Explore the words cloud of the NIRV_HOST_INT project. It provides you a very rough idea of what is the project "NIRV_HOST_INT" about.
The following table provides information about the project.
UNIVERSITA DEGLI STUDI DI PAVIA
|Coordinator Country||Italy [IT]|
|Total cost||1˙686˙875 €|
|EC max contribution||1˙686˙875 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-05-01 to 2021-04-30|
Take a look of project's partnership.
|1||UNIVERSITA DEGLI STUDI DI PAVIA||IT (PAVIA)||coordinator||1˙466˙875.00|
|2||INSTITUT PASTEUR||FR (PARIS CEDEX 15)||participant||220˙000.00|
Recent discoveries clearly show that non-retroviral RNA viruses, despite not coding for reverse transcriptase and integrase, can transfer genetic material to their hosts, similarly to DNA viruses and retroviruses. The distribution of non-retroviral integrated RNA viruses (NIRVs) in host populations, mechanisms of NIRVs formation and effects on hosts are unclear. The main objective of this proposal is to uncover the complex biological interactions between non-retroviral RNA viruses and their hosts using the model system “Aedes albopictus and Flavivirus”. This system is ideal because Ae. albopictus is a known vector of non-retroviral RNA viruses, including several highly relevant for public health such as dengue viruses (Flaviviridae, Flavivirus) and NIRVs phylogenetically related to Flaviviruses have been identified in its genome. First, a population genomic approach will be used to interrogate the genome of Ae. albopictus from different geographic populations at their DNA and RNA levels. This approach will permit the systematic characterization of the distributions of NIRVs in natural host populations, the analyses of correlations between the presence of NIRVs and viral infections and the description of NIRVs genomic context, from which insights on mechanisms of NIRVs formation can be derived. Secondly, tissue-specificity of the NIRVs, their trans-generational stability and impact on mosquito biology will be analysed in a controlled laboratory environment. Somatic integrations could contribute to acquired immunity to their respective viruses or establishment of persistent viral infection. Germ-line integrations could have an evolutionary impact. If NIRVs affect Ae. albopictus vector competence or the genome of emerging viral populations, they could be manipulated for vector control purposes. Additionally, results on NIRV distribution in natural host populations and mechanisms of NIRVs formation will have implications in medicine because several non-retroviral RNA viruses are emerging as delivery systems for gene therapy applications.
|year||authors and title||journal||last update|
Francesca Scolari, Maurizio Casiraghi and Mariangela Bonizzoni
Aedes spp. and Their Microbiota: A Review
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2019.02036
|Frontiers in Microbiology||2020-03-11|
Michele Marconcini, Luis Hernandez, Giuseppe Iovino, Vincent HouÃ©, Federica Valerio,
Umberto Palatini, Elisa Pischedda, Jacob Crawford, Rebeca Carballar-Lejarazu, Lino Ometto, Federico Forneris, Anna-Bella Failloux, Mariangela Bonizzoni
Polymorphism analyses and protein modelling inform on functional specialization of Piwi clade genes in the arboviral vector Aedes albopictus
published pages: , ISSN: 0000-0000, DOI: 10.1101/677062
Vincent HouÃ©, Mariangela Bonizzoni, Anna-Bella Failloux
Endogenous non-retroviral elements in genomes of Aedes mosquitoes and vector competence
published pages: 542-555, ISSN: 2222-1751, DOI: 10.1080/22221751.2019.1599302
|Emerging Microbes & Infections 8/1||2020-03-11|
Elisa Pischedda, Francesca Scolari, Federica Valerio, Rebeca Carballar-LejarazÃº, Paolo Luigi Catapano, Robert M. Waterhouse, Mariangela Bonizzoni
Insights Into an Unexplored Component of the Mosquito Repeatome: Distribution and Variability of Viral Sequences Integrated Into the Genome of the Arboviral Vector Aedes albopictus
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.00093
|Frontiers in Genetics 10||2020-03-11|
Elisa Pischedda, Francesca Scolari, Federica Valerio, Rebeca CarballarLejarazÃº,Paolo Luigi Catapano
,RobertM.Waterhouse and Mariangela Bonizzoni
Evolutionary landscape of mosquito viral integrations
published pages: , ISSN: , DOI: 10.1101/385666
Carol D. Blair, Ken E. Olson, Mariangela Bonizzoni
The Widespread Occurrence and Potential Biological Roles of Endogenous Viral Elements in Insect Genomes
published pages: 13-30, ISSN: 1467-3037, DOI: 10.21775/cimb.034.013
|Current Issues in Molecular Biology||2020-03-11|
Ken E Olson, Mariangela Bonizzoni
Nonretroviral integrated RNA viruses in arthropod vectors: an occasional event or something more?
published pages: 45-53, ISSN: 2214-5745, DOI: 10.1016/j.cois.2017.05.010
|Current Opinion in Insect Science 22||2020-03-11|
Vincent HouÃ©, Gaelle Gabiane, Catherine Dauga, Marie Suez, Yoann Madec, Laurence Mousson, Michele Marconcini, Pei-Shi Yen, Xavier de Lamballerie, Mariangela Bonizzoni and Anna-Bella Failloux
Evolution and biological significance of flaviviral elements in the genome of the arboviral vector Aedes albopictus
published pages: , ISSN: 2222-1751, DOI: 10.1080/22221751.2019.1657785
|Emerging Microbes and Infections||2020-03-11|
Umberto Palatini, Pascal Miesen, Rebeca Carballar-Lejarazu, Lino Ometto, Ettore Rizzo, Zhijian Tu, Ronald P. van Rij, Mariangela Bonizzoni
Comparative genomics shows that viral integrations are abundant and express piRNAs in the arboviral vectors Aedes aegypti and Aedes albopictus
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-017-3903-3
|BMC Genomics 18/1||2020-03-11|
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