Explore the words cloud of the EDGE project. It provides you a very rough idea of what is the project "EDGE" about.
The following table provides information about the project.
|Coordinator Country||Denmark [DK]|
|Total cost||3˙961˙943 €|
|EC max contribution||3˙961˙943 € (100%)|
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
|Duration (year-month-day)||from 2016-05-01 to 2020-04-30|
Take a look of project's partnership.
|1||AARHUS UNIVERSITET||DK (AARHUS C)||coordinator||580˙163.00|
|2||AARHUS UNIVERSITETSHOSPITAL||DK (AARHUS)||participant||580˙163.00|
|3||UNIVERSITA DEGLI STUDI DI TORINO||IT (TORINO)||participant||516˙122.00|
|4||UNIVERSITAIR MEDISCH CENTRUM UTRECHT||NL (UTRECHT)||participant||510˙748.00|
|5||HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH||DE (BRAUNSCHWEIG)||participant||498˙432.00|
|6||MEDIZINISCHE HOCHSCHULE HANNOVER||DE (HANNOVER)||participant||498˙432.00|
|7||THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD||UK (OXFORD)||participant||273˙287.00|
|8||JANSSEN VACCINES & PREVENTION BV||NL (LEIDEN)||participant||255˙374.00|
|9||MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV||DE (MUENCHEN)||participant||249˙216.00|
Herpesviruses are widely spread, and cause life-long infections. Most individuals carry multiple herpesviruses, which can cause severe diseases, especially in children, immunocompromised individuals, and elderly. There are currently no safe vaccines against herpesvirus infections and current treatments are not satisfactory. With new insights into the molecular basis for diseases caused by immunodeficiency, and with the increasing numbers of elderly in Europe, there is now an unmet demand for improved treatments of herpesvirus infections. Combined with the progress in basic herpesvirus research, this calls for education of a new generation of scientists with strong research skills, advanced insights into disease mechanisms, and understanding of how industry brings innovative research into the market. In this application we propose an interactive education program for early stage researchers (ESR) in leading European laboratories, hospitals, and biotech companies. The focus will be on the virology and immunology of herpesvirus infections in the context of basic research as well as application of research-acquired knowledge. Our program will prepare the ESRs to manage goal-oriented interactions between academia, the clinics, and the biotech industry. The ESRs will acquire broad theoretical and methodological expertises involving several sectors to obtain the skills required for overcoming the cultural gaps From Bench to Bedside and From Discovery to Innovation. This can only be achieved through a network-based approach. We propose to develop a platform to educate the next generation of scientists to solve the outstanding problems in prevention and treatment of herpesvirus infections. The ESRs will be ideally trained to translate cutting-edge discoveries to novel products and to innovative treatment serving the European people, and hence to improve handling of present and emerging health challenges, as well as to foster the European biopharmaceutical industry sector.
|Recruitment ESRs||Documents, reports||2019-05-31 11:52:24|
|Characterization of SLE phenotypes in mice â€“ and impact on CMV infection||Documents, reports||2019-05-31 12:00:46|
|Draft Periodic Report||Documents, reports||2019-05-31 12:00:52|
|Recruitment Manager||Documents, reports||2019-05-31 12:00:47|
|Mid-term review meeting||Documents, reports||2019-05-31 12:00:46|
|Patent and publications in int. journals starting||Documents, reports||2019-05-31 12:00:48|
|Communication of subject to high school students||Documents, reports||2019-05-31 12:00:49|
Take a look to the deliverables list in detail: detailed list of EDGE deliverables.
|year||authors and title||journal||last update|
Jonny Hertzog, Antonio Gregorio Dias Junior, Rachel E. Rigby, Claire L. Donald, Alice Mayer, Erdinc Sezgin, Chaojun Song, Boquan Jin, Philip Hublitz, Christian Eggeling, Alain Kohl, Jan Rehwinkel
Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling
published pages: , ISSN: 0014-2980, DOI: 10.1002/eji.201847483
|European Journal of Immunology||2019-07-08|
P. Praest, R.D. Luteijn, I.G.J. Brak-Boer, J. Lanfermeijer, H. Hoelen, L. Ijgosse, A.I. Costa, R.D. Gorham, R.J. Lebbink, E.J.H.J. Wiertz
The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins
published pages: 55-64, ISSN: 0161-5890, DOI: 10.1016/j.molimm.2018.05.025
|Molecular Immunology 101||2019-07-08|
Patrique Praest, A. Manuel Liaci, Friedrich FÃ¶rster, Emmanuel J.H.J. Wiertz
New insights into the structure of the MHC class I peptide-loading complex and mechanisms of TAP inhibition by viral immune evasion proteins
published pages: , ISSN: 0161-5890, DOI: 10.1016/j.molimm.2018.03.020
Benson Ogunjimi, Shen-Ying Zhang, Katrine B. SÃ¸rensen, Kristian A. Skipper, Madalina Carter-Timofte, Gaspard Kerner, Stefanie Luecke, Thaneas Prabakaran, Yujia Cai, Josephina Meester, Esther Bartholomeus, Nikhita Ajit Bolar, Geert Vandeweyer, Charlotte Claes, Yasmine Sillis, Lazaro Lorenzo, Raffaele A. Fiorenza, Soraya Boucherit, Charlotte Dielman, Steven Heynderickx, George Elias, Andrea Kurotov
Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections
published pages: 3543-3556, ISSN: 0021-9738, DOI: 10.1172/JCI92280
|Journal of Clinical Investigation 127/9||2019-07-08|
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