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EDGE SIGNED

Training network providing cutting-EDGE knowlEDGE on Herpes Virology and Immunology

Total Cost €

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EC-Contrib. €

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Partnership

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Project "EDGE" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://edge-itn.eu
 Total cost 3˙961˙943 €
 EC max contribution 3˙961˙943 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 580˙163.00
2    AARHUS UNIVERSITETSHOSPITAL DK (AARHUS) participant 580˙163.00
3    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) participant 516˙122.00
4    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 510˙748.00
5    HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH DE (BRAUNSCHWEIG) participant 498˙432.00
6    MEDIZINISCHE HOCHSCHULE HANNOVER DE (HANNOVER) participant 498˙432.00
7    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 273˙287.00
8    JANSSEN VACCINES & PREVENTION BV NL (LEIDEN) participant 255˙374.00
9    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 249˙216.00

Map

 Project objective

Herpesviruses are widely spread, and cause life-long infections. Most individuals carry multiple herpesviruses, which can cause severe diseases, especially in children, immunocompromised individuals, and elderly. There are currently no safe vaccines against herpesvirus infections and current treatments are not satisfactory. With new insights into the molecular basis for diseases caused by immunodeficiency, and with the increasing numbers of elderly in Europe, there is now an unmet demand for improved treatments of herpesvirus infections. Combined with the progress in basic herpesvirus research, this calls for education of a new generation of scientists with strong research skills, advanced insights into disease mechanisms, and understanding of how industry brings innovative research into the market. In this application we propose an interactive education program for early stage researchers (ESR) in leading European laboratories, hospitals, and biotech companies. The focus will be on the virology and immunology of herpesvirus infections in the context of basic research as well as application of research-acquired knowledge. Our program will prepare the ESRs to manage goal-oriented interactions between academia, the clinics, and the biotech industry. The ESRs will acquire broad theoretical and methodological expertises involving several sectors to obtain the skills required for overcoming the cultural gaps From Bench to Bedside and From Discovery to Innovation. This can only be achieved through a network-based approach. We propose to develop a platform to educate the next generation of scientists to solve the outstanding problems in prevention and treatment of herpesvirus infections. The ESRs will be ideally trained to translate cutting-edge discoveries to novel products and to innovative treatment serving the European people, and hence to improve handling of present and emerging health challenges, as well as to foster the European biopharmaceutical industry sector.

 Deliverables

List of deliverables.
Recruitment ESRs Documents, reports 2019-05-31 11:52:24
Characterization of SLE phenotypes in mice – and impact on CMV infection Documents, reports 2019-05-31 12:00:46
Draft Periodic Report Documents, reports 2019-05-31 12:00:52
Recruitment Manager Documents, reports 2019-05-31 12:00:47
Mid-term review meeting Documents, reports 2019-05-31 12:00:46
Patent and publications in int. journals starting Documents, reports 2019-05-31 12:00:48
Communication of subject to high school students Documents, reports 2019-05-31 12:00:49

Take a look to the deliverables list in detail:  detailed list of EDGE deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Jonny Hertzog, Antonio Gregorio Dias Junior, Rachel E. Rigby, Claire L. Donald, Alice Mayer, Erdinc Sezgin, Chaojun Song, Boquan Jin, Philip Hublitz, Christian Eggeling, Alain Kohl, Jan Rehwinkel
Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling
published pages: , ISSN: 0014-2980, DOI: 10.1002/eji.201847483
European Journal of Immunology 2019-07-08
2018 P. Praest, R.D. Luteijn, I.G.J. Brak-Boer, J. Lanfermeijer, H. Hoelen, L. Ijgosse, A.I. Costa, R.D. Gorham, R.J. Lebbink, E.J.H.J. Wiertz
The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins
published pages: 55-64, ISSN: 0161-5890, DOI: 10.1016/j.molimm.2018.05.025
Molecular Immunology 101 2019-07-08
2018 Patrique Praest, A. Manuel Liaci, Friedrich Förster, Emmanuel J.H.J. Wiertz
New insights into the structure of the MHC class I peptide-loading complex and mechanisms of TAP inhibition by viral immune evasion proteins
published pages: , ISSN: 0161-5890, DOI: 10.1016/j.molimm.2018.03.020
Molecular Immunology 2019-07-08
2017 Benson Ogunjimi, Shen-Ying Zhang, Katrine B. Sørensen, Kristian A. Skipper, Madalina Carter-Timofte, Gaspard Kerner, Stefanie Luecke, Thaneas Prabakaran, Yujia Cai, Josephina Meester, Esther Bartholomeus, Nikhita Ajit Bolar, Geert Vandeweyer, Charlotte Claes, Yasmine Sillis, Lazaro Lorenzo, Raffaele A. Fiorenza, Soraya Boucherit, Charlotte Dielman, Steven Heynderickx, George Elias, Andrea Kurotov
Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections
published pages: 3543-3556, ISSN: 0021-9738, DOI: 10.1172/JCI92280
Journal of Clinical Investigation 127/9 2019-07-08

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The information about "EDGE" are provided by the European Opendata Portal: CORDIS opendata.

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