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OBESOGENS SIGNED

Environmental chemicals as obesogens

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "OBESOGENS" data sheet

The following table provides information about the project.

Coordinator
Masarykova univerzita 

Organization address
address: Zerotinovo namesti 9
city: BRNO STRED
postcode: 60177
website: http://www.muni.cz

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Project website https://www.researchgate.net/project/Environmental-chemicals-as-obesogens
 Total cost 249˙490 €
 EC max contribution 249˙490 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2019-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    Masarykova univerzita CZ (BRNO STRED) coordinator 249˙490.00
2    UNIVERSITY OF FLORIDA US (GAINESVILLE) partner 0.00

Map

 Project objective

Obesity is a serious health risk that has reached epidemic proportions worldwide. Obesity is traditionally considered a as disorder of energy imbalance imposed on a background of genetic disposition. In addition to risk factors such as diet and genetics, chemicals in our environment have emerged as contributing factors associated with an increased risk for obesity (i.e. obesogens). Phthalate esters, a ubiquitous class of chemicals used as plasticizers in products such as toys and hospital supplies, are suspected of being obesogens. Despite studies demonstrating that phthalate urine levels are associated with increased risk to obesity in children, meta-analyses report that current data are insufficient for determining whether phthalates do in fact increase the prevalence of obesity. Moreover, data are sparse on how obesogens affect metabolism and the feeding axis and there are fundamental gaps in our understanding of the precise mechanisms by which environmental chemicals exacerbate this human disease. The central hypothesis of this proposal is that exposures to phthalates will exacerbate molecular responses in the hypothalamus and gut that are observed during a regime of over-feeding. Further, the modification of the gut microbiota may be a relevant consequence of obesogens. The zebrafish (ZF) is one of the most important models in environmental toxicology and developmental biology, and is rapidly becoming a major model for studies in human health and metabolic diseases. ZF will be used to determine mechanisms that are associated to diet and chemical induced obesity, novel regulatory pathways in the hypothalamus and gut will be identified; this is important as these two tissues communicate via the endocrine system and there is direct innervation of the gut by the central nervous system. To be in line with 3R principles, high throughput screen method using ZF embryo will be developed to test environmental chemicals for their “obesogenic” potential.

 Publications

year authors and title journal last update
List of publications.
2018 Ondrej Adamovsky, Amanda Buerger, Alexis M. Wormington, Naomi Ector, Robert J. Griffitt, Joseph H. Bisesi, Christopher J. Martyniuk
The gut microbiome and aquatic toxicology: An emerging concept for environmental health
published pages: just published, ISSN: 0730-7268, DOI: 10.1002/etc.4249
Environmental Toxicology and Chemistry just published 2019-09-27

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