Explore the words cloud of the TransGen RNA project. It provides you a very rough idea of what is the project "TransGen RNA" about.
The following table provides information about the project.
|Coordinator Country||Denmark [DK]|
|Total cost||1˙344˙497 €|
|EC max contribution||1˙344˙497 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-05-01 to 2021-04-30|
Take a look of project's partnership.
|1||SYDDANSK UNIVERSITET||DK (ODENSE M)||coordinator||930˙637.00|
|2||MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV||DE (Munich)||participant||413˙860.00|
Obesity and T2D affect large populations and cause a decline in life expectancy if untreated. The pandemic proportion of obesity and inaptitude of anti-obesity approaches reflect our limited understanding of its complex environmental and genetic etiology. Genome-wide association studies revealed that disease-associated risk variants are often situated in those 98% of the genome not encoding for proteins. This noncoding genomic space yet does not reflect ‘Junk DNA’ but gives rise to >10,000 noncoding RNAs like microRNAs and long, noncoding RNAs (lncRNAs) that implicated in control of glucose metabolism and energy homeostasis also by the applicant (Kornfeld et al. Nature 2013).
LncRNAs were paraphrased as 'Dark matter of the genome' due to their tissue-specific and dynamic expression that contrast their poorly understood role in gene regulation. In the 1st part of this proposal, we ask if lncRNAs regulate glucose metabolism and are involved in the obesity-associated dysregulation of insulin signaling in the liver, the major glucoregulatory organ in mammals. Using RNA-Seq and novel lncRNA prediction algorithms, we observed that obesity alters expression of 28 annotated and 15 hitherto unknown lncRNAs in two mouse models of obesity. To identify lncRNAs causally controlling glucose metabolism, we established a siRNA screening system that allows functional interrogation of >650 lncRNAs. These in vitro findings serve as entry for the generation of lncRNA knockout mice that are metabolically phenotyped. In the 2nd part, we hypothesize that germline ncRNAs could control the transgenerational consequences of paternal obesity as shown for lower organisms. This builds upon unpublished findings from our lab showing that obesity profoundly changes expression of germline ncRNAs. In-vitro fertilization and intergenerational breedings will trace the legacy of paternal obesity across generations and reveal ncRNAs involved in this ‘Lamarckian’ control of glucose metabolism.
|year||authors and title||journal||last update|
Marta Pradas-Juni, Nils R. Hansmeier, Jenny C. Link, Elena Schmidt, BjÃ¸rk Ditlev Larsen, Paul Klemm, Nicola Meola, Hande Topel, Rute Loureiro, Ines Dhaouadi, Christoph A. Kiefer, Robin Schwarzer, Sajjad Khani, Matteo Oliverio, Motoharu Awazawa, Peter Frommolt, Joerg Heeren, Ludger Scheja, Markus Heine, Christoph Dieterich, Hildegard BÃ¼ning, Ling Yang, Haiming Cao, Dario F. De Jesus, Rohit N. Kul
A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-020-14323-y
|Nature Communications 11/1||2020-02-06|
Motoharu Awazawa, Paula Gabel, Eva Tsaousidou, Hendrik Nolte, Marcus KrÃ¼ger, Joel Schmitz, P Justus Ackermann, Claus Brandt, Janine AltmÃ¼ller, Susanne Motameny, F Thomas Wunderlich, Jan-Wilhelm Kornfeld, Matthias BlÃ¼her, Jens C BrÃ¼ning
A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle
published pages: 1466-1473, ISSN: 1078-8956, DOI: 10.1038/nm.4420
|Nature Medicine 23/12||2019-07-08|
Elena Schmidt, Jan-Wilhelm Kornfeld
Decoding Lamarckâ€”transgenerational control of metabolism by noncoding RNAs
published pages: 959-969, ISSN: 0031-6768, DOI: 10.1007/s00424-016-1807-8
|PflÃ¼gers Archiv - European Journal of Physiology 468/6||2019-07-08|
Delphine Duteil, Milica Tosic, Franziska Lausecker, HaticeÂ Z. Nenseth, JudithÂ M. MÃ¼ller, Sylvia Urban, Dominica Willmann, Kerstin Petroll, Nadia Messaddeq, Laura Arrigoni, Thomas Manke, Jan-Wilhelm Kornfeld, JensÂ C. BrÃ¼ning, Vyacheslav Zagoriy, Michael Meret, JÃ¶rn Dengjel, Toufike Kanouni, Roland SchÃ¼le
Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue
published pages: 1008-1021, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.09.053
|Cell Reports 17/4||2019-07-08|
Elena Schmidt, Ines Dhaouadi, Isabella Gaziano, Matteo Oliverio, Paul Klemm, Motoharu Awazawa, Gerfried Mitterer, Eduardo Fernandez-Rebollo, Marta Pradas-Juni, Wolfgang Wagner, Philipp Hammerschmidt, Rute Loureiro, Christoph Kiefer, Nils R. Hansmeier, Sajjad Khani, Matteo Bergami, Markus Heine, Evgenia Ntini, Peter Frommolt, Peter Zentis, Ulf Andersson Ã˜rom, JÃ¶rg Heeren, Matthias BlÃ¼her, Martin Bilban, Jan-Wilhelm Kornfeld
LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05933-8
|Nature Communications 9/1||2019-05-10|
Nils R. Hansmeier, Pia J. M. Widdershooven, Sajjad Khani, Jan-Wilhelm Kornfeld
Rapid Generation of Long Noncoding RNA Knockout Mice Using CRISPR/Cas9 Technology
published pages: 12, ISSN: 2311-553X, DOI: 10.3390/ncrna5010012
|Non-Coding RNA 5/1||2019-03-12|
Paul Klemm, Peter Frommolt, Jan-Wilhelm Kornfeld
s Â·nr: a visual analytics framework for contextual analyses of private and public RNA-seq data
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-018-5396-0
|BMC Genomics 20/1||2019-03-12|
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