rough idea of what is the project "GENDER-CF" about.

diversify    accelerating    innovative    class    cell    females    strengthen    disadvantage    renowned    disease    engagement    expertise    network    college    expand    fellowship    cornerstone    student    acquisition    transferable    flow    function    plays    patients    royal    germany    inflammatory    professionally    progressive    defective    statistically    supervision    exacerbations    microrna    heidelberg    netherlands    tlr4    progression    ongoing    teams    hormone    host    expression    am    cytometry    centre    mirna    consequent    leiden    encoding    therapies    data    cf    mirnas    team    female    infective    ing    ion    active    predicted    qpcr    channel    epithelial    receptor    sex    hereditary    position    aid    immunology    respiratory    collaborative    medical    ireland    applicable    lung    world    combine    gender    toll    genes    career    equipped    skills    independence    form    survival    inflammation    necrosis    estrogen    secondments    rcsi    cystic    implicated    traf6    public    pi    airway    mediators    altered    fibrosis    richly    innate    laboratory    regulation    pulmonary    immunity    death    gap    noted    tumour    surgeons    keen    competencies    university    morbidity   

Project "GENDER-CF" data sheet

The following table provides information about the project.

Coordinator		 ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Ireland [IE]
 Project website https://www.researchgate.net/project/Gender-related-differences-in-expression-of-microRNAs-in-cystic-fibrosis
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 175˙866.00

Map

 Project objective

Cystic fibrosis (CF) is a hereditary disease involving a defective ion channel, resulting in altered epithelial cell function and consequent infective/inflammatory airway exacerbations. Progressive loss of lung function is the leading cause of death in CF patients. It is statistically noted that females have a disadvantage in survival and morbidity; this is commonly referred to as the CF gender gap. Recent studies have implicated the female sex hormone, estrogen, in this gender gap. CF patients show altered microRNA expression and some of the affected miRNAs are predicted to target genes encoding key inflammatory mediators such as Toll-like receptor 4 (TLR4) and tumour necrosis factor a receptor associated factor-6 (TRAF6). This highly innovative proposal, to be implemented at the Royal College of Surgeons Ireland (RCSI), aims to study the regulation of key miRNAs by estrogen and investigate if this plays a role in the CF gender gap. I will combine my own expertise in pulmonary innate immunity with the host PI’s world-class knowledge of CF and miRNA research. The research will further our understanding of inflammation in CF to aid development of better therapies. I will develop professionally as I: a) diversify my competencies through the acquisition of new laboratory skills (e.g. qPCR, flow cytometry), b) strengthen my transferable skills (e.g. project management, public engagement, data dissemination) and c) expand my collaborative network through secondments to other world-renowned research teams in Leiden University Medical Centre, Netherlands and University of Heidelberg, Germany. I will contribute richly to research at RCSI as I am already equipped with skills applicable to ongoing work in the team and am keen to take an active role in student supervision. The opportunities carried by this fellowship will form the cornerstone of my career, accelerating my progression towards my goal of achieving a position of independence in respiratory immunology research.

 Publications

year authors and title journal last update
List of publications.
2018 Arlene M.A. Glasgow, Chiara De Santi, Catherine M. Greene
Non-coding RNA in cystic fibrosis
published pages: 619-630, ISSN: 0300-5127, DOI: 10.1042/bst20170469 		Biochemical Society Transactions 46/3 2020-01-29

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GENDER-CF" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GENDER-CF" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

LieLowerBounds (2019)

Lower bounds for partial differential operators on compact Lie groups

Read More  

CRAS (2019)

Climate change and Resilience of Agricultural System: an econometric and computational analysis

Read More  

LiverMacRegenCircuit (2020)

Elucidating the role of macrophages in liver regeneration and tissue unit formation

Read More