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TRANSGENE SIGNED

Medical translation in the history of modern genomics

Total Cost €

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EC-Contrib. €

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Partnership

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Project "TRANSGENE" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.stis.ed.ac.uk/transgene
 Total cost 1˙498˙708 €
 EC max contribution 1˙498˙708 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 1˙498˙708.00

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 Project objective

The translation of basic biomedical research into clinical practice has become a central concern for science policy. Policies to foster translation are being applied to large amounts of genomic information available in open-access databases. This information is the result of concerted initiatives that, in the early 2000s, determined the full genetic sequence that characterises humans and other organisms. However, when the initiatives started the goal of determining the full sequence and making the resulting information available was not universally supported. My project will investigate how and why this objective of completing the sequence was adopted in preference to other models that prioritised the usability of the data.

Newly available archives suggest that the yeast, human and pig genome initiatives underwent crucial changes from the mid-1980s onwards. In their early years, the priority had been rapid translation of results into the improvement of human and animal health. Consequently, sequence determination was limited to small areas of the genome for which there was an existing medical interest. However, as the initiatives progressed the systematic sequencing of the full genome prevailed over those approaches. My project will follow the development of these sidelined models that sought to use the sequences as they were produced, in order to investigate their significance for current translational research policies.

I will develop a collaborative framework in which archival research will be combined with insights from social studies of science and innovation studies. By doing this, I seek to bridge the current fragmentation between history of science and other fields of science studies focused on present-day events. In my project, biomedical translation will be approached as a historical process that unfolds over time and can be investigated with a cross-disciplinary set of tools, to be commonly applied to historical, contemporary and prospective studies.

 Publications

year authors and title journal last update
List of publications.
2018 James W. E. Lowe
Stephen Hilgartner, Reordering Life: Knowledge and Control in the Genomics Revolution, Cambridge Massachusetts, The MIT Press, 2017, xiv + 343 pp., May 2017, $35.00/£27.95
published pages: , ISSN: 0391-9714, DOI: 10.1007/s40656-017-0171-0
History and Philosophy of the Life Sciences 40/1 2020-01-29
2018 James W.E. Lowe
Sequencing through thick and thin: Historiographical and philosophical implications
published pages: 10-27, ISSN: 1369-8486, DOI: 10.1016/j.shpsc.2018.10.007
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 72 2020-01-29
2019 Mark Wong, Rhodri Leng, Gil Viry, Rodrigo Liscovsky Barrera, Miguel Garcia-Sancho
Human, yeast and pig genomics: sequence submissions and first sequence descriptions in the literature (1980-2015), 1980-2015 [dataset]
published pages: , ISSN: , DOI: 10.7488/ds/2589
2020-01-29
2019 Miguel García-Sancho, Dmitriy Myelnikov
Between mice and sheep: Biotechnology, agricultural science and animal models in late-twentieth century Edinburgh
published pages: 24-33, ISSN: 1369-8486, DOI: 10.1016/j.shpsc.2019.01.002
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 75 2020-01-29
2018 James W.E. Lowe
Sequencing through thick and thin: Historiographical and philosophical implications
published pages: 10-27, ISSN: 1369-8486, DOI: 10.1016/j.shpsc.2018.10.007
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 72 2020-01-29
2019 Mark Wong, Rhodri Leng
On the design of linked datasets mapping networks of collaboration in the genomic sequencing of Saccharomyces cerevisiae, Homo sapiens, and Sus scrofa
published pages: 1200, ISSN: 2046-1402, DOI: 10.12688/f1000research.18656.1
F1000Research 8 2020-01-29

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The information about "TRANSGENE" are provided by the European Opendata Portal: CORDIS opendata.

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