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EXACT

Identifying biomarkers of Exposure leading to Lung Cancer with Adductomics

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EXACT project word cloud

Explore the words cloud of the EXACT project. It provides you a very rough idea of what is the project "EXACT" about.

understand lc causality onset difficult toxicants data serum elucidation samples compounds smoking human adduct elucidate dna carcinogenesis blood structure markers exposed air responsible adductomics reactive technique proof proteins statistical over cancer cohort serve carcinogens species poorly albumin methylation database span longer carcinogen candidate hypothesise smoke world electrophile carcinogenicity adductome ensemble adducts electrophiles link profiles structural tobacco death composition epic analytical concentrations 20 causing identification 400 mechanisms exposure life bind methodology lung pollution suspected people exact suitable protein status disease causes

Project "EXACT" data sheet

The following table provides information about the project.

Coordinator	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://exposomics-project.eu/.
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-06-01 to 2019-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	195˙454.00

Map

Project objective

Over 20% of death by cancer in the world are due to Lung Cancer (LC). Tobacco, and recently, exposure to air pollution, are considered the main causes for LC, thus specific carcinogens have been only partially identified. The complex composition of tobacco smoke and air pollution makes it difficult to identify the specific compounds responsible for the carcinogenesis process. To understand the mechanisms of LC onset, methods are needed to characterize specific toxicants that people are exposed to. We propose to develop a new method to identify exposure-specific (tobacco or air pollution) markers of LC. This new method is based on the measure of the ensemble of electrophile-carcinogens and human serum albumin adducts in human serum: the Adductome. Electrophiles present in blood are highly reactive species that have been long suspected of causing cancer because of their ability to bind DNA and proteins. Protein adducts provide more suitable markers of exposure as they have a longer life span in the blood and are present in much higher concentrations, but have been poorly investigated. In EXACT we hypothesise that protein-carcinogen electrophiles adducts can be used as markers of LC carcinogenesis and that different markers can be identified for tobacco-induced or air pollution-induced disease. Our objective is to improve the current analytical methodology for adductomics analysis and develop a new methodology for adducts structural identification in order to characterize adduct profiles in 400 samples of human serum from the EPIC cohort. Statistical analyses will be carried out to link adducts profiles to smoking status, air pollution data and methylation profiles. The elucidation of the markers structure will allow us to establish a database of candidate compounds responsible for the carcinogenicity of tobacco and air pollution. EXACT will serve as a proof of concept to develop a novel technique based on the use of the Adductome to elucidate disease causality.

Publications

List of publications.
year	authors and title	journal	last update
2018	Sa Liu, Hasmik Grigoryan, William M. B. Edmands, Sonia Dagnino, Rudy Sinharay, Paul Cullinan, Peter Collins, Kian Fan Chung, Benjamin Barratt, Frank J. Kelly, Paolo Vineis, Stephen M. Rappaport Cys34 Adductomes Differ between Patients with Chronic Lung or Heart Disease and Healthy Controls in Central London published pages: 2307-2313, ISSN: 0013-936X, DOI: 10.1021/acs.est.7b05554	Environmental Science & Technology 52/4	2019-08-08
2019	Sonia Dagnino Anthony Macherone Unraveling the Exposome: A Practical View published pages: , ISSN: , DOI:	Springer	2019-08-08

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