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FunCapSys SIGNED

Functional Systems of Capsules

Total Cost €

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EC-Contrib. €

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Partnership

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Project "FunCapSys" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙478˙236 €
 EC max contribution 2˙478˙236 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 2˙478˙236.00

Map

 Project objective

The simplest living organism is composed of myriad chemical subsystems, each consisting of structurally complex biomolecules that interact in many ways; the properties of life emerge from these dense connections. Understanding how these interactions take place will help elucidate the foundations of biology, as well as enabling the design and creation of new chemical networks with targeted functions. Deciphering and designing chemical systems requires new tools to be developed, however. In this research programme, we will develop new means for engineering functional chemical systems based upon the use of guest-binding capsules. These hosts will respond to many different signals in predictable ways. Their responses will enable their guests to be transformed in new ways or pumped between phases using light. Chemical signals will enable hosts to be transformed reversibly or irreversibly, changing their guest binding properties so as to favour some guests and disfavour others, and catalysts will be released or taken up, accelerating or impeding catalysed transformations. Ultimately we will design systems where signal transduction occurs in complex cycles and feedback loops, allowing complex behaviour to emerge from abiological systems.

 Publications

year authors and title journal last update
List of publications.
2019 Dawei Zhang, Tanya K. Ronson, Songül Güryel, John D. Thoburn, David J. Wales, Jonathan R. Nitschke
Temperature Controls Guest Uptake and Release from Zn 4 L 4 Tetrahedra
published pages: 14534-14538, ISSN: 0002-7863, DOI: 10.1021/jacs.9b07307
Journal of the American Chemical Society 141/37 2020-01-30
2019 Dawei Zhang, Tanya K. Ronson, Roy Lavendomme, Jonathan R. Nitschke
Selective Separation of Polyaromatic Hydrocarbons by Phase Transfer of Coordination Cages
published pages: 18949-18953, ISSN: 0002-7863, DOI: 10.1021/jacs.9b10741
Journal of the American Chemical Society 141/48 2020-01-30
2020 Zhenpin Lu, Tanya K. Ronson, Jonathan R. Nitschke
Reversible reduction drives anion ejection and C 60 binding within an FeII4L 6 cage
published pages: , ISSN: 2041-6520, DOI: 10.1039/c9sc05728e
Chemical Science 2020-01-30
2019 Masahiro Yamashina, Yuya Tanaka, Roy Lavendomme, Tanya K. Ronson, Michael Pittelkow, Jonathan R. Nitschke
An antiaromatic-walled nanospace
published pages: 511-515, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1661-x
Nature 574/7779 2020-01-30
2019 Charlie T. McTernan, Tanya K. Ronson, Jonathan R. Nitschke
Post-assembly Modification of Phosphine Cages Controls Host–Guest Behavior
published pages: 6837-6842, ISSN: 0002-7863, DOI: 10.1021/jacs.9b02604
Journal of the American Chemical Society 141/17 2020-01-22
2019 John P. Carpenter, Charlie T. McTernan, Tanya K. Ronson, Jonathan R. Nitschke
Anion Pairs Template a Trigonal Prism with Disilver Vertices
published pages: 11409-11413, ISSN: 0002-7863, DOI: 10.1021/jacs.9b05432
Journal of the American Chemical Society 141/29 2020-01-22
2018 Anna J. McConnell, Cally J. E. Haynes, Angela B. Grommet, Catherine M. Aitchison, Julia Guilleme, Sigitas Mikutis, Jonathan R. Nitschke
Orthogonal Stimuli Trigger Self-Assembly and Phase Transfer of Fe II 4 L 4 Cages and Cargoes
published pages: 16952-16956, ISSN: 0002-7863, DOI: 10.1021/jacs.8b11324
Journal of the American Chemical Society 140/49 2020-01-22
2018 Felix J. Rizzuto, Patrick Pröhm, Alex J. Plajer, Jake L. Greenfield, Jonathan R. Nitschke
Hydrogen-Bond-Assisted Symmetry Breaking in a Network of Chiral Metal–Organic Assemblies
published pages: 1707-1715, ISSN: 0002-7863, DOI: 10.1021/jacs.8b12323
Journal of the American Chemical Society 141/4 2020-01-22
2019 Roy Lavendomme, Tanya K. Ronson, Jonathan R. Nitschke
Metal and Organic Templates Together Control the Size of Covalent Macrocycles and Cages
published pages: 12147-12158, ISSN: 0002-7863, DOI: 10.1021/jacs.9b06182
Journal of the American Chemical Society 141/30 2020-01-22
2019 Anneli Kruve, Kenji Caprice, Roy Lavendomme, Jan M. Wollschläger, Stefan Schoder, Hendrik V. Schröder, Jonathan R. Nitschke, Fabien B. L. Cougnon, Christoph A. Schalley
Ion-Mobility Mass Spectrometry for the Rapid Determination of the Topology of Interlocked and Knotted Molecules
published pages: 11324-11328, ISSN: 1433-7851, DOI: 10.1002/anie.201904541
Angewandte Chemie International Edition 58/33 2020-01-22
