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MITOCHONTACTS SIGNED

Mitochondrial membrane contact sites

Total Cost €

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EC-Contrib. €

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Partnership

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 MITOCHONTACTS project word cloud

Explore the words cloud of the MITOCHONTACTS project. It provides you a very rough idea of what is the project "MITOCHONTACTS" about.

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Project "MITOCHONTACTS" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website http://mayaschuldiner.wixsite.com/schuldinerlab/research
 Total cost 182˙509 €
 EC max contribution 182˙509 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 182˙509.00

Map

 Project objective

Organelles offer separate reaction chambers within a eukaryotic cell, thus expanding cellular metabolic capacity but necessitating mechanisms for interorganellar communication. Mitochondria are key players in cellular metabolism and their dysfunction leads to devastating conditions. Intriguingly, they are largely excluded from vesicular trafficking, creating a mystery of how they can fulfill their functions despite being cut off from these important routes of intracellular crosstalk. Membrane contact sites (CS) are starting to be appreciated as a further, vesicle independent, means of communication between organelles. CS are domains where membranes of distinct organelles are tethered by proteinaceous machineries. Factors tethering mitochondria to the endoplasmic reticulum, the vacuole/lysosome and the plasma membrane are known. Electron microscopy studies suggest existence of several additional mitochondrial CS that are currently unknown at a molecular level. Discovery of the principle of interorganellar crosstalk via CS finally offers a solution to the paradox of mitochondria as metabolic hubs being largely excluded from vesicular traffic. In order to understand how mitochondria are integrated into cellular physiology, we need to know the molecular nature of the entire repertoire of CS, their specific biological roles and their regulation in response to metabolic changes. I will utilize a systematic approach to map the complete spectrum of CS between mitochondria and any other cellular organelle in the most experimentally accessible eukaryotic model organism, the yeast Saccharomyces cerevisiae. My approach relies on creation of a molecular sensor for contact sites and its utilization in high content screens to uncover the tethers, regulators and function of mitochondrial CS. Ultimately, my goal is to build a model describing the integration of mitochondrial behavior into cellular physiology via CS-based mechanisms on a holistic level.

 Publications

year authors and title journal last update
List of publications.
2016 Michal Eisenberg-Bord, Nadav Shai, Maya Schuldiner, Maria Bohnert
A Tether Is a Tether Is a Tether: Tethering at Membrane Contact Sites
published pages: 395-409, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2016.10.022
Developmental Cell 39/4 2019-06-13
2018 Michal Eisenberg-Bord, Muriel Mari, Uri Weill, Eden Rosenfeld-Gur, Ofer Moldavski, Inês G. Castro, Krishnakant G. Soni, Nofar Harpaz, Tim P. Levine, Anthony H. Futerman, Fulvio Reggiori, Vytas A. Bankaitis, Maya Schuldiner, Maria Bohnert
Identification of seipin-linked factors that act as determinants of a lipid droplet subpopulation
published pages: 269-282, ISSN: 0021-9525, DOI: 10.1083/jcb.201704122
The Journal of Cell Biology 217/1 2019-06-13
2018 Ayelén González Montoro, Kathrin Auffarth, Carina Hönscher, Maria Bohnert, Thomas Becker, Bettina Warscheid, Fulvio Reggiori, Martin van der Laan, Florian Fröhlich, Christian Ungermann
Vps39 Interacts with Tom40 to Establish One of Two Functionally Distinct Vacuole-Mitochondria Contact Sites
published pages: 621-636.e7, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2018.05.011
Developmental Cell 45/5 2019-06-13
2017 Maya Schuldiner, Maria Bohnert
A different kind of love – lipid droplet contact sites
published pages: 1188-1196, ISSN: 1388-1981, DOI: 10.1016/j.bbalip.2017.06.005
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1862/10 2019-06-13

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