Opendata, web and dolomites


Population genomics of co-evolution between non-retroviral RNA viruses and their hosts

Total Cost €


EC-Contrib. €






 NIRV_HOST_INT project word cloud

Explore the words cloud of the NIRV_HOST_INT project. It provides you a very rough idea of what is the project "NIRV_HOST_INT" about.

retroviral    tissue    phylogenetically    biology    distributions    establishment    mosquito    genetic    persistent    population    systematic    interactions    therapy    germ    immunity    rna    respective    additionally    permit    retroviruses    populations    flavivirus    similarly    competence    genomic    medicine    generational    hosts    transcriptase    gene    purposes    evolutionary    dengue    health    natural    vector    mechanisms    genome    analysed    stability    public    flaviviridae    description    albopictus    uncover    levels    infection    laboratory    nirv    recent    ideal    reverse    specificity    acquired    integrations    dna    infections    environment    ae    discoveries    insights    host    aedes    despite    secondly    somatic    characterization    geographic    interrogate    coding    model    manipulated    nirvs    integrase    biological    flaviviruses    transfer    context    implications    viral    viruses    unclear    trans    correlations    first    line    material   

Project "NIRV_HOST_INT" data sheet

The following table provides information about the project.


Organization address
address: STRADA NUOVA 65
city: PAVIA
postcode: 27100

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 1˙686˙875 €
 EC max contribution 1˙686˙875 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2021-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PAVIA IT (PAVIA) coordinator 1˙466˙875.00
2    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 220˙000.00


 Project objective

Recent discoveries clearly show that non-retroviral RNA viruses, despite not coding for reverse transcriptase and integrase, can transfer genetic material to their hosts, similarly to DNA viruses and retroviruses. The distribution of non-retroviral integrated RNA viruses (NIRVs) in host populations, mechanisms of NIRVs formation and effects on hosts are unclear. The main objective of this proposal is to uncover the complex biological interactions between non-retroviral RNA viruses and their hosts using the model system “Aedes albopictus and Flavivirus”. This system is ideal because Ae. albopictus is a known vector of non-retroviral RNA viruses, including several highly relevant for public health such as dengue viruses (Flaviviridae, Flavivirus) and NIRVs phylogenetically related to Flaviviruses have been identified in its genome. First, a population genomic approach will be used to interrogate the genome of Ae. albopictus from different geographic populations at their DNA and RNA levels. This approach will permit the systematic characterization of the distributions of NIRVs in natural host populations, the analyses of correlations between the presence of NIRVs and viral infections and the description of NIRVs genomic context, from which insights on mechanisms of NIRVs formation can be derived. Secondly, tissue-specificity of the NIRVs, their trans-generational stability and impact on mosquito biology will be analysed in a controlled laboratory environment. Somatic integrations could contribute to acquired immunity to their respective viruses or establishment of persistent viral infection. Germ-line integrations could have an evolutionary impact. If NIRVs affect Ae. albopictus vector competence or the genome of emerging viral populations, they could be manipulated for vector control purposes. Additionally, results on NIRV distribution in natural host populations and mechanisms of NIRVs formation will have implications in medicine because several non-retroviral RNA viruses are emerging as delivery systems for gene therapy applications.


year authors and title journal last update
List of publications.
2019 Francesca Scolari, Maurizio Casiraghi and Mariangela Bonizzoni
Aedes spp. and Their Microbiota: A Review
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2019.02036
Frontiers in Microbiology 2020-03-11
2019 Michele Marconcini, Luis Hernandez, Giuseppe Iovino, Vincent Houé, Federica Valerio, Umberto Palatini, Elisa Pischedda, Jacob Crawford, Rebeca Carballar-Lejarazu, Lino Ometto, Federico Forneris, Anna-Bella Failloux, Mariangela Bonizzoni
Polymorphism analyses and protein modelling inform on functional specialization of Piwi clade genes in the arboviral vector Aedes albopictus
published pages: , ISSN: 0000-0000, DOI: 10.1101/677062
BioRxiv 2020-03-11
2019 Vincent Houé, Mariangela Bonizzoni, Anna-Bella Failloux
Endogenous non-retroviral elements in genomes of Aedes mosquitoes and vector competence
published pages: 542-555, ISSN: 2222-1751, DOI: 10.1080/22221751.2019.1599302
Emerging Microbes & Infections 8/1 2020-03-11
2019 Elisa Pischedda, Francesca Scolari, Federica Valerio, Rebeca Carballar-Lejarazú, Paolo Luigi Catapano, Robert M. Waterhouse, Mariangela Bonizzoni
Insights Into an Unexplored Component of the Mosquito Repeatome: Distribution and Variability of Viral Sequences Integrated Into the Genome of the Arboviral Vector Aedes albopictus
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.00093
Frontiers in Genetics 10 2020-03-11
2018 Elisa Pischedda, Francesca Scolari, Federica Valerio, Rebeca CarballarLejarazú,Paolo Luigi Catapano ,RobertM.Waterhouse and Mariangela Bonizzoni
Evolutionary landscape of mosquito viral integrations
published pages: , ISSN: , DOI: 10.1101/385666
2019 Carol D. Blair, Ken E. Olson, Mariangela Bonizzoni
The Widespread Occurrence and Potential Biological Roles of Endogenous Viral Elements in Insect Genomes
published pages: 13-30, ISSN: 1467-3037, DOI: 10.21775/cimb.034.013
Current Issues in Molecular Biology 2020-03-11
2017 Ken E Olson, Mariangela Bonizzoni
Nonretroviral integrated RNA viruses in arthropod vectors: an occasional event or something more?
published pages: 45-53, ISSN: 2214-5745, DOI: 10.1016/j.cois.2017.05.010
Current Opinion in Insect Science 22 2020-03-11
2019 Vincent Houé, Gaelle Gabiane, Catherine Dauga, Marie Suez, Yoann Madec, Laurence Mousson, Michele Marconcini, Pei-Shi Yen, Xavier de Lamballerie, Mariangela Bonizzoni and Anna-Bella Failloux
Evolution and biological significance of flaviviral elements in the genome of the arboviral vector Aedes albopictus
published pages: , ISSN: 2222-1751, DOI: 10.1080/22221751.2019.1657785
Emerging Microbes and Infections 2020-03-11
2017 Umberto Palatini, Pascal Miesen, Rebeca Carballar-Lejarazu, Lino Ometto, Ettore Rizzo, Zhijian Tu, Ronald P. van Rij, Mariangela Bonizzoni
Comparative genomics shows that viral integrations are abundant and express piRNAs in the arboviral vectors Aedes aegypti and Aedes albopictus
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-017-3903-3
BMC Genomics 18/1 2020-03-11

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NIRV_HOST_INT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NIRV_HOST_INT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

SUExp (2018)

Strategic Uncertainty: An Experimental Investigation

Read More  


Dissecting the chromatin response to DNA damage in silenced heterochromatin regions

Read More  


The Enemy of the Good: Towards a Theory of Moral Progress

Read More