2019 Felix J. Rizzuto, John P. Carpenter, Jonathan R. Nitschke
Multisite Binding of Drugs and Natural Products in an Entropically Favorable, Heteroleptic Receptor
published pages: 9087-9095, ISSN: 0002-7863, DOI: 10.1021/jacs.9b03776
Journal of the American Chemical Society 141/22 2020-01-22
2018 Angela B. Grommet, Jack B. Hoffman, Edmundo G. Percástegui, Jesús Mosquera, Duncan J. Howe, Jeanne L. Bolliger, Jonathan R. Nitschke
Anion Exchange Drives Reversible Phase Transfer of Coordination Cages and Their Cargoes
published pages: 14770-14776, ISSN: 0002-7863, DOI: 10.1021/jacs.8b07900
Journal of the American Chemical Society 140/44 2020-01-22
2019 Alex J. Plajer, Edmundo G. Percástegui, Marco Santella, Felix J. Rizzuto, Quan Gan, Bo W. Laursen, Jonathan R. Nitschke
Fluorometric Recognition of Nucleotides within a Water-Soluble Tetrahedral Capsule
published pages: 4200-4204, ISSN: 1433-7851, DOI: 10.1002/anie.201814149
Angewandte Chemie International Edition 58/13 2020-01-22
2019 Nozomi Mihara, Tanya K. Ronson, Jonathan R. Nitschke
Different Modes of Anion Response Cause Circulatory Phase Transfer of a Coordination Cage with Controlled Directionality
published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201906644
Angewandte Chemie International Edition 2020-01-22
2019 Felix J. Rizzuto, Larissa K. S. von Krbek, Jonathan R. Nitschke
Strategies for binding multiple guests in metal–organic cages
published pages: 204-222, ISSN: 2397-3358, DOI: 10.1038/s41570-019-0085-3
Nature Reviews Chemistry 3/4 2020-01-22
2019 Dawei Zhang, Tanya K. Ronson, Jake L. Greenfield, Thierry Brotin, Patrick Berthault, Estelle Léonce, Jun-Long Zhu, Lin Xu, Jonathan R. Nitschke
Enantiopure [Cs + /Xe⊂Cryptophane]⊂Fe II 4 L 4 Hierarchical Superstructures
published pages: , ISSN: 0002-7863, DOI: 10.1021/jacs.9b02866
Journal of the American Chemical Society 2020-01-22
2019 Zhenpin Lu, Roy Lavendomme, Olaf Burghaus, Jonathan R. Nitschke
A Zn 4 L 6 Capsule with Enhanced Catalytic C−C Bond Formation Activity upon C 60 Binding
published pages: 9073-9077, ISSN: 1433-7851, DOI: 10.1002/anie.201903286
Angewandte Chemie International Edition 58/27 2020-01-22
2019 Edmundo G. Percástegui, Jesús Mosquera, Tanya K. Ronson, Alex J. Plajer, Marion Kieffer, Jonathan R. Nitschke
Waterproof architectures through subcomponent self-assembly
published pages: 2006-2018, ISSN: 2041-6520, DOI: 10.1039/c8sc05085f
Chemical Science 10/7 2020-01-22
2018 Dawei Zhang, Tanya K. Ronson, Jonathan R. Nitschke
Functional Capsules via Subcomponent Self-Assembly
published pages: , ISSN: 0001-4842, DOI: 10.1021/acs.accounts.8b00303
Accounts of Chemical Research 2020-01-22
2018 Felix J. Rizzuto, William J. Ramsay, Jonathan R. Nitschke
Otherwise unstable structures self-assemble in the cavities of cuboctahedral coordination cages
published pages: , ISSN: 0002-7863, DOI: 10.1021/jacs.8b07494
Journal of the American Chemical Society 2020-01-22
2018 Jake L. Greenfield, Emrys W. Evans, Daniele Di Nuzzo, Marco Di Antonio, Richard H. Friend, Jonathan R. Nitschke
Unraveling Mechanisms of Chiral Induction in Double-Helical Metallopolymers
published pages: 10344–10353, ISSN: 0002-7863, DOI: 10.1021/jacs.8b06195
Journal of the American Chemical Society 140(32) 2020-01-22
2017 Anna J. McConnell, Catherine M. Aitchison, Angela B. Grommet, Jonathan R. Nitschke
Subcomponent Exchange Transforms an Fe II 4 L 4 Cage from High- to Low-Spin, Switching Guest Release in a Two-Cage System
published pages: 6294-6297, ISSN: 0002-7863, DOI: 10.1021/jacs.7b01478
Journal of the American Chemical Society 139/18 2020-01-22
2018 Jonathan Nitschke, Christoph A. Schalley, Ben S. Pilgrim, Derrick A. Roberts, Larissa K. S. von Krbek
Multivalent Crown-ether Receptors Enable Allosteric Regulation of Anion Exchange in an Fe₄L₆ Tetrahedron
published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201808534
Angewandte Chemie International Edition 2020-01-22
2017 Edmundo G. Percástegui, Jesús Mosquera, Jonathan R. Nitschke
Anion Exchange Renders Hydrophobic Capsules and Cargoes Water-Soluble
published pages: 9136-9140, ISSN: 1433-7851, DOI: 10.1002/anie.201705093
Angewandte Chemie International Edition 56/31 2020-01-22
2018 Derrick A. Roberts, Ben S. Pilgrim, Jonathan R. Nitschke
Covalent post-assembly modification in metallosupramolecular chemistry
published pages: 626-644, ISSN: 0306-0012, DOI: 10.1039/c6cs00907g
Chemical Society Reviews 47/2 2020-01-22
2018 Evan N. Keyzer, Alexandru Sava, Tanya K. Ronson, Jonathan R. Nitschke, Anna J. McConnell
Post-Assembly Reactivity of N -Aryl Iminoboronates: Reversible Radical Coupling and Unusual B−N Dynamic Covalent Chemistry
published pages: 12000-12005, ISSN: 0947-6539, DOI: 10.1002/chem.201802790
Chemistry - A European Journal 24(46) 2020-01-22

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