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incerta2cortex SIGNED

Neocortical long-range inhibition for learning and memory

Total Cost €

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EC-Contrib. €

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Partnership

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 incerta2cortex project word cloud

Explore the words cloud of the incerta2cortex project. It provides you a very rough idea of what is the project "incerta2cortex" about.

insights    mice    optogenetic    techniques    projections    scientific    neocortical    functional    human    conditioning    ideal    viral    acx    sends    incerta    auditory    subthalamic    interactions    implications    tracing    diverse    central    slice    local    stepping    identity    markers    circuit    completion    combination    rigorous    function    collective    associative    neuronal    independence    dissect    critical    excitatory    tolerable    recording    fact    conjunction    encoding    plastic    edge    lab    unknown    hard    learning    fear    outline    nucleus    artificial    degree    software    found    recordings    receives    memory    extreme    strategy    treatment    imaging    multidisciplinary    training    interconnectivity    zi    brain    reaching    contributes    inputs    intelligence    successful    layer    l1    investigation    reveal    stone    remember    disorders    individual    lri    academic    cutting    underlie    mechanisms    zona    plasticity    transition    vivo    genetic    manipulations    cortex    efficient    inhibitory    host    mechanistic    isolation    functions    fundamental    precisely    interact    completely    life    circuits    fascinating   

Project "incerta2cortex" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 174˙806 €
 EC max contribution 174˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 174˙806.00

Map

 Project objective

The ability to learn from experience and remember one’s past is one of the most fundamental and fascinating functions of the brain that is also a central element of individual and collective human identity. A mechanistic understanding of memory has implications reaching from treatment of memory disorders to artificial intelligence and efficient hard- and software design. While by now we have a tolerable understanding of how local circuits implement the plastic changes that underlie learning and memory, brain areas do not function in isolation. In fact, it is precisely the extreme degree of neuronal interconnectivity that makes brain research such a fascinating challenge. Therefore, the critical next step in learning and memory research is to dissect how long-range interactions between different brain areas contribute to, and interact with, local plasticity to enable functional circuit plasticity. Neocortical layer 1 (L1) receives diverse long-range excitatory inputs, many of which are known to be important for learning. However, my host lab has recently found that the zona incerta (ZI) – a subthalamic nucleus – sends long-range inhibitory (LRI) projections to L1 of the auditory cortex (ACx). Whether and how LRI contributes to memory encoding mechanisms in neocortical circuits is completely unknown. Here I outline a strategy to dissect how LRI projections from the ZI to L1 ACx contribute to learning and memory, using a combination of cutting-edge in vivo imaging and recording techniques in conjunction with associative fear conditioning, optogenetic manipulations, viral tracing, genetic markers and slice recordings in mice. This multidisciplinary investigation will reveal important insights into how long-range interactions between brain areas contribute to learning and memory. Moreover, successful completion of this project, and rigorous training in other aspects of academic life, will provide the ideal stepping stone for my transition to scientific independence.

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The information about "INCERTA2CORTEX" are provided by the European Opendata Portal: CORDIS opendata.

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