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incerta2cortex SIGNED

Neocortical long-range inhibition for learning and memory

Total Cost €

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EC-Contrib. €

0

Partnership

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 incerta2cortex project word cloud

Explore the words cloud of the incerta2cortex project. It provides you a very rough idea of what is the project "incerta2cortex" about.

collective    plastic    acx    ideal    associative    fascinating    reaching    subthalamic    completely    human    layer    fact    investigation    interconnectivity    reveal    extreme    brain    transition    disorders    functional    viral    sends    circuit    cortex    genetic    contributes    function    mechanisms    diverse    precisely    identity    recording    optogenetic    manipulations    interactions    efficient    encoding    completion    excitatory    receives    critical    vivo    software    inhibitory    techniques    remember    stepping    stone    zi    lri    mice    insights    incerta    implications    individual    memory    interact    neuronal    fundamental    inputs    recordings    imaging    scientific    conditioning    independence    mechanistic    l1    intelligence    nucleus    degree    projections    life    zona    tracing    functions    neocortical    fear    plasticity    dissect    found    markers    academic    edge    circuits    central    outline    learning    underlie    hard    multidisciplinary    cutting    unknown    treatment    conjunction    auditory    combination    host    tolerable    slice    successful    strategy    local    training    isolation    rigorous    lab    artificial   

Project "incerta2cortex" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 174˙806 €
 EC max contribution 174˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 174˙806.00

Map

 Project objective

The ability to learn from experience and remember one’s past is one of the most fundamental and fascinating functions of the brain that is also a central element of individual and collective human identity. A mechanistic understanding of memory has implications reaching from treatment of memory disorders to artificial intelligence and efficient hard- and software design. While by now we have a tolerable understanding of how local circuits implement the plastic changes that underlie learning and memory, brain areas do not function in isolation. In fact, it is precisely the extreme degree of neuronal interconnectivity that makes brain research such a fascinating challenge. Therefore, the critical next step in learning and memory research is to dissect how long-range interactions between different brain areas contribute to, and interact with, local plasticity to enable functional circuit plasticity. Neocortical layer 1 (L1) receives diverse long-range excitatory inputs, many of which are known to be important for learning. However, my host lab has recently found that the zona incerta (ZI) – a subthalamic nucleus – sends long-range inhibitory (LRI) projections to L1 of the auditory cortex (ACx). Whether and how LRI contributes to memory encoding mechanisms in neocortical circuits is completely unknown. Here I outline a strategy to dissect how LRI projections from the ZI to L1 ACx contribute to learning and memory, using a combination of cutting-edge in vivo imaging and recording techniques in conjunction with associative fear conditioning, optogenetic manipulations, viral tracing, genetic markers and slice recordings in mice. This multidisciplinary investigation will reveal important insights into how long-range interactions between brain areas contribute to learning and memory. Moreover, successful completion of this project, and rigorous training in other aspects of academic life, will provide the ideal stepping stone for my transition to scientific independence.

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The information about "INCERTA2CORTEX" are provided by the European Opendata Portal: CORDIS opendata.

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