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CHIKV-FBDD SIGNED

Structural investigation into functionality of Chikungunya virus nsP2 in replication complex and screening of small molecules for its inhibition

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Outcomes and results

 CHIKV-FBDD project word cloud

Explore the words cloud of the CHIKV-FBDD project. It provides you a very rough idea of what is the project "CHIKV-FBDD" about.

ground    form    screening    identification    genome    create    elucidate    techniques    central    organization    persisting    togaviridae    assays    biophysical    drug    elaboration    positive    defence    small    molecules    pathogen    crystallographic    druggability    pockets    first    newly    leads    chemical    eliminating    chikv    characterizing    fluorescence    clear    viral    explored    fever    released    antiviral    inhibitory    counteracting    protein    binding    single    interfere    platforms    existent    people    vitro    sense    attractive    exhibiting    surface    structural    recombinant    inhibitors    reveal    causes    variety    alphavirus    proteolytic    intense    cellular    virus    chronic    contacts    proteins    whereas    chikungunya    joint    libraries    discovered    spatial    largely    interaction    precursor    family    sensitive    plays    arthritis    nsp2    limited    ns    pain    polyprotein    fragments    replication    cycle    revealed    functional    medically    compounds    biology    rna    stranded    initially    multifunctional    regarding    mechanisms    millions    world    enzymatic    infection   

Project "CHIKV-FBDD" data sheet

The following table provides information about the project.

Coordinator		 THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-06-07   to  2018-06-06

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 195˙454.00

Map

 Project objective

Chikungunya virus (CHIKV) is a medically important pathogen that affected millions of people around the world. CHIKV infection causes high fever, intense joint pain and often leads to chronic virus-induced arthritis, thus there is a clear necessity to develop antiviral compounds capable of eliminating persisting virus. CHIKV is an alphavirus from Togaviridae family with single-stranded positive-sense RNA genome, which replication is carried out by a complex of four viral non-structural (ns) proteins, initially produced in a form of ns-polyprotein precursor and released by proteolytic processing. Because multifunctional nsP2 plays a central role in a replication cycle of CHIKV by exhibiting various enzymatic activities and counteracting cellular defence mechanisms, it represents the most attractive target for drug design and screening. Currently, the structural information regarding CHIKV ns-proteins is limited, whereas the platforms for in vitro testing the potential inhibitors are largely non-existent. Therefore the first aims of this project will be to apply structural biology approaches to elucidate spatial organization of nsP2 and to reveal its contacts with other ns-proteins in the replication complex. The druggability of nsP2 will be then explored by screening recombinant proteins against libraries of chemical fragments and characterizing binding of small molecules using sensitive biophysical techniques and crystallographic analysis. The potential of selected compounds to interfere with enzymatic or interaction properties of nsP2 will be revealed using variety of fluorescence-based assays developed in this project. The newly discovered knowledge about structural features of CHIKV nsP2, identification of novel protein surface pockets and binding molecules, and the development of functional assays for the analysis of their inhibitory potential are expected to create the ground for future elaboration of novel specific inhibitors of CHIKV.

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The information about "CHIKV-FBDD" are provided by the European Opendata Portal: CORDIS opendata.

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